4A0R
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![BU of 4a0r by Molmil](/molmil-images/mine/4a0r) | Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana bound to dethiobiotin (DTB). | Descriptor: | 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE, L(+)-TARTARIC ACID, ... | Authors: | Cobessi, D, Dumas, R, Pautre, V, Meinguet, C, Ferrer, J.L, Alban, C. | Deposit date: | 2011-09-12 | Release date: | 2012-06-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Biochemical and Structural Characterization of the Arabidopsis Bifunctional Enzyme Dethiobiotin Synthetase-Diaminopelargonic Acid Aminotransferase: Evidence for Substrate Channeling in Biotin Synthesis. Plant Cell, 24, 2012
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3KT5
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![BU of 3kt5 by Molmil](/molmil-images/mine/3kt5) | Crystal Structure of N88S mutant HIV-1 Protease | Descriptor: | Protease | Authors: | Bihani, S.C, Das, A, Prashar, V, Ferrer, J.L, Hosur, M.V. | Deposit date: | 2009-11-24 | Release date: | 2010-02-16 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S. Biochem.Biophys.Res.Commun., 389, 2009
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3KT2
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![BU of 3kt2 by Molmil](/molmil-images/mine/3kt2) | Crystal Structure of N88D mutant HIV-1 Protease | Descriptor: | Protease | Authors: | Bihani, S.C, Das, A, Prashar, V, Ferrer, J.L, Hosur, M.V. | Deposit date: | 2009-11-24 | Release date: | 2010-02-16 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S. Biochem.Biophys.Res.Commun., 389, 2009
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4Q5M
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![BU of 4q5m by Molmil](/molmil-images/mine/4q5m) | D30N tethered HIV-1 protease dimer/saquinavir complex | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, Protease | Authors: | Prashar, V, Bihani, S.C, Ferrer, J.L, Hosur, M.V. | Deposit date: | 2014-04-17 | Release date: | 2015-04-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir. Chem.Biol.Drug Des., 86, 2015
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2VWG
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![BU of 2vwg by Molmil](/molmil-images/mine/2vwg) | Haloferax mediterranei glucose dehydrogenase in complex with NADP, Zn and gluconolactone. | Descriptor: | D-glucono-1,5-lactone, GLUCOSE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Baker, P.J, Britton, K.L, Fisher, M, Esclapez, J, Pire, C, Bonete, M.J, Ferrer, J, Rice, D.W. | Deposit date: | 2008-06-24 | Release date: | 2009-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Active site dynamics in the zinc-dependent medium chain alcohol dehydrogenase superfamily. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2VWH
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![BU of 2vwh by Molmil](/molmil-images/mine/2vwh) | Haloferax mediterranei glucose dehydrogenase in complex with NADP, Zn and glucose. | Descriptor: | GLUCOSE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION, ... | Authors: | Baker, P.J, Britton, K.L, Fisher, M, Esclapez, J, Pire, C, Bonete, M.J, Ferrer, J, Rice, D.W. | Deposit date: | 2008-06-24 | Release date: | 2009-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Active site dynamics in the zinc-dependent medium chain alcohol dehydrogenase superfamily. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2VWP
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![BU of 2vwp by Molmil](/molmil-images/mine/2vwp) | Haloferax mediterranei glucose dehydrogenase in complex with NADPH and Zn. | Descriptor: | GLUCOSE DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION | Authors: | Baker, P.J, Britton, K.L, Fisher, M, Esclapez, J, Pire, C, Bonete, M.J, Ferrer, J, Rice, D.W. | Deposit date: | 2008-06-26 | Release date: | 2009-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Active site dynamics in the zinc-dependent medium chain alcohol dehydrogenase superfamily. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2VWQ
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![BU of 2vwq by Molmil](/molmil-images/mine/2vwq) | Haloferax mediterranei glucose dehydrogenase in complex with NADP and Zn. | Descriptor: | GLUCOSE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION | Authors: | Baker, P.J, Britton, K.L, Fisher, M, Esclapez, J, Pire, C, Bonete, M.J, Ferrer, J, Rice, D.W. | Deposit date: | 2008-06-26 | Release date: | 2009-01-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Active site dynamics in the zinc-dependent medium chain alcohol dehydrogenase superfamily. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2WHG
