8E8D
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![BU of 8e8d by Molmil](/molmil-images/mine/8e8d) | |
8E8C
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![BU of 8e8c by Molmil](/molmil-images/mine/8e8c) | |
8E89
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![BU of 8e89 by Molmil](/molmil-images/mine/8e89) | Human DNA polymerase eta-DNA-rU-ended primer-binary complex | Descriptor: | DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*U)-3') | Authors: | Chang, C, Gao, Y. | Deposit date: | 2022-08-25 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
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8E8H
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8E88
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![BU of 8e88 by Molmil](/molmil-images/mine/8e88) | Human DNA polymerase eta-DNA-rU-ended primer-dGMPNPP ternary mismatch complex with Mg2+ | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... | Authors: | Chang, C, Gao, Y. | Deposit date: | 2022-08-25 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
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8E85
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![BU of 8e85 by Molmil](/molmil-images/mine/8e85) | Human DNA polymerase eta-DNA-rG-ended primer-dGMPNPP ternary mismatch complex with Mn2+ | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*CP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... | Authors: | Chang, C, Gao, Y. | Deposit date: | 2022-08-25 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
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8E8K
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![BU of 8e8k by Molmil](/molmil-images/mine/8e8k) | Human DNA polymerase eta-DNA-rC-ended primer-dGMPNPP ternary mismatch complex with Mg2+ | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... | Authors: | Chang, C, Gao, Y. | Deposit date: | 2022-08-25 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
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8E8F
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8E8E
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8EFK
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![BU of 8efk by Molmil](/molmil-images/mine/8efk) | Structure of Lates calcarifer DNA polymerase theta polymerase domain with hairpin DNA | Descriptor: | 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(P*TP*TP*TP*TP*GP*GP*CP*TP*TP*TP*TP*GP*CP*CP*(2DA))-3'), Lates calcarifer DNA polymerase theta, ... | Authors: | Li, C, Zhu, H, Sun, J, Gao, Y. | Deposit date: | 2022-09-08 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
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8EF9
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![BU of 8ef9 by Molmil](/molmil-images/mine/8ef9) | Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*C)-3'), ... | Authors: | Li, C, Zhu, H, Sun, J, Gao, Y. | Deposit date: | 2022-09-08 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
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8EFC
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![BU of 8efc by Molmil](/molmil-images/mine/8efc) | Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*CP*TP*GP*TP*GP*AP*GP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*CP*CP*TP*CP*AP*CP*AP*G)-3'), ... | Authors: | Li, C, Zhu, H, Sun, J, Gao, Y. | Deposit date: | 2022-09-08 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
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2L26
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![BU of 2l26 by Molmil](/molmil-images/mine/2l26) | Rv0899 from Mycobacterium tuberculosis contains two separated domains | Descriptor: | Uncharacterized protein Rv0899/MT0922 | Authors: | Shi, C, Li, J, Gao, Y, Wu, K, Huang, H, Tian, C. | Deposit date: | 2010-08-12 | Release date: | 2011-08-17 | Last modified: | 2011-12-07 | Method: | SOLUTION NMR | Cite: | Structural Studies of Mycobacterium tuberculosis Rv0899 Reveal a Monomeric Membrane-Anchoring Protein with Two Separate Domains J.Mol.Biol., 2011
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4OQT
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![BU of 4oqt by Molmil](/molmil-images/mine/4oqt) | LINGO-1/Li81 Fab complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Li81 Fab, ... | Authors: | Pepinsky, R.B, Arndt, J.W, Quan, C, Gao, Y, Quintero-Monzon, O, Lee, X, Mi, S. | Deposit date: | 2014-02-10 | Release date: | 2014-05-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy. J.Pharmacol.Exp.Ther., 350, 2014
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7M7Q
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![BU of 7m7q by Molmil](/molmil-images/mine/7m7q) | Human DNA Pol eta S113A with dT-ended primer and dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M81
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![BU of 7m81 by Molmil](/molmil-images/mine/7m81) | Human DNA Pol eta with dA-ended primer and dATP: in crystallo reaction for 100 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M82
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![BU of 7m82 by Molmil](/molmil-images/mine/7m82) | Human DNA Pol eta with dA-ended primer and dATP: in crystallo reaction for 300 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7R
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![BU of 7m7r by Molmil](/molmil-images/mine/7m7r) | Human DNA Pol eta S113A with rA-ended primer and dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M87
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![BU of 7m87 by Molmil](/molmil-images/mine/7m87) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 230 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7N
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![BU of 7m7n by Molmil](/molmil-images/mine/7m7n) | Human DNA Pol eta with 2'-FA-ended primer and dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(AF5))-3'), DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M85
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![BU of 7m85 by Molmil](/molmil-images/mine/7m85) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 80 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7T
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![BU of 7m7t by Molmil](/molmil-images/mine/7m7t) | Human DNA Pol eta S113A with dT-ended primer and dATP: in crystallo reaction for 0 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M88
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![BU of 7m88 by Molmil](/molmil-images/mine/7m88) | Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 300 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7Y
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![BU of 7m7y by Molmil](/molmil-images/mine/7m7y) | Human DNA Pol eta with dA-ended primer and dATP: in crystallo reaction for 0 s | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-29 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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7M7S
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![BU of 7m7s by Molmil](/molmil-images/mine/7m7s) | Human DNA Pol eta S113A with dT-ended primer and 0.1 mM dAMPNPP | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Gregory, M.T, Gao, Y, Yang, W. | Deposit date: | 2021-03-28 | Release date: | 2021-06-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. Proc.Natl.Acad.Sci.USA, 118, 2021
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