1LME
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![BU of 1lme by Molmil](/molmil-images/mine/1lme) | Crystal Structure of Peptide Deformylase from Thermotoga maritima | Descriptor: | peptide deformylase | Authors: | Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | Deposit date: | 2002-05-01 | Release date: | 2003-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase J.MOL.BIOL., 330, 2003
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1OO7
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![BU of 1oo7 by Molmil](/molmil-images/mine/1oo7) | DNA.RNA HYBRID DUPLEX CONTAINING A 5-PROPYNE DNA STRAND AND PURINE-RICH RNA STRAND, NMR, 4 STRUCTURES | Descriptor: | 5'-D(*GP*(5PC)P*(PDU)P*(PDU)P*(5PC)P*(PDU)P*(5PC)P*(PDU)P*(PDU)P*C)-3', 5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3' | Authors: | Gyi, J.I, Gao, D, Conn, G.L, Trent, J.O, Brown, T, Lane, A.N. | Deposit date: | 2003-03-03 | Release date: | 2003-11-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications Nucleic Acids Res., 31, 2003
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4QFJ
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![BU of 4qfj by Molmil](/molmil-images/mine/4qfj) | The crystal structure of rat angiogenin-heparin complex | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACETIC ACID, Angiogenin, ... | Authors: | Yeo, K.J, Hwang, E, Min, K.M, Hwang, K.Y, Jeon, Y.H, Chang, S.I, Cheong, H.K. | Deposit date: | 2014-05-21 | Release date: | 2014-08-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.196 Å) | Cite: | The crystal structure of rat angiogenin-heparin complex To be Published
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4BWL
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![BU of 4bwl by Molmil](/molmil-images/mine/4bwl) | Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid | Descriptor: | 2-(ACETYLAMINO)-2-DEOXY-D-MANNOSE, 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid, N-ACETYLNEURAMINATE LYASE, ... | Authors: | Campeotto, I, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A. | Deposit date: | 2013-07-03 | Release date: | 2014-02-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, Qm/Mm Simulation and Mutagenesis. Acs Chem.Biol., 9, 2014
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1OQR
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![BU of 1oqr by Molmil](/molmil-images/mine/1oqr) | Crystal structure of C73S mutant of putidaredoxin, a [2Fe-2S] ferredoxin from Pseudomonas putida, at 1.65A resolution | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, Putidaredoxin | Authors: | Sevrioukova, I.F, Garcia, C, Li, H, Bhaskar, B, Poulos, T.L. | Deposit date: | 2003-03-10 | Release date: | 2003-11-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida J.MOL.BIOL., 333, 2003
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2GGE
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![BU of 2gge by Molmil](/molmil-images/mine/2gge) | Crystal Structure of Mandelate Racemase/Muconate Lactonizing Enzyme from Bacillus Subtilis complexed with MG++ at 1.8 A | Descriptor: | CHLORIDE ION, MAGNESIUM ION, yitF | Authors: | Malashkevich, V.N, Sauder, J.M, Schwinn, K.D, Emtage, S, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Burley, S.K, Sali, A, Babbitt, P, Pieper, U, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-03-23 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal Structure of Mandelate Racemase/Muconate Lactonizing Enzyme from Bacillus Subtilis complexed with MG++ at 1.8 A To be Published
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5TT7
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![BU of 5tt7 by Molmil](/molmil-images/mine/5tt7) | Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK) | Descriptor: | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one, Tyrosine-protein kinase SYK | Authors: | Yano, J, Jennings, A, Lam, B, Hoffman, I.D. | Deposit date: | 2016-11-01 | Release date: | 2016-11-30 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg. Med. Chem. Lett., 26, 2016
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1P7Y
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![BU of 1p7y by Molmil](/molmil-images/mine/1p7y) | Crystal structure of the D181A variant of catalase HPII from E. coli | Descriptor: | Catalase HPII, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chelikani, P, Carpena, X, Fita, I, Loewen, P.C. | Deposit date: | 2003-05-06 | Release date: | 2003-09-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An electrical potential in the access channel of catalases enhances catalysis J.Biol.Chem., 278, 2003