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![BU of 2whg by Molmil](/molmil-images/mine/2whg) | Crystal Structure of the Di-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa | Descriptor: | CITRATE ANION, VIM-4 METALLO-BETA-LACTAMASE, ZINC ION | Authors: | Lassaux, P, Traore, D.A.K, Galleni, M, Ferrer, J.L. | Deposit date: | 2009-05-05 | Release date: | 2010-05-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Biochemical and Structural Characterization of the Subclass B1 Metallo-{Beta}-Lactamase Vim-4. Antimicrob.Agents Chemother., 55, 2011
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2Q60
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![BU of 2q60 by Molmil](/molmil-images/mine/2q60) | Crystal structure of the ligand binding domain of polyandrocarpa misakiensis rxr in tetramer in absence of ligand | Descriptor: | Retinoid X receptor | Authors: | Borel, F, De Groot, A, Juillan-Binard, C, De Rosny, E, Laudet, V, Pebay-Peyroula, E, Fontecilla-Camps, J.-C, Ferrer, J.-L. | Deposit date: | 2007-06-04 | Release date: | 2008-05-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the ligand-binding domain of the retinoid X receptor from the ascidian polyandrocarpa misakiensis. Proteins, 74, 2008
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2WRS
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![BU of 2wrs by Molmil](/molmil-images/mine/2wrs) | Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa | Descriptor: | BETA-LACTAMASE VIM-4, CITRATE ANION, CITRIC ACID, ... | Authors: | Lassaux, P, Hamel, M, Gulea, M, Delbruck, H, Traore, D.A.K, Mercuri, P.S, Horsfall, L, Dehareng, D, Gaumont, A.-C, Frere, J.-M, Ferrer, J.-L, Hoffmann, K, Galleni, M, Bebrone, C. | Deposit date: | 2009-09-02 | Release date: | 2010-06-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-Beta-Lactamases. J.Med.Chem., 53, 2010
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1KNJ
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![BU of 1knj by Molmil](/molmil-images/mine/1knj) | Co-Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli Involved in Mevalonate-Independent Isoprenoid Biosynthesis, Complexed with CMP/MECDP/Mn2+ | Descriptor: | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Richard, S.B, Ferrer, J.L, Bowman, M.E, Lillo, A.M, Tetzlaff, C.N, Cane, D.E, Noel, J.P. | Deposit date: | 2001-12-18 | Release date: | 2002-06-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. J.Biol.Chem., 277, 2002
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2B5W
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![BU of 2b5w by Molmil](/molmil-images/mine/2b5w) | Crystal structure of D38C glucose dehydrogenase mutant from Haloferax mediterranei | Descriptor: | CITRATE ANION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | Authors: | Britton, K.L, Baker, P.J, Fisher, M, Ruzheinikov, S, Gilmour, D.J, Bonete, M.-J, Ferrer, J, Pire, C, Esclapez, J, Rice, D.W. | Deposit date: | 2005-09-29 | Release date: | 2006-04-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2B5V
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![BU of 2b5v by Molmil](/molmil-images/mine/2b5v) | Crystal structure of glucose dehydrogenase from Haloferax mediterranei | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, glucose dehydrogenase | Authors: | Britton, K.L, Baker, P.J, Fisher, M, Ruzheinikov, S, Gilmour, D.J, Bonete, M.-J, Ferrer, J, Pire, C, Esclapez, J, Rice, D.W. | Deposit date: | 2005-09-29 | Release date: | 2006-04-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1D6I
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![BU of 1d6i by Molmil](/molmil-images/mine/1d6i) | CHALCONE SYNTHASE (H303Q MUTANT) | Descriptor: | CHALCONE SYNTHASE, SULFATE ION | Authors: | Jez, J.M, Ferrer, J.L, Bowman, M.E, Dixon, R.A, Noel, J.P. | Deposit date: | 1999-10-13 | Release date: | 2000-02-03 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry, 39, 2000
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2BIS
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![BU of 2bis by Molmil](/molmil-images/mine/2bis) | Structure of glycogen synthase from Pyrococcus abyssi | Descriptor: | 1,4-DIETHYLENE DIOXIDE, GLGA GLYCOGEN SYNTHASE, GLYCEROL, ... | Authors: | Horcajada, C, Guinovart, J.J, Fita, I, Ferrer, J.C. | Deposit date: | 2005-01-25 | Release date: | 2005-11-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of an Archaeal Glycogen Synthase: Insights Into Oligomerisation and Substrate Binding of Eukaryotic Glycogen Synthases. J.Biol.Chem., 281, 2006
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1EE0
