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PDB: 1224 results

7XT8
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BU of 7xt8 by Molmil
Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
Deposit date:2022-05-16
Release date:2022-07-27
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7ONG
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BU of 7ong by Molmil
Crystal structure of the computationally designed SAKe6BE-L1 protein
Descriptor: CALCIUM ION, SAKe6BE-L1
Authors:Wouters, S.M.L, Noguchi, H, Velpula, G, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7OPU
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BU of 7opu by Molmil
Self-assembled crystal structure of the computationally designed SAKe6BE-3HH protein
Descriptor: SAKe6BE-3HH
Authors:Wouters, S.M.L, Noguchi, H, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-06-01
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ON8
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BU of 7on8 by Molmil
Crystal structure of the computationally designed SAKe6AR protein
Descriptor: SAKe6AR
Authors:Wouters, S.M.L, Noguchi, H, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ON7
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BU of 7on7 by Molmil
Crystal structure of the computationally designed SAKe6BE-L2 protein
Descriptor: SAKe6BE-L2
Authors:Wouters, S.M.L, Noguchi, H, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ONA
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BU of 7ona by Molmil
Crystal structure of the computationally designed SAKe6AC protein
Descriptor: CALCIUM ION, SAKe6AC
Authors:Wouters, S.M.L, Noguchi, H, Velpula, G, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ONE
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BU of 7one by Molmil
Crystal structure of the self-assembled SAKe6BE designer protein
Descriptor: SAKe6BE
Authors:Wouters, S.M.L, Noguchi, H, Velpula, G, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ONC
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BU of 7onc by Molmil
Crystal structure of the computationally designed SAKe6BE protein
Descriptor: SAKe6BE
Authors:Wouters, S.M.L, Noguchi, H, Velpula, G, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ONH
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BU of 7onh by Molmil
Crystal structure of the computationally designed SAKe6BE-L3 protein
Descriptor: SAKe6BE-L3, SULFATE ION
Authors:Wouters, S.M.L, Noguchi, H, Velpula, G, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7ON6
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BU of 7on6 by Molmil
Crystal structure of the computationally designed SAKe6AE protein
Descriptor: SAKe6AE, SULFATE ION
Authors:Wouters, S.M.L, Noguchi, H, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-25
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7OPV
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BU of 7opv by Molmil
Crystal structure of the computationally designed SAKe6BE-3HH protein, alternative packing
Descriptor: SAKe6BE-3HH
Authors:Wouters, S.M.L, Noguchi, H, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-06-01
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
7OP4
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BU of 7op4 by Molmil
Crystal structure of the computationally designed SAKe6BE-3HH protein
Descriptor: SAKe6BE-3HH
Authors:Wouters, S.M.L, Noguchi, H, Clarke, D.E, Voet, A.R.D, De Feyter, S.
Deposit date:2021-05-29
Release date:2022-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:SAKe: Computationally Designed Modular Protein Building Blocks for Macromolecular Assemblies
To be published
5FOU
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BU of 5fou by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHPA TETRAPEPTIDE
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHPA PEPTIDE, PHOSPHATE ION
Authors:Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
Deposit date:2015-11-26
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
5FOX
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BU of 5fox by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHAA TETRAPEPTIDE
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHAA PEPTIDE, GLYCEROL, ...
Authors:Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
Deposit date:2015-11-26
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
6MG4
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BU of 6mg4 by Molmil
Structure of full-length human lambda-6A light chain JTO
Descriptor: JTO light chain
Authors:Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
Deposit date:2018-09-12
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
8G63
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BU of 8g63 by Molmil
Ralimetinib (LY2228820) in complex with wild type EGFR
Descriptor: Epidermal growth factor receptor, ralimetinib
Authors:Chitnis, S.P, Heppner, D.E.
Deposit date:2023-02-14
Release date:2023-10-11
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor.
Cell Chem Biol, 30, 2023
6MG5
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BU of 6mg5 by Molmil
Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1
Descriptor: 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, Light chain JTO, PHOSPHATE ION
Authors:Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
Deposit date:2018-09-12
Release date:2019-04-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
6M9H
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BU of 6m9h by Molmil
JAK2 JH2 in complex with diaminopyrimidine JAK040
Descriptor: 4-({4-amino-6-[4-(2-hydroxyethyl)-1H-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrile, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Puleo, D.E, Schlessinger, J, Jorgensen, W.L.
Deposit date:2018-08-23
Release date:2018-09-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:JAK2 JH2 Binders
To Be Published
7Z18
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BU of 7z18 by Molmil
E. coli C-P lyase bound to a PhnK ABC dimer and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-05-25
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z19
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BU of 7z19 by Molmil
E. coli C-P lyase bound to a single PhnK ABC domain
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-05-25
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z17
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BU of 7z17 by Molmil
E. coli C-P lyase bound to a PhnK ABC dimer in an open conformation
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-05-25
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
6MG8
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BU of 6mg8 by Molmil
Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched
Descriptor: CHOLESTEROL, Protein patched homolog 1
Authors:Zhang, Y, Bulkley, D, Xin, Y, Roberts, K.J, Asarnow, D.E, Sharma, A, Myers, B.R, Cho, W, Cheng, Y, Beachy, P.A.
Deposit date:2018-09-13
Release date:2018-11-28
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Cell, 175, 2018
7Z15
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BU of 7z15 by Molmil
E. coli C-P lyase bound to a PhnK/PhnL dual ABC dimer and ADP + Pi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-06-22
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (1.93 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z16
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BU of 7z16 by Molmil
E. coli C-P lyase bound to PhnK/PhnL dual ABC dimer with AMPPNP and PhnK E171Q mutation
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI, ...
Authors:Amstrup, S.K, Sofus, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-06-22
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.09 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
6B8J
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BU of 6b8j by Molmil
Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor
Descriptor: CHIR99021, GLYCEROL, Glycogen synthase kinase-3 beta, ...
Authors:Bussiere, D.E.
Deposit date:2017-10-08
Release date:2017-11-08
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
J. Med. Chem., 60, 2017

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