1TG3
| Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II | Descriptor: | Carbonic anhydrase II, SULFATE ION, ZINC ION | Authors: | Fisher, Z, Hernandez Prada, J.A, Tu, C.K, Duda, D, Yoshioka, C, An, H, Govindasamy, L, Silverman, D.N, McKenna, R. | Deposit date: | 2004-05-28 | Release date: | 2005-01-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II Biochemistry, 44, 2005
|
|
5DZQ
| C3larvin toxin, an ADP-ribosyltransferase from Paenibacillus larvae, Orthorhombic Form | Descriptor: | GLYCEROL, MAGNESIUM ION, Toxin-like protein | Authors: | Dutta, D, Ravulapalli, R, Merrill, A.R. | Deposit date: | 2015-09-26 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Structural variability of C3larvin toxin. Intrinsic dynamics of the alpha / beta fold of the C3-like group of mono-ADP-ribosyltransferase toxins. J. Biomol. Struct. Dyn., 34, 2016
|
|
1TKG
| Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with an analog of seryladenylate | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Threonyl-tRNA synthetase | Authors: | Dock-Bregeon, A.C, Rees, B, Torres-Larios, A, Bey, G, Caillet, J, Moras, D. | Deposit date: | 2004-06-08 | Release date: | 2004-11-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Achieving Error-Free Translation; The Mechanism of Proofreading of Threonyl-tRNA Synthetase at Atomic Resolution. Mol.Cell, 16, 2004
|
|
1R4G
| Solution structure of the Sendai virus protein X C-subdomain | Descriptor: | RNA polymerase alpha subunit | Authors: | Blanchard, L, Tarbouriech, N, Blackledge, M, Timmins, P, Burmeister, W.P, Ruigrok, R.W, Marion, D. | Deposit date: | 2003-10-06 | Release date: | 2004-03-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and dynamics of the nucleocapsid-binding domain of the Sendai virus phosphoprotein in solution Virology, 319, 2004
|
|
1SYS
| Crystal structure of HLA, B*4403, and peptide EEPTVIKKY | Descriptor: | Beta-2-microglobulin, Sorting nexin 5, leukocyte antigen (HLA) class I molecule | Authors: | Zernich, D, Purcell, A.W, Macdonald, W.A, Kjer-Nielsen, L, Ely, L.K, Laham, N, Crockford, T, Mifsud, N.A, Tait, B.D, Holdsworth, R, Brooks, A.G, Bottomley, S.P, Beddoe, T, Peh, C.A, Rossjohn, J, McCluskey, J. | Deposit date: | 2004-04-01 | Release date: | 2004-10-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion J.Exp.Med., 200, 2004
|
|
5E3L
| |
5E5M
| Crystal structure of mouse CTLA-4 in complex with nanobody | Descriptor: | CTLA-4 nanobody, Cytotoxic T-lymphocyte protein 4, GLYCEROL | Authors: | Fedorov, A.A, Fedorov, E.V, Samanta, D, Bonanno, J.B, Almo, S.C. | Deposit date: | 2015-10-08 | Release date: | 2016-10-12 | Last modified: | 2019-01-30 | Method: | X-RAY DIFFRACTION (2.182 Å) | Cite: | Crystal structure of mouse CTLA-4 in complex with nanobody To Be Published
|
|
5E7F
| Complex between lactococcal phage Tuc2009 RBP head domain and a nanobody (L06) | Descriptor: | Major structural protein 1, nanobody L06 | Authors: | Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. | Deposit date: | 2015-10-12 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. Mbio, 7, 2016
|
|
1T6M
| X-ray Structure of the R70D PI-PLC enzyme: Insight into the role of calcium and surrounding amino acids on active site geometry and catalysis. | Descriptor: | 1-phosphatidylinositol phosphodiesterase, CALCIUM ION | Authors: | Apiyo, D, Zhao, L, Tsai, M.-D, Selby, T.L. | Deposit date: | 2004-05-06 | Release date: | 2005-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.107 Å) | Cite: | X-ray Structure of the R69D Phosphatidylinositol-Specific Phospholipase C Enzyme: Insight into the Role of Calcium and Surrounding Amino Acids in Active Site Geometry and Catalysis. Biochemistry, 44, 2005
|
|
5HK7
| Bacterial sodium channel pore, 2.95 Angstrom resolution | Descriptor: | 2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}ethyl heptadecanoate, CHLORIDE ION, Ion transport protein, ... | Authors: | Shaya, D, Findeisen, F, Rohaim, A, Minor, D.L. | Deposit date: | 2016-01-14 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell, 164, 2016
|
|
5E7T
| Structure of the tripod (BppUct-A-L) from the baseplate of bacteriophage Tuc2009 | Descriptor: | CALCIUM ION, Major structural protein 1, Minor structural protein 4, ... | Authors: | Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. | Deposit date: | 2015-10-13 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. Mbio, 7, 2016
|
|
1T8I
| Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex | Descriptor: | 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | Authors: | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | Deposit date: | 2004-05-12 | Release date: | 2005-05-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
|
|
5HAM
| |
1SXY
| 1.07 A Crystal Structure of D30N Mutant of Nitrophorin 4 from Rhodnius Prolixus | Descriptor: | AMMONIUM ION, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Maes, E.M, Weichsel, A, Andersen, J.F, Shepley, D, Montfort, W.R. | Deposit date: | 2004-03-31 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Role of binding site loops in controlling nitric oxide release: structure and kinetics of mutant forms of nitrophorin 4 Biochemistry, 43, 2004
|
|
5EA6
| Crystal Structure of Inhibitor BTA-9881 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | (9~{b}~{R})-9~{b}-(4-chlorophenyl)-1-pyridin-3-ylcarbonyl-2,3-dihydroimidazo[5,6]pyrrolo[1,2-~{a}]pyridin-5-one, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
|
|
5HD7
| Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | Descriptor: | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. | Deposit date: | 2016-01-04 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
|
|
5HL7
| The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Eyal, Z, Matzov, D, Krupkin, M, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | Deposit date: | 2016-01-14 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism. Sci Rep, 6, 2016
|
|
4O5T
| Crystal structure of Diels-Alderase CE20 in complex with a product analog | Descriptor: | 4-{[2-(phosphonooxy)ethyl]carbamoyl}benzyl [(1R,6S)-6-(dimethylcarbamoyl)cyclohex-2-en-1-yl]carbamate, Diisopropyl-fluorophosphatase | Authors: | Beck, T, Preiswerk, N, Mayer, C, Hilvert, D. | Deposit date: | 2013-12-20 | Release date: | 2014-06-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
1TN5
| Structure of bacterorhodopsin mutant K41P | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Yang, D, Faham, S, Boulting, G, Whitelegge, J, Bowie, J.U. | Deposit date: | 2004-06-11 | Release date: | 2004-10-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol., 341, 2004
|
|
5HFZ
| Mmi1 YTH domain | Descriptor: | YTH domain-containing protein mmi1 | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | Deposit date: | 2016-01-07 | Release date: | 2016-02-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
|
|
5AZT
| Ternary complex of hPPARalpha ligand binding domain, 17-oxoDHA and a SRC1 peptide | Descriptor: | (4~{Z},7~{Z},10~{Z},13~{Z},19~{Z})-17-oxidanylidenedocosa-4,7,10,13,19-pentaenoic acid, 15-meric peptide from Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor alpha | Authors: | Egawa, D, Itoh, T, Yamamoto, K. | Deposit date: | 2015-10-23 | Release date: | 2016-07-06 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | 17-OxoDHA Is a PPAR alpha/gamma Dual Covalent Modifier and Agonist Acs Chem.Biol., 2016
|
|
5B28
| The 0.90A structure of human FABP3 F16V mutant complexed with palmitic acid | Descriptor: | Fatty acid-binding protein, heart, PALMITIC ACID, ... | Authors: | Matsuoka, D, Sugiyama, S, Kakinouchi, K, Niiyama, M, Murata, M, Matsuoka, S. | Deposit date: | 2016-01-12 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | The 0.90A structure of human FABP3 F16V mutant complexed with palmitic acid. To Be Published
|
|
3EFK
| Structure of c-Met with pyrimidone inhibitor 50 | Descriptor: | 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor | Authors: | Bellon, S.F, D'Angelo, N, Whittington, D, Dussault, I. | Deposit date: | 2008-09-09 | Release date: | 2008-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design, synthesis, and biological evaluation of potent c-Met inhibitors. J.Med.Chem., 51, 2008
|
|
5GAH
| RNC in complex with SRP with detached NG domain | Descriptor: | 1A9L SS, 23S rRNA, 50S ribosomal protein L10, ... | Authors: | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | Deposit date: | 2015-11-26 | Release date: | 2016-01-27 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
|
|
5AQT
| Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | Descriptor: | (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(quinazolin-4-ylamino)cyclopentane-1,2-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... | Authors: | Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. | Deposit date: | 2015-09-22 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
|
|