5JRL
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7NTD
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![BU of 7ntd by Molmil](/molmil-images/mine/7ntd) | The structure of the SBP TarP_Csal in complex with ferulate | Descriptor: | 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, MAGNESIUM ION, SULFATE ION, ... | Authors: | Bisson, C, Salmon, R.C, West, L, Rafferty, J.B, Hitchcock, A, Thomas, G.H, Kelly, D.J. | Deposit date: | 2021-03-09 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The structural basis for high-affinity uptake of lignin-derived aromatic compounds by proteobacterial TRAP transporters. Febs J., 289, 2022
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7YWP
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![BU of 7ywp by Molmil](/molmil-images/mine/7ywp) | Closed conformation of Oligopeptidase B from Serratia proteomaculans with covalently bound TCK | Descriptor: | N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide, Oligopeptidase B | Authors: | Petrenko, D.E, Boyko, K.M, Nikolaeva, A.Y, Vlaskina, A.V, Mikhailova, A.G, Timofeev, V.I, Rakitina, T.V. | Deposit date: | 2022-02-14 | Release date: | 2023-02-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of Inhibitor-Bound Bacterial Oligopeptidase B in the Closed State: Similarity and Difference between Protozoan and Bacterial Enzymes. Int J Mol Sci, 24, 2023
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6SCM
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![BU of 6scm by Molmil](/molmil-images/mine/6scm) | SOS1 in Complex with Inhibitor BI-3406 | Descriptor: | 1,2-ETHANEDIOL, IMIDAZOLE, Son of sevenless homolog 1, ... | Authors: | Kessler, D, Fischer, G, Ramharter, J. | Deposit date: | 2019-07-24 | Release date: | 2020-08-26 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.866 Å) | Cite: | BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discov, 11, 2021
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6FCN
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7NTE
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![BU of 7nte by Molmil](/molmil-images/mine/7nte) | The structure of an open conformation of the SBP TarP_Csal | Descriptor: | MAGNESIUM ION, TRAP dicarboxylate transporter-DctP subunit | Authors: | Bisson, C, Salmon, R.C, West, L, Rafferty, J.B, Hitchcock, A, Thomas, G.H, Kelly, D.J. | Deposit date: | 2021-03-09 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structural basis for high-affinity uptake of lignin-derived aromatic compounds by proteobacterial TRAP transporters. Febs J., 289, 2022
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5MI9
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![BU of 5mi9 by Molmil](/molmil-images/mine/5mi9) | Structure of the phosphomimetic mutant of the elongation factor EF-Tu T62E | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | Deposit date: | 2016-11-27 | Release date: | 2017-12-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018
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6C97
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![BU of 6c97 by Molmil](/molmil-images/mine/6c97) | Crystal structure of FcRn at pH3 | Descriptor: | Beta-2-microglobulin, GLYCEROL, IgG receptor FcRn large subunit p51 | Authors: | Fox III, D, Fairman, J.W. | Deposit date: | 2018-01-25 | Release date: | 2018-05-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biol., 16, 2018
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6UW3
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![BU of 6uw3 by Molmil](/molmil-images/mine/6uw3) | The crystal structure of FbiA from Mycobacterium Smegmatis, GDP Bound form | Descriptor: | CALCIUM ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Grinter, R, Gillett, D, Cordero, P.R.F, Greening, C. | Deposit date: | 2019-11-04 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria. mSystems, 5, 2020
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8H8Y
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![BU of 8h8y by Molmil](/molmil-images/mine/8h8y) | Crystal structure of AbHheG from Acidimicrobiia bacterium | Descriptor: | GLYCEROL, alpha/beta hydrolase | Authors: | Zhou, C.H, Chen, X, Han, X, Liu, W.D, Wu, Q.Q, Zhu, D.M, Ma, Y.H. | Deposit date: | 2022-10-24 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4-Aryl-2-oxazolidinones from Readily Available Epoxides Acs Catalysis, 13, 2023
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8H3C
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![BU of 8h3c by Molmil](/molmil-images/mine/8h3c) | Crystal structure of M2e Influenza peptide in complex with antibody scFv | Descriptor: | Matrix protein 2, Single Chain Variable Fragment | Authors: | Kumar, U, Madni, Z.K, Gaur, V, Salunke, D.M. | Deposit date: | 2022-10-08 | Release date: | 2023-08-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.43 Å) | Cite: | A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein. J.Biomed.Sci., 30, 2023
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7Q97
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![BU of 7q97 by Molmil](/molmil-images/mine/7q97) | Structure of the bacterial type VI secretion system effector RhsA. | Descriptor: | Rhs family protein | Authors: | Guenther, P, Quentin, D, Ahmad, S, Sachar, K, Gatsogiannis, C, Whitney, J.C, Raunser, S. | Deposit date: | 2021-11-12 | Release date: | 2021-12-22 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of a bacterial Rhs effector exported by the type VI secretion system. Plos Pathog., 18, 2022
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4XXS
