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PDB: 12 件
3C0T
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BU of 3c0t by Molmil
Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18
分子名称: Mediator of RNA polymerase II transcription subunit 18, Mediator of RNA polymerase II transcription subunit 8
著者Lariviere, L, Seizl, M, van Wageningen, S, Roether, S, van de Pasch, L, Feldmann, H, Straesser, K, Hahn, S, Holstege, C.P, Cramer, P.
登録日2008-01-21
公開日2008-04-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-system correlation identifies a gene regulatory Mediator submodule
Genes Dev., 22, 2008
1YTB
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BU of 1ytb by Molmil
CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX
分子名称: DNA (29MER), PROTEIN (TATA BINDING PROTEIN (TBP))
著者Kim, Y, Geiger, J.H, Hahn, S, Sigler, P.B.
登録日1994-09-28
公開日1995-01-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a yeast TBP/TATA-box complex.
Nature, 365, 1993
2LPB
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BU of 2lpb by Molmil
Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15
分子名称: General control protein GCN4, Mediator of RNA polymerase II transcription subunit 15
著者Brzovic, P.S, Heikaus, C.C, Kisselev, L, Vernon, R, Herbig, E, Pacheco, D, Warfield, L, Littlefield, P, Baker, D, Klevit, R.E, Hahn, S.
登録日2012-02-07
公開日2012-02-22
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.
Mol.Cell, 44, 2011
6MZC
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BU of 6mzc by Molmil
Human TFIID BC core
分子名称: Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 2, ...
著者Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZM
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BU of 6mzm by Molmil
Human TFIID bound to promoter DNA and TFIIA
分子名称: SCP DNA (80-MER), TATA-box-binding protein, Transcription initiation factor IIA subunit 1, ...
著者Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZD
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BU of 6mzd by Molmil
Human TFIID Lobe A canonical
分子名称: TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ...
著者Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (9.8 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZL
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BU of 6mzl by Molmil
Human TFIID canonical state
分子名称: TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ...
著者Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (23 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6ALY
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BU of 6aly by Molmil
Solution structure of yeast Med15 ABD2 residues 277-368
分子名称: Mediator of RNA polymerase II transcription subunit 15
著者Tuttle, L.M, Pacheco, D, Warfield, L, Hahn, S, Klevit, R.E.
登録日2017-08-08
公開日2018-03-21
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
Cell Rep, 22, 2018
4JV8
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BU of 4jv8 by Molmil
The crystal structure of PDE6D in complex with rac-S1
分子名称: (6R)-6-(pyridin-2-yl)-5,6-dihydrobenzimidazo[1,2-c]quinazoline, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
著者Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVB
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BU of 4jvb by Molmil
Crystal structure of PDE6D in complex with the inhibitor rac-2
分子名称: 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
著者Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JV6
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BU of 4jv6 by Molmil
The crystal structure of PDE6D in complex to inhibitor-1
分子名称: 1-benzyl-2-phenyl-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
著者Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVF
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BU of 4jvf by Molmil
The Crystal structure of PDE6D in complex with the inhibitor (s)-5
分子名称: (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
著者Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013

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件を2024-11-20に公開中

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