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PDB: 162 件
2TCT
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THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE
分子名称: 7-CHLOROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
著者Hinrichs, W, Kisker, C, Saenger, W.
登録日1995-03-02
公開日1996-04-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.
J.Mol.Biol., 247, 1995
2TRT
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TETRACYCLINE REPRESSOR CLASS D
分子名称: MAGNESIUM ION, TETRACYCLINE, TETRACYCLINE REPRESSOR CLASS D
著者Hinrichs, W, Kisker, C, Saenger, W.
登録日1994-03-04
公開日1996-06-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
5MRU
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TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
分子名称: 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, Tetracycline Repressor, ...
著者Hinrichs, W, Palm, G.J.
登録日2016-12-26
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
To Be Published
6RBM
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TETR(D) E147A MUTANT IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM
分子名称: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-04-11
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RCR
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TETR(D) H100A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
分子名称: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-04-11
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6QJX
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TetR(D) T103A mutant in complex with minocycline and magnesium
分子名称: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-01-27
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6QJW
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TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium
分子名称: 7-CHLOROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-01-27
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RBL
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TETR(D) E147A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
分子名称: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-04-10
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RGX
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TETR(D) N82A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
分子名称: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-04-17
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6YR2
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TetR(D) soaked with Tigecycline P4(1)2(1)2
分子名称: CHLORIDE ION, MAGNESIUM ION, SULFATE ION, ...
著者Hinrichs, W, Stary, K.
登録日2020-04-19
公開日2021-04-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献TetR(D) soaked with Tigecycline
to be published
6YR1
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BU of 6yr1 by Molmil
TetR(D) soaked with Tigecycline I4(1)22
分子名称: CHLORIDE ION, MAGNESIUM ION, TIGECYCLINE, ...
著者Hinrichs, W, Stary, K.
登録日2020-04-18
公開日2021-04-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献TetR(D) soaked with Tigecycline
to be published
6FPM
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BU of 6fpm by Molmil
TetR(D) T103A mutant in complex with tetracycline and magnesium
分子名称: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2018-02-11
公開日2019-03-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FPL
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BU of 6fpl by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM
分子名称: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2018-02-11
公開日2019-03-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FTS
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BU of 6fts by Molmil
TETR(D) N82A MUTANT IN COMPLEX WITH PEG4
分子名称: CHLORIDE ION, TETRAETHYLENE GLYCOL, Tetracycline repressor protein class D
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2018-02-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
8B7R
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BU of 8b7r by Molmil
Bacterial chalcone isomerase with taxifolin chalcone
分子名称: (Z)-3-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-1-[2,4,6-tris(oxidanyl)phenyl]prop-2-en-1-one, CHLORIDE ION, Chalcone isomerase, ...
著者Hinrichs, W, Palm, G.J.
登録日2022-10-02
公開日2022-11-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus .
Molecules, 27, 2022
8B7U
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Bacterial chalcone isomerase H33A with taxifolin
分子名称: (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, CHLORIDE ION, Chalcone isomerase, ...
著者Hinrichs, W, Palm, G.J.
登録日2022-10-03
公開日2022-11-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus .
Molecules, 27, 2022
4V08
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BU of 4v08 by Molmil
Inhibited dimeric pseudorabies virus protease pUL26N at 2 A resolution
分子名称: CHLORIDE ION, DIISOPROPYL PHOSPHONATE, MAGNESIUM ION, ...
著者Zuehlsdorf, M, Werten, S, Palm, G.J, Hinrichs, W.
登録日2014-09-11
公開日2015-07-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin Pul26N, a Herpesvirus Serine Protease
Plos Pathog., 11, 2015
7NFV
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BU of 7nfv by Molmil
Structure of SARS-CoV-2 Papain-like protease PLpro
分子名称: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
著者Srinivasan, V, Gunther, S, Reinke, P, Werner, N, Falke, S, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Sprenger, J, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Koua, F, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Ewert, W, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Ehrt, C, Rarey, M, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Hinrichs, W, Meents, A, Betzel, C.
登録日2021-02-07
公開日2021-02-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
5A4N
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Crystal structure of BPSL1147, a PC4 homolog from Burkholderia pseudomallei K96243 (tetragonal crystal form)
分子名称: BPSL1147, CHLORIDE ION
著者Werten, S, Bayer, N, Hinrichs, W.
登録日2015-06-11
公開日2016-04-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structural Analysis and Knock-Out of a Burkholderia Pseudomallei Homolog of the Eukaryotic Transcription Coactivator Pc4.
Gene, 557, 2016
2FJ1
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BU of 2fj1 by Molmil
Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II)
分子名称: 7-CHLOROTETRACYCLINE, CHLORIDE ION, NICKEL (II) ION, ...
著者Orth, P, Saenger, W, Palm, G.J, Hinrichs, W.
登録日2005-12-30
公開日2007-01-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex.
J.Biol.Inorg.Chem., 13, 2008
1ORK
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TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE
分子名称: 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
著者Orth, P, Schnappinger, D, Sum, P.-E, Ellestad, G.A, Hillen, W, Saenger, W, Hinrichs, W.
登録日1998-05-21
公開日1999-06-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
J.Mol.Biol., 285, 1999
7Z3U
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BU of 7z3u by Molmil
Crystal structure of SARS-CoV-2 Main Protease after incubation with Sulfo-Calpeptin
分子名称: 3C-like proteinase nsp5, CHLORIDE ION, Calpetin, ...
著者Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
7Z58
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BU of 7z58 by Molmil
Crystal structure of human Cathepsin L in complex with covalently bound Calpeptin
分子名称: 1,2-ETHANEDIOL, Calpeptin, Cathepsin L, ...
著者Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
登録日2022-03-08
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
7Z3T
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Crystal structure of apo human Cathepsin L
分子名称: 1,2-ETHANEDIOL, Cathepsin L, DI(HYDROXYETHYL)ETHER, ...
著者Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
登録日2022-03-02
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Commun Biol, 6, 2023
7Z2K
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Crystal structure of SARS-CoV-2 Main Protease in orthorhombic space group p212121
分子名称: 3C-like proteinase nsp5, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A.
登録日2022-02-28
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections
To Be Published

222624

件を2024-07-17に公開中

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