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4QJY
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![BU of 4qjy by Molmil](/molmil-images/mine/4qjy) | Crystal structure of native Ara127N, a GH127 beta-L-arabinofuranosidase from Geobacillus Stearothermophilus T6 | Descriptor: | ACETATE ION, GH127 beta-L-arabinofuranosidase | Authors: | Lansky, S, Salama, R, Dann, R, Shner, I, Manjasetty, B, Belrhali, H, Shoham, Y, Shoham, G. | Deposit date: | 2014-06-05 | Release date: | 2015-06-10 | Method: | X-RAY DIFFRACTION (2.294 Å) | Cite: | Crystal structure of native Ara127N, a GH127 beta-L-arabinofuranosidase from Geobacillus Stearothermophilus T6 To be Published
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1LG9
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![BU of 1lg9 by Molmil](/molmil-images/mine/1lg9) | Crystal structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis | Descriptor: | P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Pylypenko, O, Zerbe, K, Vitali, F, Zhang, W, Vrijbloed, J.W, Robinson, J.A, Schlichting, I. | Deposit date: | 2002-04-15 | Release date: | 2002-12-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis. J.Biol.Chem., 277, 2002
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1LHU
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![BU of 1lhu by Molmil](/molmil-images/mine/1lhu) | CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL | Descriptor: | CALCIUM ION, ESTRADIOL, SEX HORMONE-BINDING GLOBULIN | Authors: | Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Catalano, M.G, Muller, Y.A. | Deposit date: | 2002-04-17 | Release date: | 2002-10-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation J.Biol.Chem., 277, 2002
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1LLB
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![BU of 1llb by Molmil](/molmil-images/mine/1llb) | Crystal Structure Of AmpC beta-Lactamase From E. Coli In Complex With ATMO-penicillin | Descriptor: | 2-{1-[2-(2-AMINO-THIAZOL-4-YL)-2-METHOXYIMINO-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, beta-lactamase | Authors: | Trehan, I, Morandi, F, Blaszczak, L.C, Shoichet, B.K. | Deposit date: | 2002-04-26 | Release date: | 2002-10-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Using steric hindrance to design new inhibitors of class C beta-lactamases. Chem.Biol., 9, 2002
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2CL4
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![BU of 2cl4 by Molmil](/molmil-images/mine/2cl4) | Ascorbate Peroxidase R172A mutant | Descriptor: | ASCORBATE PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | Authors: | Ghamsari, L, MacDonald, I.K, Moody, P.C.E. | Deposit date: | 2006-04-25 | Release date: | 2006-06-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Interaction of Ascorbate Peroxidase with Substrates: A Mechanistic and Structural Analysis. Biochemistry, 45, 2006
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1PTJ
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![BU of 1ptj by Molmil](/molmil-images/mine/1ptj) | Crystal structure analysis of the DI and DIII complex of transhydrogenase with a thio-nicotinamide nucleotide analogue | Descriptor: | GLYCEROL, NAD(P) transhydrogenase subunit alpha part 1, NAD(P) transhydrogenase subunit beta, ... | Authors: | Singh, A, Venning, J.D, Quirk, P.G, van Boxel, G.I, Rodrigues, D.J, White, S.A, Jackson, J.B. | Deposit date: | 2003-06-23 | Release date: | 2003-10-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation J.Biol.Chem., 278, 2003
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1LGF
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![BU of 1lgf by Molmil](/molmil-images/mine/1lgf) | Crystal structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis | Descriptor: | P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Pylypenko, O, Zerbe, K, Vitali, F, Zhang, W, Vrijbloed, J.W, Robinson, J.A, Schlichting, I. | Deposit date: | 2002-04-15 | Release date: | 2002-12-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis. J.Biol.Chem., 277, 2002
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4D60
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![BU of 4d60 by Molmil](/molmil-images/mine/4d60) | Structure of a dimeric Plasmodium falciparum profilin mutant | Descriptor: | PROFILIN, SULFATE ION | Authors: | Bhargav, S.P, Vahokoski, J, Kallio, J.P, Torda, A, Kursula, P, Kursula, I. | Deposit date: | 2014-11-07 | Release date: | 2015-06-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Two Independently Folding Units of Plasmodium Profilin Suggest Evolution Via Gene Fusion. Cell.Mol.Life Sci., 72, 2015
