2VJ8
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![BU of 2vj8 by Molmil](/molmil-images/mine/2vj8) | Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor | 分子名称: | 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ... | 著者 | Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z. | 登録日 | 2007-12-07 | 公開日 | 2008-01-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors Faseb J., 16, 2002
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2UUI
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![BU of 2uui by Molmil](/molmil-images/mine/2uui) | Crystal structure of Human Leukotriene C4 Synthase | 分子名称: | DODECYL-BETA-D-MALTOSIDE, LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, ... | 著者 | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | 登録日 | 2007-03-02 | 公開日 | 2007-07-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448, 2007
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2UUH
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![BU of 2uuh by Molmil](/molmil-images/mine/2uuh) | Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione | 分子名称: | DODECYL-ALPHA-D-MALTOSIDE, GLUTATHIONE, LEUKOTRIENE C4 SYNTHASE, ... | 著者 | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | 登録日 | 2007-03-02 | 公開日 | 2007-07-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448, 2007
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6SSW
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![BU of 6ssw by Molmil](/molmil-images/mine/6ssw) | |
6SSR
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![BU of 6ssr by Molmil](/molmil-images/mine/6ssr) | |
1HS6
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![BU of 1hs6 by Molmil](/molmil-images/mine/1hs6) | STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN. | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ... | 著者 | Thunnissen, M.M.G.M, Nordlund, P.N, Haeggstrom, J.Z. | 登録日 | 2000-12-24 | 公開日 | 2001-06-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat.Struct.Biol., 8, 2001
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4JRZ
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![BU of 4jrz by Molmil](/molmil-images/mine/4jrz) | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-03-22 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
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4JCZ
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![BU of 4jcz by Molmil](/molmil-images/mine/4jcz) | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-02-22 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
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4JC7
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![BU of 4jc7 by Molmil](/molmil-images/mine/4jc7) | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-02-21 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
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4J7T
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![BU of 4j7t by Molmil](/molmil-images/mine/4j7t) | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | 分子名称: | D-gamma-glutamyl-S-(4-phenylbutyl)-L-cysteinylglycine, Leukotriene C4 synthase, NICKEL (II) ION, ... | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-02-14 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.203 Å) | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
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4J7Y
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![BU of 4j7y by Molmil](/molmil-images/mine/4j7y) | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | 分子名称: | D-gamma-glutamyl-(Z)-N-(carboxymethylidene)-S-[(2R)-2-hydroxy-4-phenylbutyl]-L-cysteinamide, Leukotriene C4 synthase, NICKEL (II) ION, ... | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-02-14 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
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4L2L
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![BU of 4l2l by Molmil](/molmil-images/mine/4l2l) | Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine | 分子名称: | 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETATE ION, Leukotriene A-4 hydrolase, ... | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-06-04 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
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1SQM
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![BU of 1sqm by Molmil](/molmil-images/mine/1sqm) | STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE | 分子名称: | ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ... | 著者 | Tholander, F.O.T, Rudberg, P.C, Thunnissen, M.M.G.M, Haeggstrom, J.Z. | 登録日 | 2004-03-19 | 公開日 | 2004-08-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates J.Biol.Chem., 279, 2004
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2XPY
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![BU of 2xpy by Molmil](/molmil-images/mine/2xpy) | Structure of Native Leukotriene A4 Hydrolase from Saccharomyces cerevisiae | 分子名称: | GLUTATHIONE, GLYCEROL, LEUKOTRIENE A-4 HYDROLASE, ... | 著者 | Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. | 登録日 | 2010-08-31 | 公開日 | 2010-12-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
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