6YBH
| Deoxyribonucleoside Kinase | Descriptor: | Deoxynucleoside kinase, GLYCEROL, Pyrrolo-dC, ... | Authors: | Allouche-Arnon, H, Bar-Shir, A, Dym, O. | Deposit date: | 2020-03-17 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression. Nat.Biotechnol., 40, 2022
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5HPZ
| type II water soluble Chl binding proteins | Descriptor: | 13'2-hydroxyl-Chlorophyll a, Water-soluble chlorophyll protein | Authors: | Bednarczyk, D, Dym, O, Prabahard, V, Noy, D. | Deposit date: | 2016-01-21 | Release date: | 2016-05-04 | Last modified: | 2019-05-29 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation. Angew.Chem.Int.Ed.Engl., 55, 2016
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2NVB
| Contribution of Pro275 to the Thermostability of the Alcohol Dehydrogenases (ADHs) | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADP-dependent alcohol dehydrogenase, ZINC ION | Authors: | Goihberg, E, Tel-Or, S, Peretz, M, Frolow, F, Dym, O, Burstein, Y, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2006-11-12 | Release date: | 2007-11-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution Proteins, 72, 2008
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6Q61
| Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | Descriptor: | Kunitz-type conkunitzin-S1, SULFATE ION | Authors: | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | Deposit date: | 2018-12-10 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Pore-modulating toxins exploit inherent slow inactivation to block K+channels. Proc.Natl.Acad.Sci.USA, 116, 2019
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6Q6C
| Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | Descriptor: | 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ... | Authors: | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | Deposit date: | 2018-12-10 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Pore-modulating toxins exploit inherent slow inactivation to block K+channels. Proc.Natl.Acad.Sci.USA, 116, 2019
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2OUI
| D275P mutant of alcohol dehydrogenase from protozoa Entamoeba histolytica | Descriptor: | 1,2-ETHANEDIOL, CACODYLATE ION, CHLORIDE ION, ... | Authors: | Frolow, F, Shimon, L, Burstein, Y, Goihberg, E, Peretz, M, Dym, O. | Deposit date: | 2007-02-11 | Release date: | 2008-02-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution. Proteins, 72, 2008
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6HAM
| Adenylate kinase | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE | Authors: | Kantaev, R, Inbal, R, Goldenzweig, A, Barak, Y, Dym, O, Peleg, Y, Albek, S, Fleishman, S.J, Haran, G. | Deposit date: | 2018-08-08 | Release date: | 2019-08-28 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Manipulating the Folding Landscape of a Multidomain Protein. J.Phys.Chem.B, 122, 2018
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6HAP
| Adenylate kinase | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE | Authors: | Kantaev, R, Inbal, R, Goldenzweig, A, Barak, Y, Dym, O, Peleg, Y, Albek, S, Fleishman, S.J, Haran, G. | Deposit date: | 2018-08-08 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Manipulating the Folding Landscape of a Multidomain Protein. J.Phys.Chem.B, 122, 2018
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6ZOI
| A lid blocking mechanism of a cone snail toxin revealed at the atomic level | Descriptor: | Conknunitzin-C3 mutante | Authors: | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | Deposit date: | 2020-07-07 | Release date: | 2021-07-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | A lid blocking mechanism of a cone snail toxin revealed at the atomic level To Be Published
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7BH9
| SARS-CoV-2 RBD-62 in complex with ACE2 peptidase domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Elad, N, Dym, O, Zahradnik, J, Schreiber, G. | Deposit date: | 2021-01-11 | Release date: | 2021-02-17 | Last modified: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution. Nat Microbiol, 6, 2021
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4OUU
| anti-MT1-MMP monoclonal antibody | Descriptor: | anti_MT1-MMP Heavy chain, anti_MT1-MMP light chain | Authors: | Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Koziol, A, Cuniasse, P, Dive, V, Arroyo, A.G, Irit, S, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2014-02-19 | Release date: | 2014-12-17 | Last modified: | 2015-01-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure, 23, 2015
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6YHT
| A lid blocking mechanism of a cone snail toxin revealed at the atomic level | Descriptor: | CITRIC ACID, Conk-C1, SULFATE ION | Authors: | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | Deposit date: | 2020-03-31 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide. J.Mol.Biol., 433, 2021
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6YHY
| A lid blocking mechanism of a cone snail toxin revealed at the atomic level | Descriptor: | Conk-S1 | Authors: | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | Deposit date: | 2020-03-31 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide. J.Mol.Biol., 433, 2021
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2B5R
| 1B Lactamase / B Lactamase Inhibitor | Descriptor: | Beta-lactamase TEM, Beta-lactamase inhibitory protein | Authors: | Rahat, O, Albeck, S, Meged, R, Dym, O, Screiber, G, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2005-09-29 | Release date: | 2006-04-11 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture. J.Mol.Biol., 102, 2006
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3IIV
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3IIP
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5NPO
| Promiscuous Protein Self-Assembly as a Function of Protein Stability | Descriptor: | Beta-lactamase, Beta-lactamase TEM, MAGNESIUM ION | Authors: | Cohen-Khait, R, Dym, O, Hamer-Rogotner, S, Schreiber, G. | Deposit date: | 2017-04-18 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Promiscuous Protein Binding as a Function of Protein Stability. Structure, 25, 2017
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3IIO
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2RKX
| The 3D structure of chain D, cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase | Descriptor: | Cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase | Authors: | Tawfik, D, Khersonsky, O, Albeck, S, Dym, O, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2007-10-18 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Kemp elimination catalysts by computational enzyme design. Nature, 453, 2008
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5C2M
| The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | Descriptor: | Predicted protein | Authors: | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | Deposit date: | 2015-06-16 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
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5C2N
| The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta propeller | Authors: | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | Deposit date: | 2015-06-16 | Release date: | 2016-01-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
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2YAT
| Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex | Descriptor: | ESTRADIOL-PYRIDINIUM TETRAACETIC ACID, ESTROGEN RECEPTOR, EUROPIUM ION, ... | Authors: | Li, M.J, Greenblatt, H.M, Dym, O, Albeck, S, Degani, H, Sussman, J.L. | Deposit date: | 2011-02-24 | Release date: | 2011-06-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators. J.Med.Chem., 54, 2011
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4QXU
| Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody | Descriptor: | Matrix metalloproteinase-14, SULFATE ION, anti_MT1-MMP Heavy chain, ... | Authors: | Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Moreno, v, Cuiniasse, P, Dive, V, Arroyo, A.G, Sagi, I, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2014-07-22 | Release date: | 2014-12-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure, 23, 2015
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2B83
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2F1O
| Crystal Structure of NQO1 with Dicoumarol | Descriptor: | BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1 | Authors: | Shaul, Y, Asher, G, Dym, O, Tsvetkov, P, Adler, J, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2005-11-15 | Release date: | 2006-05-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. Biochemistry, 45, 2006
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