9NWY

Discovery of MTA-cooperative PRMT5 Inhibitors from Co-factor directed DNA-Encoded Library Screens

This is a non-PDB format compatible entry.

Summary for 9NWY

• Entry DOI: 10.2210/pdb9nwy/pdb
• Related: 9MRE
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-amino-3-methyl-N-(2-methylpropyl)-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}quinoline-6-carboxamide, ... (5 entities in total)
• Functional Keywords: prmt5, mta-cooperative inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 111878.35

Authors

GhimireRijal, S.,Mukund, S. (deposition date: 2025-03-24, release date: 2025-05-07)

• Primary citation: Anderson, J.,Cowland, S.,Vestergaard, M.,Yang, Y.,Liu, S.,Fang, X.,Mukund, S.,GhimireRijal, S.,Carter, C.,Jasco, T.,Savary, I.,Hughes, P.E.,Gouliaev, A.,Belmontes, B.,Caenepeel, S.,Franch, T.,Glad, S.,Husemoen, B.,Nielson, S.J.; From DNA-Encoded Library Screening to AM-9747 - an MTA-Cooperative PRMT5 Inhibitor with Potent Oral in vivo Efficacy; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.1 Å)