8T51
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![BU of 8t51 by Molmil](/molmil-images/mine/8t51) | Crystal structure of Fab 3.10C2 bound to TREM2 | Descriptor: | 3.10C2 Fab heavy chain, 3.10C2 Fab light chain, ACETATE ION, ... | Authors: | Hsu, P.L, Wallweber, H. | Deposit date: | 2023-06-12 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining To Be Published
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6UH5
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![BU of 6uh5 by Molmil](/molmil-images/mine/6uh5) | Structural basis of COMPASS eCM recognition of the H2Bub nucleosome | Descriptor: | Bre2, DNA (146-MER), H3 N-terminus, ... | Authors: | Hsu, P.L, Shi, H, Zheng, N. | Deposit date: | 2019-09-26 | Release date: | 2019-11-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS. Mol.Cell, 76, 2019
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6UGM
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![BU of 6ugm by Molmil](/molmil-images/mine/6ugm) | Structural basis of COMPASS eCM recognition of an unmodified nucleosome | Descriptor: | Bre2, DNA (146-MER), H3 N-terminus, ... | Authors: | Hsu, P.L, Shi, H, Zheng, N. | Deposit date: | 2019-09-26 | Release date: | 2019-11-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS. Mol.Cell, 76, 2019
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6CHG
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![BU of 6chg by Molmil](/molmil-images/mine/6chg) | Crystal structure of the yeast COMPASS catalytic module | Descriptor: | H3, Histone-lysine N-methyltransferase, H3 lysine-4 specific, ... | Authors: | Hsu, P.L, Li, H, Zheng, N. | Deposit date: | 2018-02-22 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.985 Å) | Cite: | Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Cell, 174, 2018
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4M3O
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![BU of 4m3o by Molmil](/molmil-images/mine/4m3o) | Crystal structure of K.lactis Rtr1 NTD | Descriptor: | KLLA0F12672p, ZINC ION | Authors: | Hsu, P.L, Yang, W, Zheng, N, Varani, G. | Deposit date: | 2013-08-06 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Rtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTD. J.Mol.Biol., 426, 2014
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8VW5
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![BU of 8vw5 by Molmil](/molmil-images/mine/8vw5) | Crystal structure of Cbl-b TKB bound to compound 2 | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ... | Authors: | Yu, C, Murray, J, Hsu, P.L. | Deposit date: | 2024-01-31 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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8VW4
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![BU of 8vw4 by Molmil](/molmil-images/mine/8vw4) | Crystal structure of Cbl-b TKB bound to compound 26 | Descriptor: | (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ... | Authors: | Yu, C, Murray, J, Hsu, P.L. | Deposit date: | 2024-01-31 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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