6OIR
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![BU of 6oir by Molmil](/molmil-images/mine/6oir) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 62 | 分子名称: | 4-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
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7M5Z
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![BU of 7m5z by Molmil](/molmil-images/mine/7m5z) | Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692 | 分子名称: | 2-(butylamino)-N-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide, Tyrosine-protein kinase Mer | 著者 | Hermans, S.J, Hancock, N.C, Baell, J.B, Parker, M.W. | 登録日 | 2021-03-25 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Development of [ 18 F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease. Eur.J.Med.Chem., 226, 2021
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4XXD
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![BU of 4xxd by Molmil](/molmil-images/mine/4xxd) | Crystal Structure of mid-region amyloid beta capture by solanezumab | 分子名称: | Amyloid-beta fragment, Fab Heavy Chain, Fab Light Chain | 著者 | Hermans, S.J, Crespi, G.A.N, Parker, M.W, Miles, L.A. | 登録日 | 2015-01-30 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies. Sci Rep, 5, 2015
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4P8Q
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![BU of 4p8q by Molmil](/molmil-images/mine/4p8q) | Crystal Structure of Human Insulin Regulated Aminopeptidase with Alanine in Active Site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ... | 著者 | Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W. | 登録日 | 2014-03-31 | 公開日 | 2014-12-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Sci., 24, 2015
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4PJ6
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![BU of 4pj6 by Molmil](/molmil-images/mine/4pj6) | Crystal Structure of Human Insulin Regulated Aminopeptidase with Lysine in Active Site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LYSINE, ... | 著者 | Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W. | 登録日 | 2014-05-12 | 公開日 | 2014-12-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Sci., 24, 2015
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6BA2
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![BU of 6ba2 by Molmil](/molmil-images/mine/6ba2) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor | 分子名称: | 4-fluoro-5-methyl-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, CHLORIDE ION, GLYCEROL, ... | 著者 | Hermans, S.J, Chung, M.C, Peat, T.S, Baell, J.B, Thomas, T, Parker, M.W. | 登録日 | 2017-10-11 | 公開日 | 2018-08-01 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (1.85003817 Å) | 主引用文献 | Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature, 560, 2018
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6BA4
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![BU of 6ba4 by Molmil](/molmil-images/mine/6ba4) | Crystal structure of MYST acetyltransferase domain in complex with Acetyl-CoA cofactor | 分子名称: | ACETYL COENZYME *A, Histone acetyltransferase KAT8, S-{(3S,5R,9R)-1-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} ethanethioate, ... | 著者 | Hermans, S.J, Chung, M.C, Peat, T.S, Baell, J.B, Thomas, T, Parker, M.W. | 登録日 | 2017-10-12 | 公開日 | 2018-08-01 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (1.949 Å) | 主引用文献 | Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature, 560, 2018
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4DXF
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![BU of 4dxf by Molmil](/molmil-images/mine/4dxf) | Crystal structure of Staphylococcal Superantigen-Like protein 4 | 分子名称: | CHLORIDE ION, GLYCEROL, Staphylococcal enterotoxin-like toxin | 著者 | Hermans, S.J, Baker, H.M, Langley, R.J, Baker, E.N, Fraser, J.F. | 登録日 | 2012-02-27 | 公開日 | 2012-09-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and functional properties of staphylococcal superantigen-like protein 4 Infect.Immun., 80, 2012
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4DXG
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![BU of 4dxg by Molmil](/molmil-images/mine/4dxg) | Crystal structure of Staphylococcal Superantigen-Like protein 4 complexed with sialyl Lewis X | 分子名称: | CHLORIDE ION, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), ... | 著者 | Hermans, S.J, Baker, H.M, Langley, R.J, Baker, E.N, Fraser, J.F. | 登録日 | 2012-02-27 | 公開日 | 2012-09-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and functional properties of staphylococcal superantigen-like protein 4 Infect.Immun., 80, 2012
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6D49
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![BU of 6d49 by Molmil](/molmil-images/mine/6d49) | Cell Surface Receptor in Complex with Ligand at 1.80-A Resolution | 分子名称: | 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, GLYCEROL, Myeloid cell surface antigen CD33 | 著者 | Hermans, S.J, Miles, L.A, Parker, M.W. | 登録日 | 2018-04-17 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19, 2019
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6D4A
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![BU of 6d4a by Molmil](/molmil-images/mine/6d4a) | Cell Surface Receptor with Bound Ligand at 1.75-A Resolution | 分子名称: | 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, GLYCEROL, Myeloid cell surface antigen CD33 | 著者 | Hermans, S.J, Miles, L.A, Parker, M.W. | 登録日 | 2018-04-17 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | 主引用文献 | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19, 2019
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6D48
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![BU of 6d48 by Molmil](/molmil-images/mine/6d48) | Cell Surface Receptor | 分子名称: | Myeloid cell surface antigen CD33 | 著者 | Hermans, S.J, Miles, L.A, Parker, M.W. | 登録日 | 2018-04-17 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.776 Å) | 主引用文献 | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes A beta Phagocytosis. Iscience, 19, 2019
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6OIO
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![BU of 6oio by Molmil](/molmil-images/mine/6oio) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 | 分子名称: | Histone acetyltransferase KAT8, N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, ZINC ION | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
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6OIQ
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![BU of 6oiq by Molmil](/molmil-images/mine/6oiq) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 63 | 分子名称: | 2-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
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6OIP
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![BU of 6oip by Molmil](/molmil-images/mine/6oip) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 34 | 分子名称: | 2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-04-09 | 公開日 | 2019-07-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
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6PDG
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![BU of 6pdg by Molmil](/molmil-images/mine/6pdg) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83 | 分子名称: | 5-ethoxy-2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.919 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PDA
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![BU of 6pda by Molmil](/molmil-images/mine/6pda) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 74 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyridin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.448 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PDE
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![BU of 6pde by Molmil](/molmil-images/mine/6pde) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-propoxybenzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PD8
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![BU of 6pd8 by Molmil](/molmil-images/mine/6pd8) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 39 | 分子名称: | 5-ethoxy-2-fluoro-3-methyl-N'-(phenylsulfonyl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.738 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PDC
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![BU of 6pdc by Molmil](/molmil-images/mine/6pdc) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 42 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(prop-2-en-1-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PD9
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![BU of 6pd9 by Molmil](/molmil-images/mine/6pd9) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(1H-pyrazol-1-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PDF
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![BU of 6pdf by Molmil](/molmil-images/mine/6pdf) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 55 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(2H-1,2,3-triazol-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PDB
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![BU of 6pdb by Molmil](/molmil-images/mine/6pdb) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 80 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyrimidin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6PDD
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![BU of 6pdd by Molmil](/molmil-images/mine/6pdd) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 41 | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(propan-2-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-06-18 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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6OWH
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![BU of 6owh by Molmil](/molmil-images/mine/6owh) | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase KAT8, ... | 著者 | Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. | 登録日 | 2019-05-09 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
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