5EHC
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | Descriptor: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | Deposit date: | 2015-10-28 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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1MK5
| Wildtype Core-Streptavidin with Biotin at 1.4A. | Descriptor: | BIOTIN, Streptavidin | Authors: | Hyre, D.E, Le Trong, I, Merritt, E.A, Green, N.M, Stenkamp, R.E, Stayton, P.S. | Deposit date: | 2002-08-28 | Release date: | 2003-09-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Cooperative hydrogen bond interactions in the streptavidin-biotin system Protein Sci., 15, 2006
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1ML7
| Crystal structure of nitrophorin 4 complexed with 4-iodopyrazole | Descriptor: | 4-IODOPYRAZOLE, 5,8-DIMETHYL-1,2,3,4-TETRAVINYLPORPHINE-6,7-DIPROPIONIC ACID FERROUS COMPLEX, nitrophorin 4 | Authors: | Berry, R.E, Ding, X.D, Weichsel, A, Montfort, W.R, Walker, F.A. | Deposit date: | 2002-08-30 | Release date: | 2002-09-20 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4 J.Biol.Inorg.Chem., 9, 2004
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6UKS
| ATPgammaS bound mBcs1 | Descriptor: | MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | Deposit date: | 2019-10-05 | Release date: | 2020-02-05 | Last modified: | 2020-02-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. Nat.Struct.Mol.Biol., 27, 2020
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2FN7
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4MDS
| Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and non-covalent nanomolar inhibitors with an induced-fit binding | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, N-[4-(acetylamino)phenyl]-2-(1H-benzotriazol-1-yl)-N-[(1R)-2-[(2-methylbutan-2-yl)amino]-1-(1-methyl-1H-pyrrol-2-yl)-2-oxoethyl]acetamide | Authors: | Mesecar, A.D, Grum-Tokars, V. | Deposit date: | 2013-08-23 | Release date: | 2013-10-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.598 Å) | Cite: | Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorg.Med.Chem.Lett., 23, 2013
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3TB9
| Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-08-05 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
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3TCH
| Crystal structure of E. coli OppA in an open conformation | Descriptor: | Periplasmic oligopeptide-binding protein | Authors: | Klepsch, M.M, Kovermann, M, Low, C, Balbach, J, de Gier, J.W, Slotboom, D.J, Berntsson, R.P.-A. | Deposit date: | 2011-08-09 | Release date: | 2011-10-12 | Last modified: | 2012-01-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Escherichia coli peptide binding protein OppA has a preference for positively charged peptides. J.Mol.Biol., 414, 2011
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5ELH
| Crystal structure of mouse Unkempt zinc fingers 1-3 (ZnF1-3), bound to RNA | Descriptor: | RING finger protein unkempt homolog, RNA (5'-R(*UP*UP*AP*UP*U)-3'), SULFATE ION, ... | Authors: | Teplova, M, Murn, J, Zarnack, K, Shi, Y, Patel, D.J. | Deposit date: | 2015-11-04 | Release date: | 2015-12-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat.Struct.Mol.Biol., 23, 2016
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6UO7
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2QJ2
| A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist | Descriptor: | Hepatocyte growth factor, SULFATE ION | Authors: | Tolbert, W.D, Daugherty, J, Gao, C.-F, Xe, Q, Miranti, C, Gherardi, E, Vande Woude, G, Xu, H.E. | Deposit date: | 2007-07-06 | Release date: | 2007-09-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist Proc.Natl.Acad.Sci.Usa, 104, 2007
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2QJB
| Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION | Authors: | Kotzsch, A, Mueller, T.D. | Deposit date: | 2007-07-06 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
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5EQE
| Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11) | Descriptor: | Choline kinase alpha, [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine | Authors: | Zhou, T, Zhu, X, Dalgarno, D.C. | Deposit date: | 2015-11-12 | Release date: | 2016-01-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery. J.Med.Chem., 59, 2016
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4LUR
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6DGP
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5EIR
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | Descriptor: | Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | Authors: | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | Deposit date: | 2015-10-30 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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4M89
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6UO4
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4LQF
| Structure of murine IgG2b A2C7-Fab in complex with vaccinia antigen A33R at the resolution of 2.3 Angstroms | Descriptor: | A33R, Murine IgG2b A2C7 Heavy chain Fab domain, Murine IgG2b A2C7 Light chain Fab domain, ... | Authors: | Matho, M.H, Schlossman, A.M, Zajonc, D.M. | Deposit date: | 2013-07-17 | Release date: | 2014-08-06 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer. Plos Pathog., 11, 2015
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7XG3
| CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XG0
| CryoEM structure of type IV-A Csf-crRNA-dsDNA ternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XG2
| CryoEM structure of type IV-A NTS-nicked dsDNA bound Csf-crRNA ternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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1MPV
| Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide | Descriptor: | BLyS Receptor 3 | Authors: | Kayagaki, N, Yan, M, Seshasayee, D, Wang, H, Lee, W, French, D.M, Grewal, I.S, Cochran, A.G, Gordon, N.C, Yin, J, Starovasnik, M.A, Dixit, V.M. | Deposit date: | 2002-09-12 | Release date: | 2002-10-30 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity, 17, 2002
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5ELK
| Crystal structure of mouse Unkempt zinc fingers 4-6 (ZnF4-6), bound to RNA | Descriptor: | RING finger protein unkempt homolog, RNA, ZINC ION | Authors: | Teplova, M, Murn, J, Zarnack, K, Shi, Y, Patel, D.J. | Deposit date: | 2015-11-04 | Release date: | 2015-12-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat.Struct.Mol.Biol., 23, 2016
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5EMX
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