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PDB: 15 件
8U0Q
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Co-crystal structure of optimized analog TDI-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series
分子名称: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Dementiev, A.A, Michino, M, Vendome, J, Ginn, J, Bryk, R, Olland, A.
登録日2023-08-29
公開日2024-01-03
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
Acs Bio Med Chem Au, 3, 2023
3H5C
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X-Ray Structure of Protein Z-Protein Z Inhibitor Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein Z-dependent protease inhibitor, Vitamin K-dependent protein Z, ...
著者Dementiev, A.A, Huang, X, Olson, S.T, Gettins, P.G.W.
登録日2009-04-21
公開日2010-04-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.26 Å)
主引用文献Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.
J.Biol.Chem., 285, 2010
6W0P
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Putative kojibiose phosphorylase from human microbiome
分子名称: Kojibiose phosphorylase
著者Dementiev, A, Osipiuk, J, Endres, M, Wakatsuki, S, Hess, M, Joachimiak, A.
登録日2020-03-02
公開日2020-03-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Putative kojibiose phosphorylase from human microbiome
to be published
6B77
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Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XII, GLYCEROL, ...
著者Dementiev, A.A, Silva, A, Yee, C, Flavin, M.T, Partridge, J.R.
登録日2017-10-03
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv, 2, 2018
6MHM
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Crystal structure of human acid ceramidase in covalent complex with carmofur
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Dementiev, A, Joachimiak, A, Doan, N.
登録日2018-09-18
公開日2019-01-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.743 Å)
主引用文献Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
J. Med. Chem., 62, 2019
2D26
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BU of 2d26 by Molmil
Active site distortion is sufficient for proteinase inhibit second crystal structure of covalent serpin-proteinase complex
分子名称: Alpha-1-antitrypsin, Elastase-1
著者Dementiev, A, Dobo, J, Gettins, P.G.
登録日2005-09-03
公開日2005-11-29
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Active Site Distortion Is Sufficient for Proteinase Inhibition by Serpins: Structure of the covalent complex of alpha 1-proteinase inhibitor with porcine pancreatic elastase
J.Biol.Chem., 281, 2006
6B74
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Structures of the two-chain human plasma Factor XIIa co-crystallized with potent inhibitors
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, Coagulation factor XII, ...
著者Dementiev, A.A, Partridge, J.R.
登録日2017-10-03
公開日2018-03-21
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.323 Å)
主引用文献Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv, 2, 2018
6CB0
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Crystal Structure of the FAK FERM domain
分子名称: Focal adhesion kinase 1
著者Dementiev, A, Marlowe, T.
登録日2018-02-01
公開日2019-02-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site.
BMC Mol Cell Biol, 20, 2019
1OO8
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CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION
分子名称: Alpha-1-antitrypsin precursor
著者Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G.
登録日2003-03-03
公開日2003-08-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
J.Biol.Chem., 278, 2003
1OPH
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NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN
分子名称: Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor
著者Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G.
登録日2003-03-05
公開日2003-08-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
J.Biol.Chem., 278, 2003
1SR5
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ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE
分子名称: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-2,3,6-tri-O-methyl-alpha-D-xylo-hexopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3R,4S,5S,6S)-6-(dihydroxymethyl)-3,4-dimethoxytetrahydro-2H-pyran-2,5-diol-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3R,4S,5S,6R)-6-(dihydroxymethyl)-3,4-dimethoxytetrahydro-2H-pyran-2,5-diol-(1-4)-1,5-anhydro-3-O-methyl-2,6-di-O-sulfo-D-glucitol, ...
著者Dementiev, A, Petitou, M, Gettins, P.G.
登録日2004-03-22
公開日2004-08-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.
Nat.Struct.Mol.Biol., 11, 2004
8GHX
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Crystal Structure of CelD Cellulase from the Anaerobic Fungus Piromyces finnis
分子名称: 1,2-ETHANEDIOL, Cellulase CelD
著者Dementieve, A, Kim, Y, Jedrzejczak, R, Michalska, K, Joachimiak, A.
登録日2023-03-13
公開日2023-05-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Structure and enzymatic characterization of CelD endoglucanase from the anaerobic fungus Piromyces finnis.
Appl.Microbiol.Biotechnol., 107, 2023
8GHY
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Crystal Structure of the E154D mutant CelD Cellulase from the Anaerobic Fungus Piromyces finnis in the complex with cellotriose.
分子名称: Cellulase CelD, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose
著者Dementieve, A, Kim, Y, Jedrzejczak, R, Michalska, K, Joachimiak, A.
登録日2023-03-13
公開日2023-05-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and enzymatic characterization of CelD endoglucanase from the anaerobic fungus Piromyces finnis.
Appl.Microbiol.Biotechnol., 107, 2023
7T85
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Crystal Structure of the N-terminal Domain of the Phosphate Acetyltransferase from Escherichia coli
分子名称: 1,2-ETHANEDIOL, ACETIC ACID, Phosphate acetyltransferase, ...
著者Kim, Y, Dementiev, A, Welk, L, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-12-15
公開日2021-12-29
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the N-terminal Domain of the Phosphate Acetyltransferase from Escherichia coli
To Be Published
7T88
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Crystal Structure of the C-terminal Domain of the Phosphate Acetyltransferase from Escherichia coli
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, IODIDE ION, ...
著者Kim, Y, Dementiev, A, Welk, L, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-12-15
公開日2021-12-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of c from Escherichia coli
To Be Published

226707

件を2024-10-30に公開中

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