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PDB: 22297 件
1MYZ
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CO COMPLEX OF MYOGLOBIN MB-YQR AT RT SOLVED FROM LAUE DATA.
分子名称: CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Bourgeois, D, Vallone, B, Schotte, F, Arcovito, A, Miele, A.E, Sciara, G, Wulff, M, Anfinrud, P, Brunori, M.
登録日2002-10-04
公開日2003-08-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Complex landscape of protein structural dynamics unveiled by nanosecond Laue crystallography.
Proc.Natl.Acad.Sci.USA, 100, 2003
1N2H
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BU of 1n2h by Molmil
Crystal Structure of a Pantothenate Synthetase from M. tuberculosis in complex with a reaction intermediate, pantoyl adenylate
分子名称: ETHANOL, GLYCEROL, MANGANESE (II) ION, ...
著者Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
登録日2002-10-22
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
Protein Sci., 12, 2003
8PO4
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Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R]
分子名称: 1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Epidermal growth factor receptor, ...
著者Hargreaves, D.
登録日2023-07-03
公開日2024-06-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.621 Å)
主引用文献Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J.Med.Chem., 67, 2024
8PO3
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Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R]
分子名称: 2-methyl-5-[[3-[1-[(3~{S})-1-propanoylpyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor
著者Hargreaves, D.
登録日2023-07-03
公開日2024-06-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
J.Med.Chem., 67, 2024
3OM4
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Crystal structure of B. megaterium levansucrase mutant K373A
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Levansucrase, ...
著者Strube, C.P, Homann, A, Gamer, M, Jahn, D, Seibel, J, Heinz, D.W.
登録日2010-08-26
公開日2011-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of B. megaterium levansucrase mutant K373A
To be Published
2VWN
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BU of 2vwn by Molmil
Aminopyrrolidine Factor Xa inhibitor
分子名称: 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ...
著者Groebke-Zbinden, K, Banner, D.W, Benz, J.M, Blasco, F, Decoret, G, Himber, J, Kuhn, B, Panday, N, Ricklin, F, Risch, P, Schlatter, D, Stahl, M, Unger, R, Haap, W.
登録日2008-06-26
公開日2009-07-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.
Eur.J.Med.Chem., 44, 2009
1N28
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BU of 1n28 by Molmil
Crystal structure of the H48Q mutant of human group IIA phospholipase A2
分子名称: CALCIUM ION, Phospholipase A2, membrane associated
著者Edwards, S.H, Thompson, D, Baker, S.F, Wood, S.P, Wilton, D.C.
登録日2002-10-22
公開日2003-10-28
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism
Biochemistry, 41, 2002
1N2I
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BU of 1n2i by Molmil
Crystal Structure of Pantothenate Synthetase from M. tuberculosis in complex with a reaction intermediate, pantoyl adenylate, different occupancies of pantoyl adenylate
分子名称: ETHANOL, GLYCEROL, PANTOYL ADENYLATE, ...
著者Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
登録日2002-10-22
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
Protein Sci., 12, 2003
2WCZ
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1.6A resolution structure of Archaeoglobus fulgidus Hjc, a Holliday junction resolvase from an archaeal hyperthermophile
分子名称: CHLORIDE ION, HOLLIDAY JUNCTION RESOLVASE
著者Carolis, C, Koehler, C, Sauter, C, Basquin, J, Suck, D, Toeroe, I.
登録日2009-03-18
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献1.6 A Resolution Structure of Archaeoglobus Fulgidus Hjc, a Holliday Junction Resolvase from an Archaeal Hyperthermophile
To be Published
3OV6
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CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide)
分子名称: 1-O-[(S)-hydroxy{[(4S,8S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-beta-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ...
著者Scharf, L, Li, N.S, Hawk, A.J, Garzon, D, Zhang, T, Kazen, A.R, Shah, S, Haddadian, E.J, Saghatelian, A, Faraldo-Gomez, J.D, Meredith, S.C, Piccirilli, J.A, Adams, E.J.
登録日2010-09-15
公開日2011-01-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献The 2.5 A structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
Immunity, 33, 2010
1MU6
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BU of 1mu6 by Molmil
Crystal Structure of Thrombin in Complex with L-378,622
分子名称: 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE, HIRUDIN IIB, THROMBIN
著者Burgey, C.S, Robinson, K.A, Lyle, T.A, Sanderson, P.E, Lewis, S.D, Lucas, B.J, Krueger, J.A, Singh, R, Miller-Stein, C, White, R.B, Wong, B, Lyle, E.A, Williams, P.D, Coburn, C.A, Dorsey, B.D, Barrow, J.C, Stranieri, M.T, Holahan, M.A, Sitko, G.R, Cook, J.J, McMasters, D.R, McDonough, C.M, Sanders, W.M, Wallace, A.A, Clayton, F.C, Bohn, D, Leonard, Y.M, Detwiler Jr, T.J, Lynch Jr, J.J, Yan, Y, Chen, Z, Kuo, L, Gardell, S.J, Shafer, J.A, Vacca, J.P.J.
登録日2002-09-23
公開日2004-04-06
最終更新日2021-07-21
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
J.Med.Chem., 46, 2003
8QUA
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BU of 8qua by Molmil
GTP binding protein YsxC from Staphylococcus aureus
分子名称: ACETYL GROUP, GLYCEROL, Probable GTP-binding protein EngB
著者Biktimirov, A, Islamov, D, Lazarenko, V, Fatkhullin, B, Validov, S, Yusupov, M, Usachev, K.
