3HXC
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![BU of 3hxc by Molmil](/molmil-images/mine/3hxc) | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8) | Descriptor: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | Authors: | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | Deposit date: | 2009-06-20 | Release date: | 2009-09-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
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3HXF
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![BU of 3hxf by Molmil](/molmil-images/mine/3hxf) | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 32) | Descriptor: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | Authors: | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | Deposit date: | 2009-06-20 | Release date: | 2009-09-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
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3JZ9
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![BU of 3jz9 by Molmil](/molmil-images/mine/3jz9) | Crystal structure of the GEF domain of DrrA/SidM from Legionella pneumophila | Descriptor: | Uncharacterized protein DrrA | Authors: | Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A. | Deposit date: | 2009-09-23 | Release date: | 2010-01-19 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol.Cell, 36, 2009
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3QBT
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![BU of 3qbt by Molmil](/molmil-images/mine/3qbt) | Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp | Descriptor: | Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Hou, X, Hagemann, N, Schoebel, S, Blankenfeldt, W, Goody, R.S, Erdmann, K.S, Itzen, A. | Deposit date: | 2011-01-14 | Release date: | 2011-03-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. Embo J., 30, 2011
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3TNF
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![BU of 3tnf by Molmil](/molmil-images/mine/3tnf) | LidA from Legionella in complex with active Rab8a | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, LidA, MAGNESIUM ION, ... | Authors: | Schoebel, S, Cichy, A.L, Goody, R.S, Itzen, A. | Deposit date: | 2011-09-01 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Protein LidA from Legionella is a Rab GTPase supereffector. Proc.Natl.Acad.Sci.USA, 108, 2011
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3CPI
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![BU of 3cpi by Molmil](/molmil-images/mine/3cpi) | Crystal structure of yeast Rab-GDI | Descriptor: | Rab GDP-dissociation inhibitor | Authors: | Kravchenko, S, Ignatev, A, Goody, R.S, Rak, A, Pylypenko, O. | Deposit date: | 2008-03-31 | Release date: | 2008-05-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J.Biol.Chem., 283, 2008
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3DST
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![BU of 3dst by Molmil](/molmil-images/mine/3dst) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with geranylgeranyl pyrophosphate | Descriptor: | CALCIUM ION, GERANYLGERANYL DIPHOSPHATE, Geranylgeranyl transferase type-2 subunit alpha, ... | Authors: | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | Deposit date: | 2008-07-14 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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3DSV
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![BU of 3dsv by Molmil](/molmil-images/mine/3dsv) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with mono-prenylated peptide Ser-Cys-Ser-Cys(GG) derivated from Rab7 | Descriptor: | CALCIUM ION, GERAN-8-YL GERAN, Geranylgeranyl transferase type-2 subunit alpha, ... | Authors: | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | Deposit date: | 2008-07-14 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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3CPJ
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![BU of 3cpj by Molmil](/molmil-images/mine/3cpj) | Crystal structure of Ypt31 in complex with yeast Rab-GDI | Descriptor: | CHLORIDE ION, GTP-binding protein YPT31/YPT8, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Kravchenko, S, Ignatev, A, Goody, R.S, Rak, A, Pylypenko, O. | Deposit date: | 2008-03-31 | Release date: | 2008-05-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. J.Biol.Chem., 283, 2008
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3DSX
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![BU of 3dsx by Molmil](/molmil-images/mine/3dsx) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with di-prenylated peptide Ser-Cys(GG)-Ser-Cys(GG) derivated from Rab7 | Descriptor: | CALCIUM ION, GERAN-8-YL GERAN, Geranylgeranyl transferase type-2 subunit alpha, ... | Authors: | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | Deposit date: | 2008-07-14 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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3DSU
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![BU of 3dsu by Molmil](/molmil-images/mine/3dsu) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with farnesyl pyrophosphate | Descriptor: | CALCIUM ION, FARNESYL DIPHOSPHATE, Geranylgeranyl transferase type-2 subunit alpha, ... | Authors: | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | Deposit date: | 2008-07-14 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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3DSS
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![BU of 3dss by Molmil](/molmil-images/mine/3dss) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG) | Descriptor: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | Authors: | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | Deposit date: | 2008-07-14 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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3DSW
