2NX6
 
 | | Structure of NOWA cysteine rich domain 6 | | Descriptor: | Nematocyst outer wall antigen | | Authors: | Meier, S, Jensen, P.R, Adamczyk, P, Bachinger, H.P, Holstein, T.W, Engel, J, Ozbek, S, Grzesiek, S. | | Deposit date: | 2006-11-17 | | Release date: | 2007-10-02 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
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2NX7
 | | Structure of NOWA cysteine rich domain 8 | | Descriptor: | Nematocyst outer wall antigen | | Authors: | Meier, S, Jensen, P.R, Adamczyk, P, Bachinger, H.P, Holstein, T.W, Engel, J, Ozbek, S, Grzesiek, S. | | Deposit date: | 2006-11-17 | | Release date: | 2007-10-02 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
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5J9Z
 | | EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1a | | Descriptor: | (R)-1-(3-(4-amino-3-(1-methyl-1H-indol-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Epidermal growth factor receptor | | Authors: | Becker, C, Engel, J, Rauh, D. | | Deposit date: | 2016-04-11 | | Release date: | 2016-08-17 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew.Chem.Int.Ed.Engl., 55, 2016
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5J9Y
 | | EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b | | Descriptor: | (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Epidermal growth factor receptor | | Authors: | Becker, C, Engel, J, Rauh, D. | | Deposit date: | 2016-04-11 | | Release date: | 2016-08-17 | | Last modified: | 2016-09-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew.Chem.Int.Ed.Engl., 55, 2016
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1SRA
 | | STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN | | Descriptor: | CALCIUM ION, SPARC | | Authors: | Hohenester, E, Maurer, P, Hohenadl, C, Timpl, R, Jansonius, J.N, Engel, J. | | Deposit date: | 1995-08-21 | | Release date: | 1996-03-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of a novel extracellular Ca(2+)-binding module in BM-40.
Nat.Struct.Biol., 3, 1996
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3DMW
 | | Crystal structure of human type III collagen G982-G1023 containing C-terminal cystine knot | | Descriptor: | Collagen alpha-1(III) chain | | Authors: | Boudko, S.P, Engel, J, Okuyama, K, Mizuno, K, Bachinger, H.P, Schumacher, M.A. | | Deposit date: | 2008-07-01 | | Release date: | 2008-09-30 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries.
J.Biol.Chem., 283, 2008
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5D12
 | | Kinase domain of cSrc in complex with RL40 | | Descriptor: | N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Becker, C, Richters, A, Engel, J, Rauh, D. | | Deposit date: | 2015-08-03 | | Release date: | 2015-09-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J.Med.Chem., 58, 2015
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5D11
 | | Kinase domain of cSrc in complex with RL235 | | Descriptor: | GLYCEROL, N-[3-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Becker, C, Gruetter, C, Engel, J, Rauh, D. | | Deposit date: | 2015-08-03 | | Release date: | 2015-09-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J.Med.Chem., 58, 2015
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1AQ5
 | | HIGH-RESOLUTION SOLUTION NMR STRUCTURE OF THE TRIMERIC COILED-COIL DOMAIN OF CHICKEN CARTILAGE MATRIX PROTEIN, 20 STRUCTURES | | Descriptor: | CARTILAGE MATRIX PROTEIN | | Authors: | Dames, S.A, Wiltscheck, R, Kammerer, R.A, Engel, J, Alexandrescu, A.T. | | Deposit date: | 1997-08-07 | | Release date: | 1998-02-11 | | Last modified: | 2021-01-13 | | Method: | SOLUTION NMR | | Cite: | NMR structure of a parallel homotrimeric coiled coil.
Nat.Struct.Biol., 5, 1998
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3RGQ
 | | Crystal Structure of PTPMT1 in complex with PI(5)P | | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, Protein-tyrosine phosphatase mitochondrial 1 | | Authors: | Xiao, J, Engel, J.L. | | Deposit date: | 2011-04-08 | | Release date: | 2011-07-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RGO
 | | Crystal Structure of PTPMT1 | | Descriptor: | Protein-tyrosine phosphatase mitochondrial 1, SULFATE ION | | Authors: | Xiao, J, Engel, J.L. | | Deposit date: | 2011-04-08 | | Release date: | 2011-07-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.928 Å) | | Cite: | Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3SHQ
 | | Crystal Structure of UBLCP1 | | Descriptor: | MAGNESIUM ION, UBLCP1 | | Authors: | Xiao, J, Engel, J.L. | | Deposit date: | 2011-06-16 | | Release date: | 2011-10-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.
Proc.Natl.Acad.Sci.USA, 108, 2011
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1U9Q
 | | Crystal structure of cruzain bound to an alpha-ketoester | | Descriptor: | [1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER, cruzipain | | Authors: | Lange, M, Weston, S.G, Cheng, H, Culliane, M, Fiorey, M.M, Grisostomi, C, Hardy, L.W, Hartstough, D.S, Pallai, P.V, Tilton, R.F, Baldino, C.M, Brinen, L.S, Engel, J.C, Choe, Y, Price, M.S, Craik, C.S. | | Deposit date: | 2004-08-10 | | Release date: | 2005-03-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease
Bioorg.Med.Chem., 13, 2005
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3P0U
 | | Crystal Structure of the ligand binding domain of human testicular receptor 4 | | Descriptor: | Nuclear receptor subfamily 2 group C member 2 | | Authors: | Zhou, X.E, Suino-Powell, K.M, Xu, Y, Chan, C.-W, Kruse, S.W, Reynolds, R, Engel, J.D, Xu, H.E. | | Deposit date: | 2010-09-29 | | Release date: | 2010-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor.
