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PDB: 50 件
1ZW9
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Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine
分子名称: 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE, HSP82
著者Immormino, R.M, Gewirth, D.T, Chiosis, G.
登録日2005-06-03
公開日2006-06-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published
3OO0
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BU of 3oo0 by Molmil
Structure of apo CheY A113P
分子名称: AMMONIUM ION, Chemotaxis protein CheY, GLYCEROL, ...
著者Pazy, Y, Collins, E.J, Guanga, G.P, Miller, P.J, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
登録日2010-08-30
公開日2011-08-31
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Exploring the effect of an allosteric site on conformational coupling in CheY
To be Published
4HNW
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BU of 4hnw by Molmil
The NatA Acetyltransferase Complex Bound To Inositol Hexakisphosphate
分子名称: INOSITOL HEXAKISPHOSPHATE, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1, ...
著者Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D.
登録日2012-10-21
公開日2014-03-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
4HNY
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BU of 4hny by Molmil
Apo N-terminal acetyltransferase complex A
分子名称: GLYCEROL, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1, ...
著者Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D.
登録日2012-10-21
公開日2014-03-26
実験手法X-RAY DIFFRACTION (2.249 Å)
主引用文献The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
4HNX
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BU of 4hnx by Molmil
The NatA Acetyltransferase Complex Bound To ppGpp
分子名称: GUANOSINE-5',3'-TETRAPHOSPHATE, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-terminal acetyltransferase A complex subunit NAT1
著者Neubauer, J.L, Immormino, R.M, Dollins, D.E, Endo-Streeter, S.T, Pemble IV, C.W, York, J.D.
登録日2012-10-21
公開日2014-03-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.339 Å)
主引用文献The Protein Complex NatA Binds Inositol Hexakisphosphate and Exhibits Conformational Flexibility
To be Published
6D1X
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BU of 6d1x by Molmil
N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
分子名称: Endoplasmin, N-PROPYL CARBOXYAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
著者Gewirth, D.T, Immormino, R.M.
登録日2018-04-12
公開日2018-05-02
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J.Biol.Chem., 294, 2019
2O1T
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BU of 2o1t by Molmil
Structure of Middle plus C-terminal domains (M+C) of GRP94
分子名称: Endoplasmin
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1U
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BU of 2o1u by Molmil
Structure of full length GRP94 with AMP-PNP bound
分子名称: Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1V
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BU of 2o1v by Molmil
Structure of full length GRP94 with ADP bound
分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1W
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BU of 2o1w by Molmil
Structure of N-terminal plus middle domains (N+M) of GRP94
分子名称: Endoplasmin
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
1U0Z
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BU of 1u0z by Molmil
N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
分子名称: Endoplasmin, PENTAETHYLENE GLYCOL, RADICICOL, ...
著者Gewirth, D.T, Immormino, R.M.
登録日2004-07-14
公開日2005-07-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
TO BE PUBLISHED
1TBW
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BU of 1tbw by Molmil
Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation
分子名称: ADENOSINE MONOPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
著者Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
登録日2004-05-20
公開日2004-08-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC0
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BU of 1tc0 by Molmil
Ligand Induced Conformational Shifts in the N-terminal Domain of GRP94, Open Conformation Complexed with the physiological partner ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
著者Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
登録日2004-05-20
公開日2004-08-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC6
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BU of 1tc6 by Molmil
Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation ADP-Complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
著者Gewirth, D.T, Immormino, R.M, Dollins, D.E, Shaffer, P.L, Walker, M.A, Soldano, K.L.
登録日2004-05-20
公開日2004-08-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
2EXL
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BU of 2exl by Molmil
GRP94 N-terminal Domain bound to geldanamycin
分子名称: Endoplasmin, GELDANAMYCIN, PENTAETHYLENE GLYCOL, ...
著者Reardon, P.N, Immormino, R.M, Gewirth, D.T.
登録日2005-11-08
公開日2006-10-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388, 2009
3RVP
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BU of 3rvp by Molmil
Structure of the CheY-BeF3 Complex with substitutions at 59 and 89: N59D and E89K
分子名称: BERYLLIUM TRIFLUORIDE ION, Chemotaxis protein CheY, GLYCEROL, ...
著者Starbird, C.A, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
登録日2011-05-06
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.404 Å)
主引用文献Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.
Biochemistry, 54, 2015
3RVL
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BU of 3rvl by Molmil
Structure of the CheY-BeF3 Complex with substitutions at 59 and 89: N59D and E89R
分子名称: BERYLLIUM TRIFLUORIDE ION, Chemotaxis protein CheY, GLYCEROL, ...
著者Starbird, C.A, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
登録日2011-05-06
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.
Biochemistry, 54, 2015
3RVJ
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BU of 3rvj by Molmil
Structure of the CheY-BeF3 Complex with substitutions at 59 and 89: N59D and E89Q
分子名称: BERYLLIUM TRIFLUORIDE ION, Chemotaxis protein CheY, GLYCEROL, ...
著者Starbird, C.A, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
登録日2011-05-06
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.
Biochemistry, 54, 2015
3RVM
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BU of 3rvm by Molmil
Structure of the CheY-Mn2+ Complex with substitutions at 59 and 89: N59D and E89R
分子名称: Chemotaxis protein CheY, MANGANESE (II) ION
著者Starbird, C.A, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
登録日2011-05-06
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.
Biochemistry, 54, 2015
3RVN
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BU of 3rvn by Molmil
Structure of the CheY-BeF3 Complex with substitutions at 59 and 89: N59D and E89Y
分子名称: BERYLLIUM TRIFLUORIDE ION, Chemotaxis protein CheY, GLYCEROL, ...
著者Starbird, C.A, Immormino, R.M, Silversmith, R.E, Bourret, R.B.
登録日2011-05-06
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.
Biochemistry, 54, 2015
1YT2
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BU of 1yt2 by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N APO CRYSTAL
分子名称: Endoplasmin, TETRAETHYLENE GLYCOL
著者Dollins, D.E, Immormino, R.M, Gewirth, D.T.
登録日2005-02-09
公開日2005-06-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YSZ
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BU of 1ysz by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
分子名称: Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, TETRAETHYLENE GLYCOL
著者Dollins, D.E, Immormino, R.M, Gewirth, D.T.
登録日2005-02-09
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT0
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BU of 1yt0 by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION, ...
著者Dollins, D.E, Immormino, R.M, Gewirth, D.T.
登録日2005-02-09
公開日2005-06-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT1
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BU of 1yt1 by Molmil
Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL
分子名称: Endoplasmin, PENTAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
著者Dollins, D.E, Immormino, R.M, Gewirth, D.T.
登録日2005-02-09
公開日2005-06-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
2AQ9
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BU of 2aq9 by Molmil
Structure of E. coli LpxA with a bound peptide that is competitive with acyl-ACP
分子名称: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, DIMETHYL SULFOXIDE, PHOSPHATE ION, ...
著者Williams, A.H, Immormino, R.M, Gewirth, D.T, Raetz, C.R.
登録日2005-08-17
公開日2006-06-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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