登録日2023-10-15
公開日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of GTPase YsxC from Staphylococcus aureus.
Biochem.Biophys.Res.Commun., 699, 2024
2W42
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BU of 2w42 by Molmil
THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX.
分子名称: 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
著者Parker, J.S, Roe, S.M, Barford, D.
登録日2008-11-19
公開日2008-12-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
3OZK
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BU of 3ozk by Molmil
Crystal structure of human transthyretin variant A25T in complex with thyroxine (T4)
分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, Transthyretin
著者Lima, L.M.T.R, Palmieri, L.C, Foguel, D, Palhano, F.L.
登録日2010-09-25
公開日2011-08-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of human transthyretin variant A25T in complex with thyroxine (T4)
To be Published
3OZX
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Crystal structure of ABCE1 of Sulfolubus solfataricus (-FeS domain)
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Barthelme, D, Tampe, R.
登録日2010-09-27
公開日2011-02-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Ribosome Recycling in Archaea A Mechanistic Link between FeS Cluster Biosynthesis and Conformational Switch of Twin-ATPase ABCE1
To be Published
1N5N
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BU of 1n5n by Molmil
Crystal Structure of Peptide Deformylase from Pseudomonas aeruginosa
分子名称: GLYCEROL, Peptide deformylase, ZINC ION
著者Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A.
登録日2002-11-06
公開日2003-06-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
3P0K
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Structure of Baculovirus Sulfhydryl Oxidase Ac92
分子名称: ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ...
著者Hakim, M, Fass, D.
登録日2010-09-29
公開日2011-12-07
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Structure of a baculovirus sulfhydryl oxidase, a highly divergent member of the erv flavoenzyme family.
J.Virol., 85, 2011
3P1W
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Crystal Structure of RAB GDI from Plasmodium Falciparum, PFL2060c
分子名称: RabGDI protein
著者Wernimont, A.K, Neculai, A.M, Weadge, J, MacKenzie, F, Cossar, D, Tempel, W, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Langsley, G, Bosch, J, Hui, R, Pizzaro, J.C, Hutchinson, A, Structural Genomics Consortium (SGC)
登録日2010-09-30
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of RAB GDI from Plasmodium Falciparum, PFL2060c
To be published
2W1B
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The structure of the efflux pump AcrB in complex with bile acid
分子名称: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACRIFLAVIN RESISTANCE PROTEIN B
著者Drew, D, Klepsch, M.M, Newstead, S, Flaig, R, De Gier, J.W, Iwata, S, Beis, K.
登録日2008-10-17
公開日2008-12-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.85 Å)
主引用文献The Structure of the Efflux Pump Acrb in Complex with Bile Acid.
Mol.Membr.Biol., 25, 2008
1N2B
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Crystal Structure of a Pantothenate Synthetase from M. tuberculosis in complex with AMPCPP and pantoate, higher occupancy of pantoate and lower occupancy of AMPCPP in subunit A
分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ETHANOL, GLYCEROL, ...
著者Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
登録日2002-10-22
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
Protein Sci., 12, 2003
1N2O
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BU of 1n2o by Molmil
Crystal Structure of Pantothenate Synthetase from M. tuberculosis, low occupancy of beta-alanine at the pantoate binding sites
分子名称: BETA-ALANINE, SULFATE ION, pantothenate synthetase
著者Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
登録日2002-10-23
公開日2003-04-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
Protein Sci., 12, 2003
4BVK
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BU of 4bvk by Molmil
Structure of Y190E mutant of PhaZ7 PHB depolymerase
分子名称: PHB DEPOLYMERASE PHAZ7
著者Hermawan, S, Subedi, B, Papageorgiou, A.C, Jendrossek, D.
登録日2013-06-26
公開日2013-09-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.606 Å)
主引用文献Biochemical Analysis and Structure Determination of Paucimonas Lemoignei Poly(3-Hydroxybutyrate) (Phb) Depolymerase Phaz7 Muteins Reveal the Phb Binding Site and Details of Substrate-Enzyme Interactions.
Mol.Microbiol., 90, 2013
3P4Y
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BU of 3p4y by Molmil
Helicase domain of reverse gyrase from Thermotoga maritima - P2 form
分子名称: reverse gyrase helicase domain
著者Rudolph, M.G, Klostermeier, D.
登録日2010-10-07
公開日2011-06-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The Conformational Flexibility of the Helicase-like Domain from Thermotoga maritima Reverse Gyrase Is Restricted by the Topoisomerase Domain.
Biochemistry, 50, 2011
3P56
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The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
分子名称: Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C
著者Bubeck, D, Graham, S.C, Jones, E.Y.
登録日2010-10-08
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (4.06 Å)
主引用文献The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease.
J.Biol.Chem., 286, 2011
1MV9
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Crystal Structure of the human RXR alpha ligand binding domain bound to the eicosanoid DHA (Docosa Hexaenoic Acid) and a coactivator peptide
分子名称: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Nuclear receptor coactivator 2, RXR retinoid X receptor
著者Egea, P.F, Mitschler, A, Moras, D.
登録日2002-09-24
公開日2002-10-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Recognition of Agonist Ligands by RXRs
MOL.ENDOCRINOL., 16, 2002

223790

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