6YBH
 
 | | Deoxyribonucleoside Kinase | | 分子名称: | Deoxynucleoside kinase, GLYCEROL, Pyrrolo-dC, ... | | 著者 | Allouche-Arnon, H, Bar-Shir, A, Dym, O. | | 登録日 | 2020-03-17 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.
Nat.Biotechnol., 40, 2022
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5HPZ
 | | type II water soluble Chl binding proteins | | 分子名称: | 13'2-hydroxyl-Chlorophyll a, Water-soluble chlorophyll protein | | 著者 | Bednarczyk, D, Dym, O, Prabahard, V, Noy, D. | | 登録日 | 2016-01-21 | | 公開日 | 2016-05-04 | | 最終更新日 | 2019-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.
Angew.Chem.Int.Ed.Engl., 55, 2016
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2NVB
 | | Contribution of Pro275 to the Thermostability of the Alcohol Dehydrogenases (ADHs) | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADP-dependent alcohol dehydrogenase, ZINC ION | | 著者 | Goihberg, E, Tel-Or, S, Peretz, M, Frolow, F, Dym, O, Burstein, Y, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2006-11-12 | | 公開日 | 2007-11-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution
Proteins, 72, 2008
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6Q61
 | | Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | | 分子名称: | Kunitz-type conkunitzin-S1, SULFATE ION | | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | | 登録日 | 2018-12-10 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6Q6C
 | | Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | | 分子名称: | 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ... | | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | | 登録日 | 2018-12-10 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
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2OUI
 | | D275P mutant of alcohol dehydrogenase from protozoa Entamoeba histolytica | | 分子名称: | 1,2-ETHANEDIOL, CACODYLATE ION, CHLORIDE ION, ... | | 著者 | Frolow, F, Shimon, L, Burstein, Y, Goihberg, E, Peretz, M, Dym, O. | | 登録日 | 2007-02-11 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution.
Proteins, 72, 2008
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6HAM
 | | Adenylate kinase | | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE | | 著者 | Kantaev, R, Inbal, R, Goldenzweig, A, Barak, Y, Dym, O, Peleg, Y, Albek, S, Fleishman, S.J, Haran, G. | | 登録日 | 2018-08-08 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Manipulating the Folding Landscape of a Multidomain Protein.
J.Phys.Chem.B, 122, 2018
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6HAP
 | | Adenylate kinase | | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE | | 著者 | Kantaev, R, Inbal, R, Goldenzweig, A, Barak, Y, Dym, O, Peleg, Y, Albek, S, Fleishman, S.J, Haran, G. | | 登録日 | 2018-08-08 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Manipulating the Folding Landscape of a Multidomain Protein.
J.Phys.Chem.B, 122, 2018
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6ZOI
 | | A lid blocking mechanism of a cone snail toxin revealed at the atomic level | | 分子名称: | Conknunitzin-C3 mutante | | 著者 | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | | 登録日 | 2020-07-07 | | 公開日 | 2021-07-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | A lid blocking mechanism of a cone snail toxin revealed at the atomic level
To Be Published
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7BH9
 | | SARS-CoV-2 RBD-62 in complex with ACE2 peptidase domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | | 著者 | Elad, N, Dym, O, Zahradnik, J, Schreiber, G. | | 登録日 | 2021-01-11 | | 公開日 | 2021-02-17 | | 最終更新日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.
Nat Microbiol, 6, 2021
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4OUU
 | | anti-MT1-MMP monoclonal antibody | | 分子名称: | anti_MT1-MMP Heavy chain, anti_MT1-MMP light chain | | 著者 | Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Koziol, A, Cuniasse, P, Dive, V, Arroyo, A.G, Irit, S, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2014-02-19 | | 公開日 | 2014-12-17 | | 最終更新日 | 2015-01-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
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6YHT
 | | A lid blocking mechanism of a cone snail toxin revealed at the atomic level | | 分子名称: | CITRIC ACID, Conk-C1, SULFATE ION | | 著者 | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | | 登録日 | 2020-03-31 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide.
J.Mol.Biol., 433, 2021
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6YHY
 | | A lid blocking mechanism of a cone snail toxin revealed at the atomic level | | 分子名称: | Conk-S1 | | 著者 | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | | 登録日 | 2020-03-31 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide.
J.Mol.Biol., 433, 2021
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2B5R
 | | 1B Lactamase / B Lactamase Inhibitor | | 分子名称: | Beta-lactamase TEM, Beta-lactamase inhibitory protein | | 著者 | Rahat, O, Albeck, S, Meged, R, Dym, O, Screiber, G, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2005-09-29 | | 公開日 | 2006-04-11 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture.
J.Mol.Biol., 102, 2006
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3IIV
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3IIP
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5NPO
 | | Promiscuous Protein Self-Assembly as a Function of Protein Stability | | 分子名称: | Beta-lactamase, Beta-lactamase TEM, MAGNESIUM ION | | 著者 | Cohen-Khait, R, Dym, O, Hamer-Rogotner, S, Schreiber, G. | | 登録日 | 2017-04-18 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Promiscuous Protein Binding as a Function of Protein Stability.
Structure, 25, 2017
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3IIO
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2RKX
 | | The 3D structure of chain D, cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase | | 分子名称: | Cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase | | 著者 | Tawfik, D, Khersonsky, O, Albeck, S, Dym, O, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2007-10-18 | | 公開日 | 2008-03-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Kemp elimination catalysts by computational enzyme design.
Nature, 453, 2008
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5C2M
 | | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | | 分子名称: | Predicted protein | | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | | 登録日 | 2015-06-16 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
Cell, 164, 2016
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5C2N
 | | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta propeller | | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | | 登録日 | 2015-06-16 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
Cell, 164, 2016
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2YAT
 | | Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex | | 分子名称: | ESTRADIOL-PYRIDINIUM TETRAACETIC ACID, ESTROGEN RECEPTOR, EUROPIUM ION, ... | | 著者 | Li, M.J, Greenblatt, H.M, Dym, O, Albeck, S, Degani, H, Sussman, J.L. | | 登録日 | 2011-02-24 | | 公開日 | 2011-06-01 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.
J.Med.Chem., 54, 2011
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4QXU
 | | Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody | | 分子名称: | Matrix metalloproteinase-14, SULFATE ION, anti_MT1-MMP Heavy chain, ... | | 著者 | Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Moreno, v, Cuiniasse, P, Dive, V, Arroyo, A.G, Sagi, I, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2014-07-22 | | 公開日 | 2014-12-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
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2B83
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2F1O
 | | Crystal Structure of NQO1 with Dicoumarol | | 分子名称: | BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1 | | 著者 | Shaul, Y, Asher, G, Dym, O, Tsvetkov, P, Adler, J, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2005-11-15 | | 公開日 | 2006-05-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.
Biochemistry, 45, 2006
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