6RCU
 
 | | PfRH5 bound to monoclonal antibodies R5.004 and R5.016 | | 分子名称: | R5.004 heavy chain, R5.004 light chain, R5.016 heavy chain, ... | | 著者 | Alanine, D.W.G, Draper, S.J, Higgins, M.K. | | 登録日 | 2019-04-11 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (4.005 Å) | | 主引用文献 | Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Cell, 178, 2019
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6T8U
 | | Complement factor B in complex with 5-Bromo-3-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-7-methyl-1H-indol-4-amine | | 分子名称: | 5-bromanyl-3-chloranyl-~{N}-(1~{H}-imidazol-2-yl)-7-methyl-1~{H}-indol-4-amine, Complement factor B, SULFATE ION | | 著者 | Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Mac Sweeney, A, Wiesmann, C, Adams, C, Liao, S.-M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Serrano-Wu, M, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, De Erkenez, A, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M. | | 登録日 | 2019-10-25 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
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1S9E
 | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385 | | 分子名称: | 4-[4-AMINO-6-(2,6-DICHLORO-PHENOXY)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE, POL polyprotein [Contains: Reverse transcriptase], POL polyprotein [Contains:Reverse transcriptase] | | 著者 | Das, K, Clark Jr, A.D, Ludovici, D.W, Kukla, M.J, Decorte, B, Lewi, P.J, Hughes, S.H, Janssen, P.A, Arnold, E. | | 登録日 | 2004-02-04 | | 公開日 | 2004-05-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants.
J.Med.Chem., 47, 2004
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5J4G
 | | Crystal structure of the C-terminally His6-tagged HP0902, an uncharacterized protein from Helicobacter pylori 26695 | | 分子名称: | Uncharacterized protein | | 著者 | Sim, D.W, Lee, W.C, Kim, H.Y, Kim, J.H, Won, H.S. | | 登録日 | 2016-04-01 | | 公開日 | 2017-02-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural identification of the lipopolysaccharide-binding capability of a cupin-family protein from Helicobacter pylori
FEBS Lett., 590, 2016
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1S9G
 | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394. | | 分子名称: | 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE, POL polyprotein [Contains: Reverse transcriptase] | | 著者 | Das, K, Clark Jr, A.D, Ludovici, D.W, Kukla, M.J, Decorte, B, Lewi, P.J, Hughes, S.H, Janssen, P.A, Arnold, E. | | 登録日 | 2004-02-04 | | 公開日 | 2004-05-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants.
J.Med.Chem., 47, 2004
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5JH7
 | | Tubulin-Eribulin complex | | 分子名称: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Doodhi, H, Prota, A.E, Rodriguez-Garcia, R, Xiao, H, Custar, D.W, Bargsten, K, Katrukha, E.A, Hilbert, M, Hua, S, Jiang, K, Grigoriev, I, Yang, C.-P.H, Cox, D, Band Horwitz, S, Kapitein, L.C, Akhmanova, A, Steinmetz, M.O. | | 登録日 | 2016-04-20 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.
Curr.Biol., 26, 2016
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1L0I
 | | Crystal structure of butyryl-ACP I62M mutant | | 分子名称: | Acyl carrier protein, CACODYLATE ION, SODIUM ION, ... | | 著者 | Roujeinikova, A, Baldock, C, Simon, W.J, Gilroy, J, Baker, P.J, Stuitje, A.R, Rice, D.W, Slabas, A.R, Rafferty, J.B. | | 登録日 | 2002-02-11 | | 公開日 | 2003-02-11 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | X-ray Crystallographic Studies on Butyryl-ACP Reveal Flexibility of the Structure around a Putative Acyl Chain Binding Site
Structure, 10, 2002
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1NJ9
 | | Cocaine hydrolytic antibody 15A10 | | 分子名称: | SODIUM ION, immunoglobulin heavy chain, immunoglobulin variable chain | | 著者 | Larsen, N.A, de Prada, P, Deng, S.X, Zhu, X, Landry, D.W, Wilson, I.A. | | 登録日 | 2002-12-30 | | 公開日 | 2004-02-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10.
Biochemistry, 43, 2004
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5JZL
 | | The Structure of Monomeric Ultra Stable Green Fluorescent Protein | | 分子名称: | CHLORIDE ION, Green fluorescent protein, SODIUM ION | | 著者 | Gunn, N.J, Yong, K.J, Scott, D.J, Griffin, M.D.W. | | 登録日 | 2016-05-17 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY.
Sci Rep, 8, 2018
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1L0H
 | | CRYSTAL STRUCTURE OF BUTYRYL-ACP FROM E.COLI | | 分子名称: | ACYL CARRIER PROTEIN, ZINC ION | | 著者 | Roujeinikova, A, Baldock, C, Simon, W.J, Gilroy, J, Baker, P.J, Stuitje, A.R, Rice, D.W, Slabas, A.R, Rafferty, J.B. | | 登録日 | 2002-02-11 | | 公開日 | 2003-02-11 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site
Structure, 10, 2002
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6T8V
 | | Complement factor B in complex with (S)-5,7-Dimethyl-4-((2-phenylpiperidin-1-yl)methyl)-1H-indole | | 分子名称: | 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ... | | 著者 | Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Mac Sweeney, A, Wiesmann, C, Adams, C, Mainolfi, N, Liao, S.-M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Serrano-Wu, M, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, De Erkenez, A, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Wiesmann, C, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M. | | 登録日 | 2019-10-25 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
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5LQ7
 | | Salmonella effector SpvD - G161 variant | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Przydacz, M, Grabe, G.J, Holden, D.W, Hare, S.A. | | 登録日 | 2016-08-16 | | 公開日 | 2016-11-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.