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![BU of 3dsw by Molmil](/molmil-images/mine/3dsw) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with mono-prenylated peptide Ser-Cys(GG)-Ser-Cys derivated from Rab7 | Descriptor: | CALCIUM ION, GERAN-8-YL GERAN, Geranylgeranyl transferase type-2 subunit alpha, ... | Authors: | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | Deposit date: | 2008-07-14 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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4HLQ
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![BU of 4hlq by Molmil](/molmil-images/mine/4hlq) | Crystal structure of human rab1b bound to GDP and BEF3 in complex with the GAP domain of TBC1D20 from homo sapiens | Descriptor: | BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Gazdag, E.M, Gavriljuk, K, Itzen, A, Koetting, C, Gerwert, K, Goody, R.S. | Deposit date: | 2012-10-17 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail. Proc.Natl.Acad.Sci.USA, 109, 2012
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4HL4
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![BU of 4hl4 by Molmil](/molmil-images/mine/4hl4) | Crystal structure of the human TBC1D20 RabGAP domain | Descriptor: | ACETATE ION, BERYLLIUM TRIFLUORIDE ION, TBC1 domain family member 20 | Authors: | Gazdag, E.M, Gavriljuk, K, Itzen, A, Koetting, C, Gerwert, K, Goody, R.S. | Deposit date: | 2012-10-16 | Release date: | 2013-01-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Catalytic mechanism of a mammalian Rab-RabGAP complex in atomic detail. Proc.Natl.Acad.Sci.USA, 109, 2012
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4I1M
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![BU of 4i1m by Molmil](/molmil-images/mine/4i1m) | Crystal structure of the Legionella pneumophila GAP domain of LepB | Descriptor: | DI(HYDROXYETHYL)ETHER, LepB | Authors: | Streller, A, Gazdag, E.M, Vetter, I.R, Goody, R.S, Itzen, A. | Deposit date: | 2012-11-21 | Release date: | 2013-01-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. Embo Rep., 14, 2013
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4I1O
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![BU of 4i1o by Molmil](/molmil-images/mine/4i1o) | Crystal structure of the Legionella pneumophila GAP domain of LepB in complex with Rab1b bound to GDP and BeF3 | Descriptor: | BERYLLIUM TRIFLUORIDE ION, DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Gazdag, E.M, Streller, A, Vetter, I.R, Goody, R.S, Itzen, A. | Deposit date: | 2012-11-21 | Release date: | 2013-01-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. Embo Rep., 14, 2013
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1GNP
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![BU of 1gnp by Molmil](/molmil-images/mine/1gnp) | X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP | Descriptor: | C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER | Authors: | Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. | Deposit date: | 1995-05-11 | Release date: | 1995-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
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1UKV
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![BU of 1ukv by Molmil](/molmil-images/mine/1ukv) | Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase | Descriptor: | GERAN-8-YL GERAN, GTP-binding protein YPT1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Rak, A, Pylypenko, O, Durek, T, Watzke, A, Kushnir, S, Brunsveld, L, Waldmann, H, Goody, R.S, Alexandrov, K. | Deposit date: | 2003-09-01 | Release date: | 2004-09-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase Science, 302, 2003
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1GNQ
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![BU of 1gnq by Molmil](/molmil-images/mine/1gnq) | X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP | Descriptor: | C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION | Authors: | Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. | Deposit date: | 1995-05-11 | Release date: | 1995-07-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
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1VG8
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![BU of 1vg8 by Molmil](/molmil-images/mine/1vg8) | GPPNHP-Bound Rab7 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7 | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | Deposit date: | 2004-04-23 | Release date: | 2004-07-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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1VG1
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![BU of 1vg1 by Molmil](/molmil-images/mine/1vg1) | GDP-Bound Rab7 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7 | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | Deposit date: | 2004-04-22 | Release date: | 2004-07-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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1VG0
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![BU of 1vg0 by Molmil](/molmil-images/mine/1vg0) | The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein | Descriptor: | CHLORIDE ION, GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | Deposit date: | 2004-04-22 | Release date: | 2004-07-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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5SZI
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![BU of 5szi by Molmil](/molmil-images/mine/5szi) | Structure of human Rab8a in complex with the bMERB domain of Mical-cL | Descriptor: | MAGNESIUM ION, MICAL C-terminal-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Mueller, M.P, Gazdag, E.M. | Deposit date: | 2016-08-14 | Release date: | 2016-08-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. Elife, 5, 2016
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5SZH
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![BU of 5szh by Molmil](/molmil-images/mine/5szh) | Structure of human Rab1b in complex with the bMERB domain of Mical-cL | Descriptor: | MAGNESIUM ION, MICAL C-terminal-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Goody, R.S, Mueller, M.P, Gazdag, E.M. | Deposit date: | 2016-08-14 | Release date: | 2016-08-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. Elife, 5, 2016
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