7EV4
 
 | | Crystal structure of the Lon-like protease MtaLonC with S582A mutation in complex with F-b20-Q | | Descriptor: | Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-20 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7EUY
 | | Crystal structure of the Lon-like protease MtaLonC with D582A mutation in complex with substrate polypeptide | | Descriptor: | ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-19 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7EV6
 | | Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with F-b20-Q | | Descriptor: | Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-20 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7EUX
 | | Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with substrate polypeptide | | Descriptor: | ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION | | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | | Deposit date: | 2021-05-19 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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8K3Y
 | | The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. | | Deposit date: | 2023-07-17 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.42 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7W1G
 | | Crystal structure of YfiH with C107A mutation in complex with UDP-MurNAc-L-Serine | | Descriptor: | (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, (2S)-2-[[(2R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-2-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-6-(hydroxymethyl)-5-oxidanyl-oxan-4-yl]oxypropanoyl]amino]-3-oxidanyl-propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Lee, S.H, Hsieh, K.Y, Lee, M.S, Chang, C.I. | | Deposit date: | 2021-11-19 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structural Basis for the Peptidoglycan-Editing Activity of YfiH.
Mbio, 13, 2021
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7YPI
 | | Spiral hexamer of the substrate-free Lon protease with a Y224S mutation | | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YPJ
 | | Spiral pentamer of the substrate-free Lon protease with a S678A mutation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YPH
 | | Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YPK
 | | Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein | | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | | Deposit date: | 2022-08-03 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7F3V
 | | Crystal structure of YfiH with C107A mutation in complex with endogenous UDP-MurNAc | | Descriptor: | (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ... | | Authors: | Lee, M.S, Hsieh, K.Y, Chang, C.I. | | Deposit date: | 2021-06-17 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structural Basis for the Peptidoglycan-Editing Activity of YfiH.
Mbio, 13, 2021
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