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PDB: 10 results
4U89
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BU of 4u89 by Molmil
4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
Descriptor: COENZYME A, IMIDAZOLE, PHOSPHATE ION, ...
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2014-08-01
Release date:2015-08-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray structure of the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
to be published
5L84
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BU of 5l84 by Molmil
Structure of the H959F variant of the PpsC dehydratase domain from Mycobacterium tuberculosis
Descriptor: Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Gavalda, S, Mourey, L, Pedelacq, J.D.
Deposit date:2016-06-07
Release date:2017-08-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
6EZO
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BU of 6ezo by Molmil
Eukaryotic initiation factor EIF2B in complex with ISRIB
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Human eukaryotic initiation factor EIF2B epsilon subunits, Translation initiation factor eIF-2B subunit alpha, ...
Authors:Faille, A, Weis, F, Zyryanova, A, Warren, A.J, Ron, D.
Deposit date:2017-11-16
Release date:2018-03-28
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Science, 359, 2018
5I0K
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BU of 5i0k by Molmil
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases
Descriptor: CROTONYL COENZYME A, Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2016-02-04
Release date:2017-08-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
7OW7
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BU of 7ow7 by Molmil
EIF6-bound large subunit of the human ribosome
Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S rRNA, ...
Authors:Faille, A, Warren, A.J.
Deposit date:2021-06-16
Release date:2022-10-05
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure of human EIF6-bound large ribosomal subunit
To Be Published
8A3D
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BU of 8a3d by Molmil
Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Faille, A, Warren, A.J, Dent, K.C.
Deposit date:2022-06-08
Release date:2023-03-08
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (1.67 Å)
Cite:The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
4OOC
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BU of 4ooc by Molmil
Dehydratase domain of the polyketide PpsC from Mycobacterium tuberculosis
Descriptor: PHOSPHATE ION, Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2014-01-31
Release date:2015-08-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
4OKI
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BU of 4oki by Molmil
X-ray structure of the nucleotide-binding subdomain of the enoylreductase domain of PpsC from Mycobacterium tuberculosis
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2014-01-22
Release date:2015-08-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
7AHB
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BU of 7ahb by Molmil
Acyltransferase domain of the polyketide synthase PpsC of Mycobacterium tuberculosis
Descriptor: GLYCEROL, Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION, ...
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2020-09-24
Release date:2020-12-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
Acs Chem.Biol., 15, 2020
5NJI
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BU of 5nji by Molmil
Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA
Descriptor: Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate
Authors:Gavalda, S, Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2017-03-28
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017

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