J.Biol.Chem., 286, 2011
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1FF5
 | | STRUCTURE OF E-CADHERIN DOUBLE DOMAIN | | Descriptor: | CALCIUM ION, EPITHELIAL CADHERIN | | Authors: | Pertz, O, Bozic, D, Koch, A.W, Fauser, C, Brancaccio, A, Engel, J. | | Deposit date: | 2000-07-25 | | Release date: | 2000-08-23 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation.
EMBO J., 18, 1999
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2KER
 | | alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus | | Descriptor: | Alpha-amylase inhibitor Z-2685 | | Authors: | Rehm, S, Han, S, Hassani, I, Sokocevic, A, Jonker, H.R.A, Engels, J.W, Schwalbe, H. | | Deposit date: | 2009-02-02 | | Release date: | 2009-02-17 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158
Chembiochem, 10, 2009
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1HHW
 | | Solution structure of LNA1:RNA hybrid | | Descriptor: | 5- D(*CP*TP*GP*AP*+TLNP*AP*TP*GP*C) -3, 5- R(*GP*CP*AP*UP*AP*UP*CP*AP*G) -3 | | Authors: | Petersen, M, Bondensgaard, K, Wengel, J, Jacobsen, J.P. | | Deposit date: | 2000-12-29 | | Release date: | 2002-05-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Locked Nucleic Acid (Lna) Recognition of RNA: NMR Solution Structures of Lna:RNA Hybrids
J.Am.Chem.Soc., 124, 2002
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1HHX
 | | Solution structure of LNA3:RNA hybrid | | Descriptor: | 5- D(*CP*+TP*GP*AP*+TP*AP*+TP*GP*C) -3, 5- R(*GP*CP*AP*UP*AP*UP*CP*AP*G) -3 | | Authors: | Petersen, M, Bondensgaard, K, Wengel, J, Jacobsen, J.P. | | Deposit date: | 2000-12-29 | | Release date: | 2002-05-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Locked Nucleic Acid (Lna) Recognition of RNA: NMR Solution Structures of Lna:RNA Hybrids
J.Am.Chem.Soc., 124, 2002
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214D
 | | THE SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A SINGLE 2'-O-METHYL-BETA-D-ARAT | | Descriptor: | DNA (5'-D(*CP*GP*CP*AP*TP*AP*TP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*AP*(T41)P*AP*TP*GP*CP*G)-3') | | Authors: | Gotfredsen, C.H, Spielmann, H.P, Wengel, J, Jacobsen, J.P. | | Deposit date: | 1995-07-07 | | Release date: | 1995-10-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of a DNA duplex containing a single 2'-O-methyl-beta-D-araT: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.
Bioconjug.Chem., 7, 1996
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1I5W
 | | A-DNA DECAMER GCGTA(TLN)ACGC | | Descriptor: | 5'-D(*GP*CP*GP*TP*AP*(TLN)P*AP*CP*GP*C)-3' | | Authors: | Egli, M, Minasov, G, Teplova, M, Kumar, R, Wengel, J. | | Deposit date: | 2001-03-01 | | Release date: | 2001-04-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer
J.Chem.Soc.,Chem.Commun., 2001
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1HG9
 | | Solution structure of DNA:RNA hybrid | | Descriptor: | 5- D(*CP*TP*GP*AP*TP*AP*TP*GP*C) -3, 5- R(*GP*CP*AP*UP*AP*UP*CP*AP*G) -3 | | Authors: | Petersen, M, Bondensgaard, K, Wengel, J, Jacobsen, J.P. | | Deposit date: | 2000-12-13 | | Release date: | 2002-01-02 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity.
Chemistry, 6, 2000
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1H0Q
 | | NMR solution structure of a fully modified locked nucleic acid (LNA) hybridized to RNA | | Descriptor: | 5-D(*(LKC)P*(TLN)P*(LCG)P*(LCA)P*(TLN)P*(LCA)P* (TLN)P*(LCG)P*(LCC))-3, 5-R(*GP*CP*AP*UP*AP*UP*CP*AP*G)-3 | | Authors: | Rasmussen, J, Petersen, M, Nielsen, K.E, Kumar, R, Wengel, J, Jacobsen, J.P. | | Deposit date: | 2002-06-27 | | Release date: | 2003-07-17 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR Studies of Fully Modified Locked Nucleic Acid (Lna) Hybrids: Solution Structure of an Lna:RNA Hybrid and Characterization of an Lna:RNA Hybrid
Bioconjug.Chem., 15, 2004
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1GV6
 | | Solution structure of alfa-L-LNA:DNA duplex | | Descriptor: | 5- D(*CP*(ATL)P*GP*CP*(ATL)P*(ATL)P*CP*(ATL)P* GP*C) -3, 5- D(*GP*CP*AP*GP*AP*AP*GP*CP*AP*G) -3 | | Authors: | Nielsen, K.M.E, Petersen, M, Haakansson, A.E, Wengel, J, Jacobsen, J.P. | | Deposit date: | 2002-02-06 | | Release date: | 2002-07-05 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Alfa-L-Lna (Alfa-L-Ribo Configured Locked Nucleic Acid) Recognition of DNA: An NMR Spectroscopic Study
Chemistry, 8, 2002
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1EI4
 | | B-DNA DODECAMER CGCGAAT(TLC)CGCG WITH INCORPORATED [3.3.0]BICYCLO-ARABINO-THYMINE-5'-PHOSPHATE | | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*(TLC)P*(TLC)P*CP*GP*CP*G)-3'), MAGNESIUM ION, SPERMINE | | Authors: | Minasov, G, Teplova, M, Nielsen, P, Wengel, J, Egli, M. | | Deposit date: | 2000-02-24 | | Release date: | 2000-03-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA.
Biochemistry, 39, 2000
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