6AEG
 
 | | Crystal structure of xCas9 in complex with sgRNA and target DNA (GAT PAM) | | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*GP*AP*TP*TP*AP*TP*TP*G)-3'), DNA nuclease, ... | | Authors: | Guo, M, Ren, K, Zhu, Y, Huang, Z. | | Deposit date: | 2018-08-04 | | Release date: | 2019-03-27 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Structural insights into a high fidelity variant of SpCas9.
Cell Res., 29, 2019
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6AEB
 | | Crystal structure of xCas9 in complex with sgRNA and target DNA (AAG PAM) | | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*AP*AP*GP*TP*AP*TP*TP*G)-3'), DNA Nuclease, ... | | Authors: | Guo, M, Ren, K, Zhu, Y, Huang, Z. | | Deposit date: | 2018-08-04 | | Release date: | 2019-03-27 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.004 Å) | | Cite: | Structural insights into a high fidelity variant of SpCas9.
Cell Res., 29, 2019
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3FA1
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4YS5
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3GCG
 | | crystal structure of MAP and CDC42 complex | | Descriptor: | Cell division control protein 42 homolog, L0028 (Mitochondria associated protein) | | Authors: | Chai, J, Huang, Z, Feng, Y, Wu, X. | | Deposit date: | 2009-02-22 | | Release date: | 2009-07-21 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
Nat.Struct.Mol.Biol., 16, 2009
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3HGA
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3HGD
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3IJK
 | | 5-OMe modified DNA 8mer | | Descriptor: | 5'-D(*GP*(UMS)P*GP*(T5O)P*AP*CP*AP*C)-3' | | Authors: | Sheng, J, Zhang, W, Hassan, A.E.A, Gan, J, Huang, Z. | | Deposit date: | 2009-08-04 | | Release date: | 2009-10-06 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate
Chemistryselect, 8, 2023
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4DSI
 | | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, Se-dGTP and Calcium | | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, CALCIUM ION, DNA, ... | | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | | Deposit date: | 2012-02-19 | | Release date: | 2013-03-27 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
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4DSJ
 | | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, dGTP and Calcium | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA, ... | | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | | Deposit date: | 2012-02-19 | | Release date: | 2013-03-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
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4DSL
 | | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA and Calcium | | Descriptor: | DNA (5'-D(*G*GP*CP*TP*AP*CP*AP*GP*GP*AP*CP*TP*C)-3'), DNA (5'-D(*TP*CP*AP*CP*GP*AP*GP*TP*CP*CP*TP*GP*TP*AP*GP*CP*C)-3'), DNA polymerase, ... | | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | | Deposit date: | 2012-02-19 | | Release date: | 2013-03-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
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6IIJ
 | | Cryo-EM structure of CV-A10 mature virion | | Descriptor: | SPHINGOSINE, VP1, VP2, ... | | Authors: | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | | Deposit date: | 2018-10-06 | | Release date: | 2018-11-07 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Cell Discov, 5, 2019
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6IIO
 | | Cryo-EM structure of CV-A10 native empty particle | | Descriptor: | VP0, VP1, VP3 | | Authors: | Chen, J.H, Ye, X.H, Cong, Y, Huang, Z. | | Deposit date: | 2018-10-07 | | Release date: | 2018-11-07 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Cell Discov, 5, 2019
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4DWI
 | | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with self complementary DNA, Se-dGTP and Calcium | | Descriptor: | 9-METHYLGUANINE, CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), ... | | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | | Deposit date: | 2012-02-24 | | Release date: | 2013-03-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
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4DSK
 | | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, PPi and Calcium | | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*GP*CP*TP*AP*CP*AP*GP*GP*AP*CP*TP*CP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*GP*AP*GP*TP*CP*CP*TP*GP*TP*AP*GP*CP*C)-3'), ... | | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | | Deposit date: | 2012-02-19 | | Release date: | 2013-03-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
To be Published
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4F4N
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4FP6
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3LTU
 | | 5-SeMe-dU containing DNA 8mer | | Descriptor: | 5'-D(*GP*(UMS)P*GP*(T5S)P*AP*CP*AP*C)-3' | | Authors: | Sheng, J, Hassan, A.E.A, Zhang, W, Gan, J, Huang, Z. | | Deposit date: | 2010-02-16 | | Release date: | 2010-03-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate
Chemistryselect, 8, 2023
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5ID6
 | | Structure of Cpf1/RNA Complex | | Descriptor: | Cpf1, MAGNESIUM ION, RNA (5'-R(P*AP*AP*UP*UP*UP*CP*UP*AP*CP*UP*AP*AP*GP*UP*GP*UP*AP*GP*AP*UP*C)-3') | | Authors: | Dong, D, Ren, K, Qiu, X, Wang, J, Huang, Z. | | Deposit date: | 2016-02-24 | | Release date: | 2016-04-27 | | Last modified: | 2016-05-11 | | Method: | X-RAY DIFFRACTION (2.382 Å) | | Cite: | The crystal structure of Cpf1 in complex with CRISPR RNA
Nature, 532, 2016
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5KK5
 | | AsCpf1(E993A)-crRNA-DNA ternary complex | | Descriptor: | CRISPR-associated endonuclease Cpf1, DNA (28-MER), DNA (8-mer), ... | | Authors: | Gao, P, Yang, H, Rajashankar, K.R, Huang, Z, Patel, D.J. | | Deposit date: | 2016-06-21 | | Release date: | 2016-08-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.289 Å) | | Cite: | Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.
Cell Res., 26, 2016
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6VQV
 | | Type I-F CRISPR-Csy complex with its inhibitor AcrF9 | | Descriptor: | AcrF9, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, ... | | Authors: | Zhang, K, Li, S, Pintilie, G, Zhu, Y, Huang, Z, Chiu, W. | | Deposit date: | 2020-02-06 | | Release date: | 2020-03-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.57 Å) | | Cite: | Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VQX
 | | Type I-F CRISPR-Csy complex with its inhibitor AcrF6 | | Descriptor: | AcrF6, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, ... | | Authors: | Zhang, K, Li, S, Pintilie, G, Zhu, Y, Huang, Z, Chiu, W. | | Deposit date: | 2020-02-06 | | Release date: | 2020-03-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VQW
 | | Type I-F CRISPR-Csy complex with its inhibitor AcrF8 | | Descriptor: | AcrF8, CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, ... | | Authors: | Zhang, K, Li, S, Pintilie, G, Zhu, Y, Huang, Z, Chiu, W. | | Deposit date: | 2020-02-06 | | Release date: | 2020-03-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8IAZ
 | | Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex | | Descriptor: | DNA (5'-D(P*AP*CP*AP*TP*GP*GP*AP*CP*CP*AP*TP*CP*AP*GP*CP*TP*CP*CP*TP*AP*AP*TP*GP*G)-3'), DNA (5'-D(P*CP*CP*AP*TP*TP*AP*GP*GP*AP*GP*CP*TP*GP*AP*TP*G)-3'), RNA (207-MER), ... | | Authors: | Yin, M, Zhou, F, Zhu, Y, Huang, Z. | | Deposit date: | 2023-02-09 | | Release date: | 2024-04-17 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs.
Cell Res., 34, 2024
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4KW0
 | | Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification | | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*(1TW)P*CP*G)-3'), MAGNESIUM ION | | Authors: | Jiang, S, Gan, J, Sheng, J, Sun, H, Huang, Z. | | Deposit date: | 2013-05-23 | | Release date: | 2013-07-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification
TO BE PUBLISHED
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