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PDB: 27 件
5H4J
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BU of 5h4j by Molmil
Crystal structure of Human dUTPase in complex with N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide
分子名称: DIMETHYL SULFOXIDE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, ...
著者Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M.
登録日2016-11-01
公開日2017-11-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.
Mol. Cancer Ther., 17, 2018
3ARN
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BU of 3arn by Molmil
Human dUTPase in complex with novel uracil derivative
分子名称: Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide
著者Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M.
登録日2010-12-03
公開日2010-12-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
J.Med.Chem., 55, 2012
3ARA
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BU of 3ara by Molmil
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
分子名称: 1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione, Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION
著者Chong, K.T, Miyakoshi, H, Miyahara, S, Fukuoka, M.
登録日2010-11-25
公開日2010-12-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors
J.Med.Chem., 55, 2012
1CG5
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BU of 1cg5 by Molmil
DEOXY FORM HEMOGLOBIN FROM DASYATIS AKAJEI
分子名称: PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
著者Chong, K.T, Morimoto, H.
登録日1999-03-26
公開日1999-04-01
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish.
Acta Crystallogr.,Sect.D, 55, 1999
1CG8
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BU of 1cg8 by Molmil
CO Form Hemoglobin from Dasyatis Akajei
分子名称: CARBON MONOXIDE, PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
著者Chong, K.T, Morimoto, H.
登録日1999-03-26
公開日1999-04-01
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish.
Acta Crystallogr.,Sect.D, 55, 1999
3WQ9
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BU of 3wq9 by Molmil
Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide
分子名称: 2-[(trans-4-hydroxycyclohexyl)amino]-4-[5-(4-phenyl-1H-imidazol-1-yl)isoquinolin-1-yl]benzamide, Heat shock protein HSP 90-alpha
著者Chong, K.T, Yamashita, S, Oshiumi, H, Uno, T, Kitade, M.
登録日2014-01-23
公開日2015-02-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Evolution of highly selective Hsp90 / inhibitors by structure and thermodynamics guided design
To be Published
3R21
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BU of 3r21 by Molmil
Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
分子名称: MAGNESIUM ION, N-(2-aminoethyl)-N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, Serine/threonine-protein kinase 6
著者Zhang, L, Fan, J, Chong, J.-H, Cesena, A, Tam, B, Gilson, C, Boykin, C, Wang, D, Marcotte, D, Le Brazidec, J.-Y, Aivazian, D, Piao, J, Lundgren, K, Hong, K, Vu, K, Nguyen, K.
登録日2011-03-11
公開日2011-08-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
3R22
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Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
分子名称: N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, Serine/threonine-protein kinase 6
著者Zhang, L, Fan, J, Chong, J.-H, Cesana, A, Tam, B, Gilson, C, Boykin, C, Wang, D, Marcotte, D, Le Brazidec, J.-Y, Aivazian, D, Piao, J, Lundgren, K, Hong, K, Vu, K, Nguyen, K.
登録日2011-03-11
公開日2011-08-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
3L1N
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BU of 3l1n by Molmil
Crystal structure of Mp1p ligand binding domain 2 complexd with palmitic acid
分子名称: Cell wall antigen, PALMITIC ACID
著者Liao, S, Tung, E.T, Zheng, W, Chong, K, Xu, Y, Bartlam, M, Rao, Z, Yuen, K.Y.
登録日2009-12-14
公開日2010-01-05
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein.
J.Biol.Chem., 285, 2010
1K9A
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BU of 1k9a by Molmil
Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution
分子名称: Carboxyl-terminal Src kinase
著者Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T.
登録日2001-10-28
公開日2002-03-20
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the carboxyl-terminal Src kinase, Csk.
J.Biol.Chem., 277, 2002
5ZR3
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BU of 5zr3 by Molmil
Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide
分子名称: 3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide, Heat shock protein HSP 90-alpha
著者Uno, T, Chong, K.T, Suzuki, T.
登録日2018-04-23
公開日2019-01-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
J. Med. Chem., 62, 2019
1UHI
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BU of 1uhi by Molmil
Crystal structure of i-aequorin
分子名称: (2R)-8-BENZYL-2-HYDROPEROXY-6-(4-HYDROXYPHENYL)-2-(4-IODOBENZYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE, Aequorin 2
著者Toma, S, Chong, K.T, Nakagawa, A, Teranishi, K, Inouye, S, Shimomura, O.
登録日2003-07-03
公開日2005-02-08
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1UHJ
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BU of 1uhj by Molmil
Crystal structure of br-aequorin
分子名称: (2S,8R)-8-BENZYL-2-(4-BROMOBENZYL)-2-HYDROPEROXY-6-(4-HYDROXYPHENYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE, Aequorin 2
著者Toma, S, Chong, K.T, Nakagawa, A, Teranishi, K, Inouye, S, Shimomura, O.
登録日2003-07-03
公開日2005-02-08
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1UHK
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BU of 1uhk by Molmil
Crystal structure of n-aequorin
分子名称: (2S,8R)-8-BENZYL-2-HYDROPEROXY-6-(4-HYDROXYPHENYL)-2-(2-NAPHTHYLMETHYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE, Aequorin 2
著者Toma, S, Chong, K.T, Nakagawa, A, Teranishi, K, Inouye, S, Shimomura, O.