J. Biol. Chem., 291, 2016
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1SAY
 | | L-ALANINE DEHYDROGENASE COMPLEXED WITH PYRUVATE | | 分子名称: | L-ALANINE DEHYDROGENASE, PYRUVIC ACID | | 著者 | Baker, P.J, Sawa, Y, Shibata, H, Sedelnikova, S.E, Rice, D.W. | | 登録日 | 1998-06-05 | | 公開日 | 1999-06-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.
Nat.Struct.Biol., 5, 1998
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1SUL
 | | Crystal Structure of the apo-YsxC | | 分子名称: | GTP-binding protein YsxC | | 著者 | Ruzheinikov, S.N, Das, K.S, Sedelnikova, S.E, Baker, P.J, Artymiuk, P.J, Garcia-Lara, J, Foster, S.J, Rice, D.W. | | 登録日 | 2004-03-26 | | 公開日 | 2004-05-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Analysis of the Open and Closed Conformations of the GTP-binding Protein YsxC from Bacillus subtilis.
J.Mol.Biol., 339, 2004
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1LWJ
 | | CRYSTAL STRUCTURE OF T. MARITIMA 4-ALPHA-GLUCANOTRANSFERASE/ACARBOSE COMPLEX | | 分子名称: | 4-ALPHA-GLUCANOTRANSFERASE, CALCIUM ION, MODIFIED ACARBOSE PENTASACCHARIDE | | 著者 | Roujeinikova, A, Raasch, C, Sedelnikova, S, Liebl, W, Rice, D.W. | | 登録日 | 2002-05-31 | | 公開日 | 2002-08-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA 4-ALPHA-GLUCANOTRANSFERASE AND ITS ACARBOSE COMPLEX:
IMPLICATIONS FOR SUBSTRATE SPECIFICITY AND CATALYSIS
J.Mol.Biol., 321, 2002
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1MIE
 | | Crystal Structure Of The Fab Fragment of Esterolytic Antibody MS5-393 | | 分子名称: | IMMUNOGLOBULIN MS5-393 | | 著者 | Ruzheinikov, S.N, Muranova, T.A, Sedelnikova, S.E, Partridge, L.J, Blackburn, G.M, Murray, I.A, Kakinuma, H, Takashi, N, Shimazaki, K, Sun, J, Nishi, Y, Rice, D.W. | | 登録日 | 2002-08-23 | | 公開日 | 2003-09-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
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1ROP
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1SVI
 | | Crystal Structure of the GTP-binding protein YsxC complexed with GDP | | 分子名称: | GTP-binding protein YSXC, GUANOSINE-5'-DIPHOSPHATE | | 著者 | Ruzheinikov, S.N, Das, S.K, Sedelnikova, S.E, Baker, P.J, Artymiuk, P.J, Garcia-Lara, J, Foster, S.J, Rice, D.W. | | 登録日 | 2004-03-29 | | 公開日 | 2004-05-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Analysis of the Open and Closed Conformations of the GTP-binding Protein YsxC from Bacillus subtilis.
J.Mol.Biol., 339, 2004
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1PER
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1SVW
 | | Crystal Structure of YsxC complexed with GMPPNP | | 分子名称: | GTP-binding protein YsxC, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Ruzheinikov, S.N, Das, S.K, Sedelnikova, S.E, Baker, P.J, Artymiuk, P.J, Garcia-Lara, J, Foster, S.J, Rice, D.W. | | 登録日 | 2004-03-30 | | 公開日 | 2004-05-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Analysis of the Open and Closed Conformations of the GTP-binding Protein YsxC from Bacillus subtilis.
J.Mol.Biol., 339, 2004
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1RLA
 | | THREE-DIMENSIONAL STRUCTURE OF RAT LIVER ARGINASE, THE BINUCLEAR MANGANESE METALLOENZYME OF THE UREA CYCLE | | 分子名称: | ARGINASE, MANGANESE (II) ION | | 著者 | Kanyo, Z, Scolnick, L, Ash, D, Christianson, D.W. | | 登録日 | 1996-08-15 | | 公開日 | 1997-10-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of a unique binuclear manganese cluster in arginase.
Nature, 383, 1996
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1P8P
 | | Structural and Functional Importance of First-Shell Metal Ligands in the Binuclear Manganese Cluster of Arginase I. | | 分子名称: | Arginase 1, MANGANESE (II) ION | | 著者 | Cama, E, Emig, F.A, Ash, D.E, Christianson, D.W. | | 登録日 | 2003-05-07 | | 公開日 | 2003-06-17 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and functional importance of first-shell metal ligands in the binuclear
manganese cluster of arginase I
Biochemistry, 42, 2003
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1PJC
 | | L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (L-ALANINE DEHYDROGENASE) | | 著者 | Baker, P.J, Sawa, Y, Shibata, H, Sedelnikova, S.E, Rice, D.W. | | 登録日 | 1998-06-05 | | 公開日 | 1999-07-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.
Nat.Struct.Biol., 5, 1998
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1PJB
 | | L-ALANINE DEHYDROGENASE | | 分子名称: | L-ALANINE DEHYDROGENASE | | 著者 | Baker, P.J, Sawa, Y, Shibata, H, Sedelnikova, S.E, Rice, D.W. | | 登録日 | 1998-06-05 | | 公開日 | 1999-06-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.
Nat.Struct.Biol., 5, 1998
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1PS1
 | | PENTALENENE SYNTHASE | | 分子名称: | PENTALENENE SYNTHASE, TRIMETHYL LEAD ION | | 著者 | Lesburg, C.A, Christianson, D.W. | | 登録日 | 1997-03-23 | | 公開日 | 1998-03-25 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.
Science, 277, 1997
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