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PDB: 50 件
6U44
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Crystal structure of Methanoperedens nitroreducens elongation factor 2 H595N bound to GMPPCP and magnesium (monoclinic crystal form)
分子名称: CHLORIDE ION, Elongation factor 2, MAGNESIUM ION, ...
著者Fenwick, M.K, Ealick, S.E.
登録日2019-08-22
公開日2020-03-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis of elongation factor 2 switching
Curr Res Struct Biol, 2, 2020
8FBQ
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BU of 8fbq by Molmil
Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b
分子名称: 1-[(3M)-3-{3-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]pyridin-2-yl}phenyl]piperazine, ACETATE ION, CHLORIDE ION, ...
著者Fenwick, M.K, Staker, B.L, Lovell, S.W, Phan, I.Q, Early, J, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-11-29
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.
Nat Commun, 14, 2023
6U45
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Crystal structure of Methanoperedens nitroreducens elongation factor 2 bound to GMPPCP and magnesium
分子名称: CHLORIDE ION, Elongation factor 2, MAGNESIUM ION, ...
著者Fenwick, M.K, Ealick, S.E.
登録日2019-08-22
公開日2020-03-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis of elongation factor 2 switching
Curr Res Struct Biol, 2, 2020
6U43
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Crystal structure of Methanoperedens nitroreducens elongation factor 2 H595N bound to GMPPCP and magnesium (triclinic crystal form)
分子名称: CHLORIDE ION, Elongation factor 2, MAGNESIUM ION, ...
著者Fenwick, M.K, Ealick, S.E.
登録日2019-08-22
公開日2020-03-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis of elongation factor 2 switching
Curr Res Struct Biol, 2, 2020
6Q2P
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BU of 6q2p by Molmil
Crystal structure of mouse viperin bound to cytidine triphosphate and S-adenosylhomocysteine
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E.
登録日2019-08-08
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.452 Å)
主引用文献Structural Basis of the Substrate Selectivity of Viperin.
Biochemistry, 59, 2020
6Q2Q
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Crystal structure of mouse viperin bound to uridine triphosphate and S-adenosylhomocysteine
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
著者Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E.
登録日2019-08-08
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.892 Å)
主引用文献Structural Basis of the Substrate Selectivity of Viperin.
Biochemistry, 59, 2020
4ESW
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BU of 4esw by Molmil
Crystal structure of C. albicans Thi5 H66G mutant
分子名称: CITRIC ACID, Pyrimidine biosynthesis enzyme THI13
著者Fenwick, M.K, Huang, S, Zhang, Y, Lai, R, Hazra, A, Rajashankar, K, Philmus, B, Kinsland, C, Sanders, J, Begley, T.P, Ealick, S.E.
登録日2012-04-23
公開日2012-09-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate.
J.Am.Chem.Soc., 134, 2012
6Q2E
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BU of 6q2e by Molmil
Crystal structure of Methanobrevibacter smithii Dph2 bound to 5'-methylthioadenosine
分子名称: 2-(3-amino-3-carboxypropyl)histidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
著者Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E.
登録日2019-08-07
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.768 Å)
主引用文献The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis.
Biochemistry, 58, 2019
6Q2D
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BU of 6q2d by Molmil
Crystal structure of Methanobrevibacter smithii Dph2 in complex with Methanobrevibacter smithii elongation factor 2
分子名称: 2-(3-amino-3-carboxypropyl)histidine synthase, Elongation factor 2, IRON/SULFUR CLUSTER
著者Fenwick, M.K, Dong, M, Lin, H, Ealick, S.E.
登録日2019-08-07
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis.
Biochemistry, 58, 2019
7RK3
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BU of 7rk3 by Molmil
Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
分子名称: 4'-diphospho pantetheine, ADP-ribosylation factor 6, Glycylpeptide N-tetradecanoyltransferase 1, ...
著者Fenwick, M.K, Lin, H.
登録日2021-07-21
公開日2022-07-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
To Be Published
7ROM
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BU of 7rom by Molmil
Crystal structure of Saccharomyces cerevisiae NADH-cytochrome b5 reductase 1 (Cbr1) fragment (residues 28-284) bound to FAD
分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, NADH-cytochrome b5 reductase 1, ...
著者Fenwick, M.K, Zhang, Y, Lin, H.
登録日2021-07-31
公開日2022-08-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of Saccharomyces cerevisiae NADH-cytochrome b5 reductase 1 (Cbr1) fragment (residues 28-284) bound to FAD
To Be Published
7SPQ
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BU of 7spq by Molmil
Crystal structure of Burkholderia glumae toxoflavin biosynthesis protein ToxD
分子名称: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ...
著者Fenwick, M.K, Philmus, B, Ealick, S.E.