登録日2003-07-03
公開日2005-02-08
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1UHH
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BU of 1uhh by Molmil
Crystal structure of cp-aequorin
分子名称: (8R)-8-(CYCLOPENTYLMETHYL)-2-HYDROPEROXY-2-(4-HYDROXYBENZYL)-6-(4-HYDROXYPHENYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H) -ONE, Aequorin 2
著者Toma, S, Chong, K.T, Nakagawa, A, Teranishi, K, Inouye, S, Shimomura, O.
登録日2003-07-03
公開日2005-02-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1V4W
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BU of 1v4w by Molmil
Crystal structure of bluefin tuna hemoglobin deoxy form at pH7.5
分子名称: PROTOPORPHYRIN IX CONTAINING FE, hemoglobin alpha chain, hemoglobin beta chain
著者Yokoyama, T, Chong, K.T, Miyazaki, Y, Nakatsukasa, T, Unzai, S, Miyazaki, G, Morimoto, H, Jeremy, R.H.T, Park, S.Y.
登録日2003-11-19
公開日2004-07-06
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
2Q5C
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BU of 2q5c by Molmil
Crystal structure of NtrC family transcriptional regulator from Clostridium acetobutylicum
分子名称: GLYCEROL, NtrC family transcriptional regulator, SULFATE ION
著者Ramagopal, U.A, Dickey, M, Toro, R, Iizuka, M, Groshong, K, Rodgers, L, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2007-05-31
公開日2007-07-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Crystal structure of NtrC family transcriptional regulator from Clostridium acetobutylicum.
To be Published
1GCV
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BU of 1gcv by Molmil
DEOXY FORM HEMOGLOBIN FROM MUSTELUS GRISEUS
分子名称: HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
著者Naoi, Y, Chong, K.T, Yoshimatsu, K, Miyazaki, G, Tame, J.R.H, Park, S.Y, Adachi, S.I, Morimoto, H.
登録日2000-08-08
公開日2000-08-31
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The functional similarity and structural diversity of human and cartilaginous fish hemoglobins.
J.Mol.Biol., 307, 2001
1GCW
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CO form hemoglobin from mustelus griseus
分子名称: CARBON MONOXIDE, PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
著者Naoi, Y, Chong, K.T, Yoshimatsu, K, Miyazaki, G, Tame, J.R.H, Park, S.Y, Adachi, S.I, Morimoto, H.
登録日2000-08-08
公開日2000-09-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The functional similarity and structural diversity of human and cartilaginous fish hemoglobins.
J.Mol.Biol., 307, 2001
1V4U
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BU of 1v4u by Molmil
Crystal structure of bluefin tuna carbonmonoxy-hemoglobin
分子名称: CARBON MONOXIDE, PROTOPORPHYRIN IX CONTAINING FE, hemoglobin alpha chain, ...
著者Yokoyama, T, Chong, K.T, Miyazaki, Y, Nakatsukasa, T, Unzai, S, Miyazaki, G, Morimoto, H, Jeremy, R.H.T, Park, S.Y.
登録日2003-11-19
公開日2004-07-06
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
1V4X
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BU of 1v4x by Molmil
Crystal structure of bluefin tuna hemoglobin deoxy form at pH5.0
分子名称: PROTOPORPHYRIN IX CONTAINING FE, hemoglobin alpha chain, hemoglobin beta chain
著者Yokoyama, T, Chong, K.T, Miyazaki, Y, Nakatsukasa, T, Unzai, S, Miyazaki, G, Morimoto, H, Jeremy, R.H.T, Park, S.Y.
登録日2003-11-19
公開日2004-07-06
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
2E0Z
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BU of 2e0z by Molmil
Crystal structure of virus-like particle from Pyrococcus furiosus
分子名称: Virus-like particle
著者Akita, F, Chong, K.T, Tanaka, H, Yamashita, E, Miyazaki, N, Nakaishi, Y, Namba, K, Ono, Y, Suzuki, M, Tsukihara, T, Nakagawa, A.
登録日2006-10-16
公開日2007-04-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献The Crystal Structure of a Virus-like Particle from the Hyperthermophilic Archaeon Pyrococcus furiosus Provides Insight into the Evolution of Viruses
J.Mol.Biol., 368, 2007
1IT3
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BU of 1it3 by Molmil
Hagfish CO ligand hemoglobin
分子名称: CARBON MONOXIDE, PROTOPORPHYRIN IX CONTAINING FE, hemoglobin
著者Mito, M, Chong, K.T, Park, S.-Y, Tame, J.R.
登録日2002-01-05
公開日2002-01-23
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeri
J.Biol.Chem., 277, 2002
6L3R
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BU of 6l3r by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
分子名称: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ...
著者Miyahara, S, Chong, K.T, Suzuki, T.
登録日2019-10-15
公開日2020-10-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6L7L
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BU of 6l7l by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide
分子名称: 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ...
著者Miyahara, S, Chong, K.T, Suzuki, T.
登録日2019-11-01
公開日2020-11-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.171 Å)
主引用文献TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published

 

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