4GUS
| Crystal structure of LSD2-NPAC with H3 in space group P3221 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | 登録日 | 2012-08-29 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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4GUT
| Crystal structure of LSD2-NPAC | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1B, ... | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | 登録日 | 2012-08-29 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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4GU1
| Crystal structure of LSD2 | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, ... | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | 登録日 | 2012-08-29 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.939 Å) | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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4BK0
| Crystal structure of the KIX domain of human RECQL5 (domain-swapped dimer) | 分子名称: | ATP-DEPENDENT DNA HELICASE Q5, DI(HYDROXYETHYL)ETHER | 著者 | Kassube, S.A, Jinek, M, Fang, J, Tsutakawa, S, Nogales, E. | 登録日 | 2013-04-21 | 公開日 | 2013-06-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Mimicry in Transcription Regulation of Human RNA Polymerase II by the DNA Helicase Recql5 Nat.Struct.Mol.Biol., 20, 2013
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5C56
| Crystal structure of USP7/HAUSP in complex with ICP0 | 分子名称: | Ubiquitin E3 ligase ICP0, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Cheng, J, Li, Z, Gong, R, Fang, J, Yang, Y, Sun, C, Yang, H, Xu, Y. | 登録日 | 2015-06-19 | 公開日 | 2015-07-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.685 Å) | 主引用文献 | Molecular mechanism for the substrate recognition of USP7. Protein Cell, 6, 2015
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4YOC
| Crystal Structure of human DNMT1 and USP7/HAUSP complex | 分子名称: | DNA (cytosine-5)-methyltransferase 1, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION | 著者 | Cheng, J, Yang, H, Fang, J, Gong, R, Wang, P, Li, Z, Xu, Y. | 登録日 | 2015-03-11 | 公開日 | 2015-05-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.916 Å) | 主引用文献 | Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun, 6, 2015
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5LIK
| Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK181 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-14 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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5LIY
| Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK204 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-15 | 公開日 | 2016-10-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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5LIX
| Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK184 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-15 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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5LIU
| Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor IDD388 | 分子名称: | (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-15 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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4R43
| Crystal Structure Analysis of MTB PEPCK | 分子名称: | DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... | 著者 | Brynda, J, Dostal, J, Pichova, I, Snasel, J, Fanfrlik, J, Machova, I. | 登録日 | 2014-08-19 | 公開日 | 2015-04-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Plos One, 10, 2015
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4RCG
| Crystal Structure Analysis of MTB PEPCK without Mn+2 | 分子名称: | DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Brynda, J, Dostal, J, Snasel, J, Fanfrlik, J, Pichova, I, Machova, I. | 登録日 | 2014-09-16 | 公開日 | 2015-04-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Plos One, 10, 2015
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6MZC
| Human TFIID BC core | 分子名称: | Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 2, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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6MZM
| Human TFIID bound to promoter DNA and TFIIA | 分子名称: | SCP DNA (80-MER), TATA-box-binding protein, Transcription initiation factor IIA subunit 1, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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6MZD
| Human TFIID Lobe A canonical | 分子名称: | TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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5LIW
| Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK319 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | 登録日 | 2016-07-15 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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6MZL
| Human TFIID canonical state | 分子名称: | TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (23 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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5IYA
| Human core-PIC in the closed state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IY8
| Human holo-PIC in the initial transcribing state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IY6
| Human holo-PIC in the closed state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IY9
| Human holo-PIC in the initial transcribing state (no IIS) | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IYC
| Human core-PIC in the initial transcribing state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IVW
| Human core TFIIH bound to DNA within the PIC | 分子名称: | General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-21 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IY7
| Human holo-PIC in the open state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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1L1F
| Structure of human glutamate dehydrogenase-apo form | 分子名称: | Glutamate Dehydrogenase 1 | 著者 | Smith, T.J, Schmidt, T, Fang, J, Wu, J, Siuzdak, G, Stanley, C.A. | 登録日 | 2002-02-15 | 公開日 | 2002-03-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structure of apo human glutamate dehydrogenase details subunit communication and allostery. J.Mol.Biol., 318, 2002
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