7JRQ
| Crystallographically Characterized De Novo Designed Mn-Diphenylporphyrin Binding Protein | Descriptor: | CHLORIDE ION, GLYCEROL, MPP1, ... | Authors: | Mann, S.I, DeGrado, W.F. | Deposit date: | 2020-08-12 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species. J.Am.Chem.Soc., 143, 2021
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8TNB
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8TNC
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8TN1
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8TN6
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8TND
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7UDV
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7UDZ
| Designed pentameric proton channel LQLL | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed pentameric proton channel LQLL | Authors: | Kratochvil, H.T, Thomaston, J.L, Mravic, M, Nicoludis, J.M, Liu, L, DeGrado, W.F. | Deposit date: | 2022-03-20 | Release date: | 2022-04-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Transient water wires mediate selective proton transport in designed channel proteins. Nat.Chem., 15, 2023
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7UDY
| Designed pentameric channel QLLL | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Designed channel QLLL | Authors: | Kratochvil, H.T, Thomaston, J.L, Liu, L, DeGrado, W.F. | Deposit date: | 2022-03-20 | Release date: | 2022-04-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Transient water wires mediate selective proton transport in designed channel proteins. Nat.Chem., 15, 2023
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6YB1
| Crystal structure of an antiparallel octameric transmembrane coiled coil K2-CCTM-VbIc | Descriptor: | GLYCINE, K2-CCTM-VbIc, NONAETHYLENE GLYCOL | Authors: | Kratochvil, H.T, Liu, L, Scott, A.J, Woolfson, D.N, DeGrado, W.F. | Deposit date: | 2020-03-15 | Release date: | 2021-04-07 | Last modified: | 2021-07-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Constructing ion channels from water-soluble alpha-helical barrels. Nat.Chem., 13, 2021
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1QP6
| SOLUTION STRUCTURE OF ALPHA2D | Descriptor: | PROTEIN (ALPHA2D) | Authors: | Hill, R.B, DeGrado, W.F. | Deposit date: | 1999-06-01 | Release date: | 1999-06-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of Alpha2D, A Nativelike De Novo Designed Protein J.Am.Chem.Soc., 120, 1998
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3V86
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3UUG
| Crystal structure of the periplasmic sugar binding protein ChvE | Descriptor: | Multiple sugar-binding periplasmic receptor ChvE, beta-D-glucopyranuronic acid | Authors: | Hu, X, Zhao, J, Binns, A, Degrado, W. | Deposit date: | 2011-11-28 | Release date: | 2012-11-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals. Proc.Natl.Acad.Sci.USA, 110, 2013
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3URM
| Crystal structure of the periplasmic sugar binding protein ChvE | Descriptor: | Multiple sugar-binding periplasmic receptor ChvE, beta-D-galactopyranose | Authors: | Hu, X, Zhao, J, Binns, A, Degrado, W. | Deposit date: | 2011-11-22 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals. Proc.Natl.Acad.Sci.USA, 110, 2013
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6O3N
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1YOD
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1Y47
| Structural studies of designed alpha-helical hairpins | Descriptor: | CADMIUM ION, dueferri (DF2) | Authors: | Lahr, S.J, Engel, D.E, Stayrook, S.E, Maglio, O, North, B, Geremia, S, Lombardi, A, DeGrado, W.F. | Deposit date: | 2004-11-30 | Release date: | 2005-03-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Analysis and design of turns in alpha-helical hairpins J.Mol.Biol., 346, 2005
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6OUG
| Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct | Descriptor: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, Matrix protein 2 | Authors: | Thomaston, J.L, Liu, L, DeGrado, W.F. | Deposit date: | 2019-05-04 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59, 2020
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5UGK
| Zinc-Binding Structure of a Catalytic Amyloid from Solid-State NMR Spectroscopy | Descriptor: | ILE-HIS-VAL-HIS-LEU-GLN-ILE, ZINC ION | Authors: | Lee, M, Wang, T, Makhlynets, O.V, Wu, Y, Polizzi, N, Wu, H, Gosavi, P.M, Korendovych, I.V, DeGrado, W.F, Hong, M. | Deposit date: | 2017-01-09 | Release date: | 2017-05-31 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2KZ2
| Calmodulin, C-terminal domain, F92E mutant | Descriptor: | CALCIUM ION, Calmodulin | Authors: | Korendovych, I, Kulp, D, Wu, Y, Cheng, H, Roder, H, DeGrado, W. | Deposit date: | 2010-06-10 | Release date: | 2011-04-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Design of a switchable eliminase. Proc.Natl.Acad.Sci.USA, 108, 2011
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6Z0L
| Het-N2 - De novo designed three-helix heterodimer with Cysteine at the N2 position of the alpha-helix | Descriptor: | CADMIUM ION, Cys-N2 Strand, Positive Strand, ... | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. | Deposit date: | 2020-05-09 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
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6Z0M
| Het-Ncap - De novo designed three-helix heterodimer with Cysteine at the Ncap position of the alpha-helix | Descriptor: | Cys-Ncap strand, Positive Strand, SULFATE ION, ... | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. | Deposit date: | 2020-05-09 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
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1AL1
| CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN | Descriptor: | ALPHA HELIX PEPTIDE: ELLKKLLEELKG, SULFATE ION | Authors: | Hill, C.P, Anderson, D.H, Wesson, L, Degrado, W.F, Eisenberg, D. | Deposit date: | 1990-07-02 | Release date: | 1991-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of alpha 1: implications for protein design. Science, 249, 1990
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4JG0
| Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide | Descriptor: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | Authors: | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | Deposit date: | 2013-02-28 | Release date: | 2013-08-28 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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4JFX
| Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide | Descriptor: | Fab heavy chain, Fab light chain, Phosphopeptide, ... | Authors: | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | Deposit date: | 2013-02-28 | Release date: | 2013-09-25 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Nature-inspired design of motif-specific antibody scaffolds. Nat.Biotechnol., 31, 2013
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