1JBG
 
 | | Crystal Structure of MtaN, the Bacillus subtilis Multidrug Transporter Activator, N-terminus | | Descriptor: | transcription activator of multidrug-efflux transporter genes mta | | Authors: | Godsey, M.H, Neyfakh, A.A, Brennan, R.G. | | Deposit date: | 2001-06-04 | | Release date: | 2001-11-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of MtaN, a global multidrug transporter gene activator.
J.Biol.Chem., 276, 2001
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2A2Z
 | | Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate | | Descriptor: | 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ... | | Authors: | Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A. | | Deposit date: | 2005-06-23 | | Release date: | 2006-01-17 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
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2A30
 | | Crystal structure of human deoxycytidine kinase in complex with deoxycytidine | | Descriptor: | 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase | | Authors: | Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A. | | Deposit date: | 2005-06-23 | | Release date: | 2006-01-17 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
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8V4S
 | | Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | | Deposit date: | 2023-11-29 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket.
Nat Commun, 15, 2024
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8TR5
 | | Cryo-EM structure of the rat P2X7 receptor in the apo closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket.
Nat Commun, 15, 2024
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8TRJ
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket.
Nat Commun, 15, 2024
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8TRB
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.36 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TR8
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.21 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TRA
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TR7
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977 | | Descriptor: | (1P)-1-(2,3-dichlorophenyl)-N-({2-[(pyridin-2-yl)oxy]phenyl}methyl)-1H-tetrazol-5-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TR6
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{[(5R)-5-(2,3-dichlorophenyl)tetrazolidin-1-yl]methyl}pyridine, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.18 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TRK
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4''-[methanetriyltris(4,1-phenyleneazanediyl)]tri(benzene-1-sulfonic acid), GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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