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PDB: 300 件
2B9S
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Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex
分子名称: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', 5'-D(*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ...
著者Davies, D.R, Hol, W.G.J.
登録日2005-10-12
公開日2006-01-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
J.Mol.Biol., 357, 2006
2AUC
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Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor
分子名称: Myosin A, Myosin A Tail Interacting Protein
著者Bosch, J, Turley, S, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-08-27
公開日2006-01-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2EPH
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Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.7 angstrom resolution
分子名称: Fructose-bisphosphate aldolase, PbTRAP
著者Bosch, J, Buscaglia, C.A, Krumm, B, Cardozo, T, Nussenzweig, V, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2007-03-30
公開日2007-04-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4ZT7
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N'-(5-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1717)
分子名称: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-05-14
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
4ZT6
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1709)
分子名称: DIMETHYL SULFOXIDE, METHIONINE, Methionyl-tRNA synthetase, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-05-14
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
4ZT2
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1575)
分子名称: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-05-14
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
4ZT3
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1614)
分子名称: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-05-14
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
4ZT4
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitorN-(3,5-dichlorobenzyl)-2,2-difluoro-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1708)
分子名称: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-05-14
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
4ZT5
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Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655)
分子名称: (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-05-14
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
1FWZ
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GLU20ALA DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR, SULFATE ION, ZINC ION
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-09-25
公開日2001-09-25
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G3T
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CYS102SER DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G3S
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CYS102SER DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G3Y
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ARG80ALA DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR, ZINC ION
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G3W
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CD-CYS102SER DTXR
分子名称: CADMIUM ION, DIPHTHERIA TOXIN REPRESSOR, SULFATE ION
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
2BH1
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X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae
分子名称: CALCIUM ION, GENERAL SECRETION PATHWAY PROTEIN E,, GENERAL SECRETION PATHWAY PROTEIN L
著者Abendroth, J, Murphy, P.M, Mushtaq, A, Bagdasarian, M, Sandkvist, M, Hol, W.G.J.
登録日2005-01-06
公開日2005-05-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The X-Ray Structure of the Type II Secretion System Complex Formed by the N-Terminal Domain of Epse and the Cytoplasmic Domain of Epsl of Vibrio Cholerae
J.Mol.Biol., 348, 2005
1XQ9
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Structure of Phosphoglycerate Mutase from Plasmodium falciparum at 2.6 Resolution
分子名称: THIOCYANATE ION, phosphoglycerate mutase
著者Caruthers, J.M, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-10-11
公開日2004-12-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structure of Phosphoglycerate Mutase from Plasmodium falciparum at 2.6 Resolution
TO BE PUBLISHED
1XIQ
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Plasmodium falciparum Nucleoside diphosphate kinase B
分子名称: Nucleoside diphosphate kinase B
著者Robien, M.A, Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-09-21
公開日2004-10-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal structure of Nucleoside diphosphate kinase B from Plasmodium falciparum
To be Published
1XO7
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Crystal structure of cyclophilin from Trypanosoma cruzi
分子名称: cyclophilin
著者Caruthers, J.M, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-10-05
公開日2004-12-21
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Crystal structure of cyclophilin from Trypanosoma cruzi
TO BE PUBLISHED
1YJ8
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Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase
分子名称: glycerol-3-phosphate dehydrogenase
著者Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-01-13
公開日2005-02-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase
To be Published
2BTM
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DOES THE HIS12-LYS13 PAIR PLAY A ROLE IN THE ADAPTATION OF THERMOPHILIC TIMS TO HIGH TEMPERATURES?
分子名称: 2-PHOSPHOGLYCOLIC ACID, PROTEIN (TRIOSEPHOSPHATE ISOMERASE)
著者Delboni, L.F, Mande, S.C, Hol, W.G.J.
登録日1999-01-04
公開日1999-01-13
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Lys13 plays a crucial role in the functional adaptation of the thermophilic triose-phosphate isomerase from Bacillus stearothermophilus to high temperatures.
J.Biol.Chem., 274, 1999
1W97
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cyto-EpsL: the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae
分子名称: TYPE II SECRETION SYSTEM PROTEIN L
著者Abendroth, J, Bagdasarian, M, Sansdkvist, M, Hol, W.G.J.
登録日2004-10-06
公開日2004-11-30
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Structure of the Cytoplasmic Domain of Epsl, an Inner Membrane Component of the Type II Secretion System of Vibrio Cholerae: An Unusual Member of the Actin-Like ATPase Superfamily
J.Mol.Biol., 344, 2004
2AF6
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Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)
分子名称: 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Sampathkumar, P, Turley, S, Ulmer, J.E, Rhie, H.G, Sibley, C.H, Hol, W.G.
登録日2005-07-25
公開日2005-10-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0A Resolution.
J.Mol.Biol., 352, 2005
2A0S
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Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution
分子名称: 6-pyruvoyl tetrahydropterin synthase, BIOPTERIN, ZINC ION
著者Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2005-06-16
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution
To be Published
1XQ7
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Cyclophilin from Trypanosoma cruzi bound to cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Caruthers, J.M, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-10-11
公開日2004-12-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Cyclophilin from Trypanosoma Cruzi Bound to Cyclosporin A
To be Published
1XTD
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Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a
分子名称: eukaryotic initiation factor 5a
著者Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-10-21
公開日2004-10-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a
To be Published

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