4JFX
| Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide | 分子名称: | Fab heavy chain, Fab light chain, Phosphopeptide, ... | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | 登録日 | 2013-02-28 | 公開日 | 2013-09-25 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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4JG0
| Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide | 分子名称: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | 登録日 | 2013-02-28 | 公開日 | 2013-08-28 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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4JFZ
| Structure of phosphoserine (pSAb) scaffold bound to pSer peptide | 分子名称: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | 登録日 | 2013-02-28 | 公開日 | 2013-08-28 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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4JG1
| Structure of phosphoserine/threonine (pSTAb) scaffold bound to pThr peptide | 分子名称: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | 登録日 | 2013-02-28 | 公開日 | 2013-08-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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4JFY
| Apo structure of phosphotyrosine (pYAb) scaffold | 分子名称: | Fab heavy chain, Fab light chain, TETRAETHYLENE GLYCOL | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | 登録日 | 2013-02-28 | 公開日 | 2013-08-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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6MJH
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6MQU
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6MQ2
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6MPW
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6NV1
| Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor | 分子名称: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, ... | 著者 | Thomaston, J.L, Liu, L, DeGrado, W.F. | 登録日 | 2019-02-04 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59, 2020
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6O3N
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6OUG
| Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct | 分子名称: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, Matrix protein 2 | 著者 | Thomaston, J.L, Liu, L, DeGrado, W.F. | 登録日 | 2019-05-04 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59, 2020
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5V2Q
| CaV beta2a subunit: CaV1.2 AID-CEN complex | 分子名称: | 1,3-bis(bromomethyl)benzene, CHLORIDE ION, Voltage-dependent L-type calcium channel subunit alpha-1C, ... | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | 登録日 | 2017-03-06 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci, 8, 2017
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5V2O
| De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | 分子名称: | 1,3,5-BENZENETRICARBOXYLIC ACID, GLYCEROL, NONAETHYLENE GLYCOL, ... | 著者 | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | 登録日 | 2017-03-06 | 公開日 | 2017-10-04 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UGK
| Zinc-Binding Structure of a Catalytic Amyloid from Solid-State NMR Spectroscopy | 分子名称: | ILE-HIS-VAL-HIS-LEU-GLN-ILE, ZINC ION | 著者 | Lee, M, Wang, T, Makhlynets, O.V, Wu, Y, Polizzi, N, Wu, H, Gosavi, P.M, Korendovych, I.V, DeGrado, W.F, Hong, M. | 登録日 | 2017-01-09 | 公開日 | 2017-05-31 | 最終更新日 | 2024-05-15 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UM1
| XFEL structure of influenza A M2 wild type TM domain at intermediate pH in the lipidic cubic phase at room temperature | 分子名称: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | 著者 | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | 登録日 | 2017-01-25 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | 主引用文献 | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V2P
| CaV beta2a subunit: CaV1.2 AID-CAP complex | 分子名称: | 1,3-bis(bromomethyl)benzene, NICKEL (II) ION, PENTAETHYLENE GLYCOL, ... | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | 登録日 | 2017-03-06 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci, 8, 2017
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5V2G
| De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | 分子名称: | 1,3,5-tris(bromomethyl)benzene, 20-mer Peptide | 著者 | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | 登録日 | 2017-03-03 | 公開日 | 2017-09-27 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TTC
| XFEL structure of influenza A M2 wild type TM domain at high pH in the lipidic cubic phase at room temperature | 分子名称: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | 著者 | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | 登録日 | 2016-11-02 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6ANF
| Design of a short thermo-stable alpha-helix embedded in a macrocycle | 分子名称: | 3,3'-dimethyl-1,1'-biphenyl, Capped-strapped peptide | 著者 | Wu, H, Acharyya, A, Wu, Y, Liu, L, Jo, H, Gai, F, DeGrado, W.F. | 登録日 | 2017-08-13 | 公開日 | 2018-02-21 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Design of a Short Thermally Stable alpha-Helix Embedded in a Macrocycle. Chembiochem, 19, 2018
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6BKL
| Influenza A M2 transmembrane domain bound to rimantadine | 分子名称: | (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, Matrix protein 2, RIMANTADINE | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-08 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BKK
| Influenza A M2 transmembrane domain bound to amantadine | 分子名称: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, CHLORIDE ION, Matrix protein 2 | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-08 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BMZ
| Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor | 分子名称: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, CHLORIDE ION, Matrix protein 2 | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-15 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.634 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6D02
| Cross-alpha Amyloid-like Structure alphaAmL, 2nd form | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CARBONATE ION, PHOSPHATE ION, ... | 著者 | Zhang, S.-Q, Liu, L, Degrado, W.F. | 登録日 | 2018-04-10 | 公開日 | 2019-02-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Designed peptides that assemble into cross-alpha amyloid-like structures. Nat. Chem. Biol., 14, 2018
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6BOC
| Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation | 分子名称: | (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, CHLORIDE ION, Matrix protein 2, ... | 著者 | Thomaston, J.L, DeGrado, W.F. | 登録日 | 2017-11-19 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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