8PAE
 
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8PAG
 | | Crystal structure of the ectodomain of Norway rat pestivirus E2 glycoprotein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Aitkenhead, H, Stuart, D.I, EL Omari, K. | | Deposit date: | 2023-06-07 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural comparison of typical and atypical E2 pestivirus glycoproteins.
Structure, 32, 2024
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8PYV
 | | Structure of Human PS-1 GSH-analog complex, solved at wavelength 2.755 A | | Descriptor: | L-gamma-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-L-cysteinylglycine, PALMITIC ACID, Prostaglandin E synthase | | Authors: | Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Wagner, A, Vogeley, L, Brown, D.G. | | Deposit date: | 2023-07-26 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
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8PZ4
 | | Structure of alginate transporter, AlgE, solved at wavelength 2.755 A | | Descriptor: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ... | | Authors: | Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Wagner, A, Vogeley, L, Brown, D.G. | | Deposit date: | 2023-07-26 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
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8PZ5
 | | Structure of ThcOx, solved at wavelength 3.099 A | | Descriptor: | FLAVIN MONONUCLEOTIDE, SagB-type dehydrogenase domain protein | | Authors: | Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Wagner, A. | | Deposit date: | 2023-07-27 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
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8PYZ
 | | Structure of Ompk36GD from Klebsiella pneumonia, solved at wavelength 4.13 A | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE, OmpK36 | | Authors: | Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Kwong, H, Beis, K, Wagner, A. | | Deposit date: | 2023-07-26 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
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7OOT
 | | X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element | | Descriptor: | DNA (5'-D(P*AP*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), DNA (5'-D(P*TP*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor 4, ... | | Authors: | Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J. | | Deposit date: | 2021-05-28 | | Release date: | 2022-06-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element
To Be Published
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7PGN
 | | HHP-C in complex with glycosaminoglycan mimic SOS | | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | | Deposit date: | 2021-08-14 | | Release date: | 2021-12-15 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
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7PGK
 | | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | | Deposit date: | 2021-08-14 | | Release date: | 2021-12-15 | | Last modified: | 2021-12-22 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
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7PGL
 | | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | | Descriptor: | Hedgehog-interacting protein | | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | | Deposit date: | 2021-08-14 | | Release date: | 2021-12-15 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
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7PGM
 | | HHIP-C in complex with heparin | | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein | | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | | Deposit date: | 2021-08-14 | | Release date: | 2021-12-15 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
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8CJV
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2Y7I
 | | Structural basis for high arginine specificity in Salmonella typhimurium periplasmic binding protein STM4351. | | Descriptor: | ACETATE ION, ARGININE, GLYCEROL, ... | | Authors: | Stamp, A.L, Owen, P, El Omari, K, Lockyer, M, Lamb, H.K, Charles, I.G, Hawkins, A.R, Stammers, D.K. | | Deposit date: | 2011-01-31 | | Release date: | 2011-05-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystallographic and Microcalorimetric Analyses Reveal the Structural Basis for High Arginine Specificity in the Salmonella Enterica Serovar Typhimurium Periplasmic Binding Protein Stm4351.
Proteins, 79, 2011
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7QU8
 | | ADGRG3/GPR97 Extracellular Region | | Descriptor: | Adhesion G protein-coupled receptor G3 | | Authors: | Zheng-Gerard, C, Chu, T.Y, El Omari, K, Lin, H.H, Seiradake, E. | | Deposit date: | 2022-01-17 | | Release date: | 2022-09-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.37 Å) | | Cite: | GPR97-mediated PAR2 transactivation via a mPR3-associated macromolecular complex induces inflammatory activation of human neutrophils
Nat Commun, 2022
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6HJ5
 | | Crystal structure of Whitewater Arroyo virus GP1 glycoprotein at pH 5.6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pre-glycoprotein polyprotein GP complex | | Authors: | Pryce, R, Ng, W.M, Zeltina, A, Watanabe, Y, El Omari, K, Wagner, A, Bowden, T.A. | | Deposit date: | 2018-08-31 | | Release date: | 2018-10-10 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1.