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![BU of 1ee0 by Molmil](/molmil-images/mine/1ee0) | 2-PYRONE SYNTHASE COMPLEXED WITH ACETOACETYL-COA | Descriptor: | 2-PYRONE SYNTHASE, ACETOACETYL-COENZYME A | Authors: | Jez, J.M, Austin, M.B, Ferrer, J, Bowmann, M.E, Schroeder, J, Noel, J.P. | Deposit date: | 2000-01-28 | Release date: | 2001-01-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural control of polyketide formation in plant-specific polyketide synthases. Chem.Biol., 7, 2000
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1D6F
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![BU of 1d6f by Molmil](/molmil-images/mine/1d6f) | CHALCONE SYNTHASE C164A MUTANT | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHALCONE SYNTHASE, SULFATE ION | Authors: | Jez, J.M, Ferrer, J.L, Bowman, M.E, Dixon, R.A, Noel, J.P. | Deposit date: | 1999-10-13 | Release date: | 2000-02-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry, 39, 2000
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1D6H
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![BU of 1d6h by Molmil](/molmil-images/mine/1d6h) | CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA) | Descriptor: | CHALCONE SYNTHASE, COENZYME A, SULFATE ION | Authors: | Jez, J.M, Ferrer, J.L, Bowman, M.E, Dixon, R.A, Noel, J.P. | Deposit date: | 1999-10-13 | Release date: | 2000-02-03 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry, 39, 2000
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1ZGJ
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![BU of 1zgj by Molmil](/molmil-images/mine/1zgj) | Crystal structure of isoflavanone 4'-O-methyltransferase complexed with (+)-pisatin | Descriptor: | (6AR,12AR)-3-(HYDROXYMETHYL)-6H-[1,3]DIOXOLO[5,6][1]BENZOFURO[3,2-C]CHROMEN-6A(12AH)-OL, Isoflavanone 4'-O-methyltransferase', S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Liu, C.-J, Deavours, B.E, Richard, S, Ferrer, J.-L, Dixon, R.A, Noel, J.P. | Deposit date: | 2005-04-21 | Release date: | 2006-08-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell, 18, 2006
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1ZG3
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![BU of 1zg3 by Molmil](/molmil-images/mine/1zg3) | Crystal structure of the isoflavanone 4'-O-methyltransferase complexed with SAH and 2,7,4'-trihydroxyisoflavanone | Descriptor: | (2S,3R)-2,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-4H-CHROMEN-4-ONE, S-ADENOSYL-L-HOMOCYSTEINE, isoflavanone 4'-O-methyltransferase | Authors: | Liu, C.-J, Deavours, B.E, Richard, S, Ferrer, J.-L, Dixon, R.A, Noel, J.P. | Deposit date: | 2005-04-20 | Release date: | 2006-08-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell, 18, 2006
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1ZHF
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![BU of 1zhf by Molmil](/molmil-images/mine/1zhf) | Crystal structure of selenomethionine substituted isoflavanone 4'-O-methyltransferase | Descriptor: | Isoflavanone 4'-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Liu, C.-J, Deavours, B.E, Richard, S, Ferrer, J.-L, Dixon, R.A, Noel, J.P. | Deposit date: | 2005-04-25 | Release date: | 2006-08-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell, 18, 2006
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1DDI
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![BU of 1ddi by Molmil](/molmil-images/mine/1ddi) | CRYSTAL STRUCTURE OF SIR-FP60 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT | Authors: | Gruez, A, Pignol, D, Zeghouf, M, Coves, J, Fontecave, M, Ferrer, J.L, Fontecilla-Camps, J.C. | Deposit date: | 1999-11-10 | Release date: | 2000-11-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module. J.Mol.Biol., 299, 2000
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1DDG
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![BU of 1ddg by Molmil](/molmil-images/mine/1ddg) | CRYSTAL STRUCTURE OF SIR-FP60 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, SULFITE REDUCTASE (NADPH) FLAVOPROTEIN ALPHA-COMPONENT | Authors: | Gruez, A, Pignol, D, Zeghouf, M, Coves, J, Fontecave, M, Ferrer, J.L, Fontecilla-Camps, J.C. | Deposit date: | 1999-11-10 | Release date: | 2000-11-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module. J.Mol.Biol., 299, 2000
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1U0U
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![BU of 1u0u by Molmil](/molmil-images/mine/1u0u) | An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: Pine stilbene synthase structure | Descriptor: | Dihydropinosylvin synthase | Authors: | Austin, M.B, Bowman, M.E, Ferrer, J.-L, Schroder, J, Noel, J.P. | Deposit date: | 2004-07-14 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases Chem.Biol., 11, 2004
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