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PDB: 15 件
7OUK
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BU of 7ouk by Molmil
BDM88855 inhibitor bound to the transmembrane domain of AcrB
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2021-06-12
公開日2021-12-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun, 13, 2022
7OUL
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BU of 7oul by Molmil
BDM88832 inhibitor bound to the transmembrane domain of AcrB-R971A
分子名称: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 1-(3-chloranyl-5-iodanyl-pyridin-2-yl)piperazine, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2021-06-12
公開日2021-12-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun, 13, 2022
7OUM
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BU of 7oum by Molmil
BDM88855 inhibitor bound to the transmembrane domain of AcrB-R971A
分子名称: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 3-chloranyl-2-piperazin-1-yl-quinoline, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2021-06-12
公開日2021-12-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Nat Commun, 13, 2022
6ZO8
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BU of 6zo8 by Molmil
Minocycline binding to the deep binding pocket of AcrB-G621P
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZO5
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BU of 6zo5 by Molmil
Fusidic acid binding to the TM1/TM2 groove of AcrB-G619P_G621P
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZO9
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BU of 6zo9 by Molmil
Binding of two rifabutins to the access pocket of AcrB-G621P T protomer
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZO6
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BU of 6zo6 by Molmil
Minocycline binding to the deep binding pocket of AcrB-G619P
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOB
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BU of 6zob by Molmil
3-Formylrifamycin SV binding to the access pocket of AcrB L protomer
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZO7
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BU of 6zo7 by Molmil
3-Formylrifamycin SV binding to the access pocket of AcrB-G619P L and T protomer
分子名称: (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOH
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BU of 6zoh by Molmil
3-Formylrifamycin SV binding to the access pocket of AcrB-G619P_G621P L and T protomers
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOF
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BU of 6zof by Molmil
Fusidic acid binding to the TM7/TM8 groove of AcrB-F380A T protomer
分子名称: DARPIN, DECANE, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOG
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BU of 6zog by Molmil
Minocycline binding to the deep binding pocket of AcrB-I38F_I671T
分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, 1,2-ETHANEDIOL, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOE
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BU of 6zoe by Molmil
AcrB-F563A symmetric T protomer
分子名称: 1,2-ETHANEDIOL, DARPIN, DECANE, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOA
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BU of 6zoa by Molmil
Partially induced AcrB T protomer and DDM binding to the TM8/PC2 pathway of AcrB L2 protomer
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DARPIN, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021
6ZOC
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BU of 6zoc by Molmil
Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer
分子名称: (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, DARPIN, ...
著者Tam, H.K, Foong, W.E, Pos, K.M.
登録日2020-07-07
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Allosteric drug transport mechanism of multidrug transporter AcrB.
Nat Commun, 12, 2021

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件を2024-07-03に公開中

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