PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Discovery of MTA-cooperative PRMT5 Inhibitors from Co-factor directed DNA-Encoded Library Screens
Descriptor:	2-amino-3-methyl-N-(2-methylpropyl)-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}quinoline-6-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ...
Authors:	GhimireRijal, S, Mukund, S.
Deposit date:	2025-03-24
Release date:	2025-05-07
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	From DNA-Encoded Library Screening to AM-9747 - an MTA-Cooperative PRMT5 Inhibitor with Potent Oral in vivo Efficacy To Be Published

From DNA-Encoded Library Screening to AM-9747 - an MTA-Cooperative PRMT5 Inhibitor with Potent Oral in vivo Efficacy
Descriptor:	2-amino-3-methyl-N-[(1R)-1-(pyrimidin-2-yl)ethyl]-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}quinoline-6-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ...
Authors:	GhimireRijal, S, Mukund, S.
Deposit date:	2025-01-07
Release date:	2025-03-26
Last modified:	2025-04-02
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	From DNA-Encoded Library Screening to AM-9747 : An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy. J.Med.Chem., 68, 2025