登録日2021-11-03
公開日2023-05-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of Burkholderia glumae toxoflavin biosynthesis protein ToxD
To Be Published
3PKV
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BU of 3pkv by Molmil
Crystal Structure of Toxoflavin Lyase (TflA)
分子名称: Toxoflavin lyase (TflA)
著者Fenwick, M.K, Philmus, B, Begley, T.P, Ealick, S.E.
登録日2010-11-12
公開日2011-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad .
Biochemistry, 50, 2011
3PKW
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BU of 3pkw by Molmil
Crystal Structure of Toxoflavin Lyase (TflA) bound to Mn(II)
分子名称: MANGANESE (II) ION, Toxoflavin lyase (TflA)
著者Fenwick, M.K, Philmus, B, Begley, T.P, Ealick, S.E.
登録日2010-11-12
公開日2011-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad .
Biochemistry, 50, 2011
3PKX
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BU of 3pkx by Molmil
Crystal Structure of Toxoflavin Lyase (TflA) bound to Mn(II) and Toxoflavin
分子名称: 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione, MANGANESE (II) ION, Toxoflavin lyase (TflA)
著者Fenwick, M.K, Philmus, B, Begley, T.P, Ealick, S.E.
登録日2010-11-12
公開日2011-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad .
Biochemistry, 50, 2011
6BXN
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BU of 6bxn by Molmil
Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAM
分子名称: Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE
著者Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.079 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXO
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BU of 6bxo by Molmil
Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAH
分子名称: Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE
著者Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.655 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
6BXM
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BU of 6bxm by Molmil
Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAM/cleaved SAM
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALPHA-AMINOBUTYRIC ACID, Diphthamide biosynthesis enzyme Dph2, ...
著者Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E.
登録日2017-12-18
公開日2018-04-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Science, 359, 2018
5UFM
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BU of 5ufm by Molmil
Crystal structure of Burkholderia thailandensis 1,6-didemethyltoxoflavin-N1-methyltransferase with bound 1,6-didemethyltoxoflavin and S-adenosylhomocysteine
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Fenwick, M.K, Ealick, S.E, Almabruk, K.H, Begley, T.P, Philmus, B.
登録日2017-01-05
公開日2017-12-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
5UFN
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BU of 5ufn by Molmil
Crystal structure of Burkholderia thailandensis 1,6-didemethyltoxoflavin-N1-methyltransferase with bound S-adenosylhomocysteine
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Fenwick, M.K, Ealick, S.E, Almabruk, K.H, Begley, T.P, Philmus, B.
登録日2017-01-05
公開日2017-12-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
4S26
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BU of 4s26 by Molmil
Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide, S-adenosylhomocysteine, Fe4S4 cluster and Zn (monoclinic crystal form)
分子名称: 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
著者Fenwick, M.K, Mehta, A.P, Zhang, Y, Abdelwahed, S, Begley, T.P, Ealick, S.E.
登録日2015-01-19
公開日2015-04-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase.
Nat Commun, 6
5VSM
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BU of 5vsm by Molmil
Crystal structure of viperin with bound [4Fe-4S] cluster, 5'-deoxyadenosine, and L-methionine
分子名称: 5'-DEOXYADENOSINE, IRON/SULFUR CLUSTER, METHIONINE, ...
著者Fenwick, M.K, Li, Y, Cresswell, P, Modis, Y, Ealick, S.E.
登録日2017-05-11
公開日2017-06-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural studies of viperin, an antiviral radical SAM enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VSL
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BU of 5vsl by Molmil
Crystal structure of viperin with bound [4Fe-4S] cluster and S-adenosylhomocysteine (SAH)
分子名称: IRON/SULFUR CLUSTER, Radical S-adenosyl methionine domain-containing protein 2, S-ADENOSYL-L-HOMOCYSTEINE
著者Fenwick, M.K, Li, Y, Cresswell, P, Modis, Y, Ealick, S.E.
登録日2017-05-11
公開日2017-06-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.972 Å)
主引用文献Structural studies of viperin, an antiviral radical SAM enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4S29
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BU of 4s29 by Molmil
Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide and Fe
分子名称: 1,4-BUTANEDIOL, 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, FE (II) ION, ...
著者Fenwick, M.K, Mehta, A.P, Zhang, Y, Abdelwahed, S, Begley, T.P, Ealick, S.E.
登録日2015-01-19
公開日2015-04-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.382 Å)
主引用文献Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase.
Nat Commun, 6
4S25
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BU of 4s25 by Molmil
Crystal structure of Arabidopsis thaliana ThiC with bound imidazole ribonucleotide, S-adenosylhomocysteine, Fe4S4 cluster and Zn (trigonal crystal form)
分子名称: 1,4-BUTANEDIOL, 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, CHLORIDE ION, ...
著者Fenwick, M.K, Mehta, A.P, Zhang, Y, Abdelwahed, S, Begley, T.P, Ealick, S.E.
登録日2015-01-19
公開日2015-04-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase.
Nat Commun, 6

 

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