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4R45
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![BU of 4r45 by Molmil](/molmil-images/mine/4r45) | Racemic crystal structure of a bimolecular DNA G-quadruplex (P-1) | Descriptor: | 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R4A
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![BU of 4r4a by Molmil](/molmil-images/mine/4r4a) | Racemic crystal structure of a cobalt-bound B-DNA duplex | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', COBALT (II) ION, SPERMINE | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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1L5F
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![BU of 1l5f by Molmil](/molmil-images/mine/1l5f) | Crystal Structure of CobT complexed with benzimidazole | Descriptor: | BENZIMIDAZOLE, Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, PHOSPHATE ION | Authors: | Cheong, C.-G, Escalante-Semerena, J, Rayment, I. | Deposit date: | 2002-03-06 | Release date: | 2002-09-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural studies of the L-threonine-O-3-phosphate decarboxylase
(CobD) enzyme from Salmonella enterica: the apo, substrate, and
product-aldimine complexes. Biochemistry, 41, 2002
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1LQ1
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![BU of 1lq1 by Molmil](/molmil-images/mine/1lq1) | DNA Complexed Structure of the Key Transcription Factor Initiating Development in Sporulation Bacteria | Descriptor: | 5'-D(*AP*CP*AP*AP*AP*AP*TP*TP*CP*GP*AP*CP*AP*CP*GP*A)-3', 5'-D(*TP*TP*CP*GP*TP*GP*TP*CP*GP*AP*AP*TP*TP*TP*TP*G)-3', Stage 0 sporulation protein A | Authors: | Zhao, H, Msadek, T, Zapf, J, Madhusudan, Hoch, J.A, Varughese, K.I. | Deposit date: | 2002-05-08 | Release date: | 2002-08-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | DNA complexed structure of the key transcription factor initiating development in sporulating bacteria. Structure, 10, 2002
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4R5K
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![BU of 4r5k by Molmil](/molmil-images/mine/4r5k) | Crystal structure of the DnaK C-terminus (Dnak-SBD-B) | Descriptor: | CALCIUM ION, Chaperone protein DnaK, SULFATE ION | Authors: | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | Deposit date: | 2014-08-21 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7469 Å) | Cite: | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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2GAR
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![BU of 2gar by Molmil](/molmil-images/mine/2gar) | A PH-DEPENDENT STABLIZATION OF AN ACTIVE SITE LOOP OBSERVED FROM LOW AND HIGH PH CRYSTAL STRUCTURES OF MUTANT MONOMERIC GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION | Authors: | Su, Y, Yamashita, M.M, Greasley, S.E, Mullen, C.A, Shim, J.H, Jennings, P.A, Benkovic, S.J, Wilson, I.A. | Deposit date: | 1998-05-13 | Release date: | 1998-08-12 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. J.Mol.Biol., 281, 1998
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2GF1
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3TV6
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![BU of 3tv6 by Molmil](/molmil-images/mine/3tv6) | Human B-Raf Kinase Domain in Complex with a Methoxypyrazolopyridinyl Benzamide Inhibitor | Descriptor: | 2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide, Serine/threonine-protein kinase B-raf | Authors: | Voegtli, W.C, Sturgis, H.L, Wu, W.-I. | Deposit date: | 2011-09-19 | Release date: | 2011-10-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. ACS Med Chem Lett, 2, 2011
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4D53
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![BU of 4d53 by Molmil](/molmil-images/mine/4d53) | Outer surface protein BB0689 from Borrelia burgdorferi | Descriptor: | BB0689 | Authors: | Brangulis, K, Petrovskis, I, Kazaks, A, Tars, K. | Deposit date: | 2014-11-02 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and Functional Analysis of Bb0689 from Borrelia Burgdorferi, a Member of the Bacterial CAP Superfamily. J.Struct.Biol., 192, 2015
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