J. Virol., 93, 2019
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6HJC
 | | Crystal structure of Loei River virus GP1 glycoprotein at pH 8.0 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Pre-glycoprotein polyprotein GP complex | | Authors: | Pryce, R, Ng, W.M, Zeltina, A, Watanabe, Y, El Omari, K, Wagner, A, Bowden, T.A. | | Deposit date: | 2018-09-03 | | Release date: | 2018-10-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1.
J. Virol., 93, 2019
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2XF4
 | | Crystal structure of Salmonella enterica serovar typhimurium YcbL | | Descriptor: | HYDROXYACYLGLUTATHIONE HYDROLASE, TETRAETHYLENE GLYCOL, ZINC ION | | Authors: | Stamp, A, Owen, P, El Omari, K, Nichols, C, Lockyer, M, Lamb, H, Charles, I, Hawkins, A.R, Stammers, D.K. | | Deposit date: | 2010-05-20 | | Release date: | 2010-07-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and Functional Characterization of Salmonella Enterica Serovar Typhimurium Ycbl: An Unusual Type II Glyoxalase
Protein Sci., 19, 2010
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8CI3
 | | Structure of bovine CD46 ectodomain (SCR 1-2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Aitkenhead, H, David I Stuart, D.I, El Omari, K. | | Deposit date: | 2023-02-08 | | Release date: | 2023-07-12 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Structure of Bovine CD46 Ectodomain.
Viruses, 15, 2023
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6HJ6
 | | Crystal structure of Loei River virus GP1 glycoprotein at pH 5.0 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Pre-glycoprotein polyprotein GP complex | | Authors: | Pryce, R, Ng, W.M, Zeltina, A, Watanabe, Y, El Omari, K, Wagner, A, Bowden, T.A. | | Deposit date: | 2018-08-31 | | Release date: | 2018-10-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1.
J. Virol., 93, 2019
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6HJ4
 | | Crystal structure of Whitewater Arroyo virus GP1 glycoprotein at pH 7.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Pre-glycoprotein polyprotein GP complex | | Authors: | Pryce, R, Ng, W.M, Zeltina, A, Watanabe, Y, El Omari, K, Wagner, A, Bowden, T.A. | | Deposit date: | 2018-08-31 | | Release date: | 2018-10-10 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1.
J. Virol., 93, 2019
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8CKM
 | | Semaphorin-5A TSR 3-4 domains | | Descriptor: | Semaphorin-5A | | Authors: | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-28 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structure and function of Semaphorin-5A glycosaminoglycan interactions.
Nat Commun, 15, 2024
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8CKG
 | | Semaphorin-5A TSR 3-4 domains in complex with sulfate | | Descriptor: | SULFATE ION, Semaphorin-5A, alpha-D-mannopyranose | | Authors: | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-28 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (1.714 Å) | | Cite: | Structure and function of Semaphorin-5A glycosaminoglycan interactions.
Nat Commun, 15, 2024
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8CKK
 | | Semaphorin-5A TSR 3-4 domains in complex with nitrate | | Descriptor: | NITRATE ION, Semaphorin-5A, alpha-D-mannopyranose | | Authors: | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-28 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Structure and function of Semaphorin-5A glycosaminoglycan interactions.
Nat Commun, 15, 2024
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8CKL
 | | Semaphorin-5A TSR 3-4 domains in complex with sucrose octasulfate (SOS) | | Descriptor: | 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-2)-1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose, Semaphorin-5A, alpha-D-mannopyranose | | Authors: | Nagy, G.N, Duman, R, Harlos, K, El Omari, K, Wagner, A, Jones, E.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2024-02-28 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Structure and function of Semaphorin-5A glycosaminoglycan interactions.
Nat Commun, 15, 2024
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8BWI
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 2 | | Descriptor: | Twisted gastrulation protein homolog 1 | | Authors: | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | Deposit date: | 2022-12-06 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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