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![BU of 4xxs by Molmil](/molmil-images/mine/4xxs) | Crystal structure of BACE1 with a pyrazole-substituted tetrahydropyran thioamidine | Descriptor: | (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine, Beta-secretase 1, DIMETHYL SULFOXIDE, ... | Authors: | Parris, K.D, Pandit, J. | Deposit date: | 2015-01-30 | Release date: | 2015-04-01 | Last modified: | 2015-04-22 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. J.Med.Chem., 58, 2015
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8CEE
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![BU of 8cee by Molmil](/molmil-images/mine/8cee) | Rnase R bound to a 30S degradation intermediate (State I - head-turning) | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | Deposit date: | 2023-02-01 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R. Nature, 626, 2024
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5MMR
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![BU of 5mmr by Molmil](/molmil-images/mine/5mmr) | Crystal Structure of CK2alpha with N-((2-chloro-[1,1'-biphenyl]-4-yl)methyl)butane-1,4-diamine bound | Descriptor: | ACETATE ION, Casein kinase II subunit alpha, PHOSPHATE ION, ... | Authors: | Brear, P, De Fusco, C, Georgiou, K, Iegre, J, Sore, H, Hyvonen, M, Spring, D. | Deposit date: | 2016-12-12 | Release date: | 2017-05-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg. Med. Chem., 25, 2017
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6UXF
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![BU of 6uxf by Molmil](/molmil-images/mine/6uxf) | Structure of V. metoecus NucC, hexamer form | Descriptor: | Vibrio meotecus sp. RC341 NucC | Authors: | Ye, Q, Corbett, K.D. | Deposit date: | 2019-11-07 | Release date: | 2019-12-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol.Cell, 77, 2020
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8CDU
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![BU of 8cdu by Molmil](/molmil-images/mine/8cdu) | Rnase R bound to a 30S degradation intermediate (main state) | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | Deposit date: | 2023-02-01 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R. Nature, 626, 2024
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8CED
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![BU of 8ced by Molmil](/molmil-images/mine/8ced) | Rnase R bound to a 30S degradation intermediate (State I - head-turning) | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | Deposit date: | 2023-02-01 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.15 Å) | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R. Nature, 626, 2024
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5MIF
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![BU of 5mif by Molmil](/molmil-images/mine/5mif) | Crystal structure of carboxyl esterase 2 (TmelEST2) from mycorrhizal fungus Tuber melanosporum | Descriptor: | 'Carboxyl esterase 2, FRAGMENT OF TRITON X-100 | Authors: | Zanotti, G, Vallese, F, Cavazzini, D, Ottonello, S. | Deposit date: | 2016-11-28 | Release date: | 2017-08-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.141 Å) | Cite: | A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mycorrhizal fungus Tuber melanosporum. Sci Rep, 7, 2017
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8CEC
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![BU of 8cec by Molmil](/molmil-images/mine/8cec) | Rnase R bound to a 30S degradation intermediate (State I - head-turning) | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | Deposit date: | 2023-02-01 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R. Nature, 626, 2024
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5CNJ
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![BU of 5cnj by Molmil](/molmil-images/mine/5cnj) | mGlur2 with glutamate analog | Descriptor: | (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2 | Authors: | Monn, J.A, Clawson, D.K. | Deposit date: | 2015-07-17 | Release date: | 2015-09-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J.Med.Chem., 58, 2015
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5JQ0
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![BU of 5jq0 by Molmil](/molmil-images/mine/5jq0) | Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7 | Descriptor: | 1,1-dihydroxy-1,3-dihydro-2,1-benzoxaborol-1-ium, Carbonic anhydrase 2, ZINC ION | Authors: | Alterio, V, Esposito, D, Di Fiore, A, De Simone, G. | Deposit date: | 2016-05-04 | Release date: | 2016-10-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Benzoxaborole as a new chemotype for carbonic anhydrase inhibition. Chem.Commun.(Camb.), 52, 2016
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5MO8
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![BU of 5mo8 by Molmil](/molmil-images/mine/5mo8) | Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound | Descriptor: | 3-[[3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoyl]amino]benzoic acid, ACETATE ION, Casein kinase II subunit alpha, ... | Authors: | Brear, P, De Fusco, C, Georgiou, K, Iegre, J, Sore, H, Hyvonen, M, Spring, D. | Deposit date: | 2016-12-13 | Release date: | 2017-05-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg. Med. Chem., 25, 2017
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4Y1D
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8CDV
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![BU of 8cdv by Molmil](/molmil-images/mine/8cdv) | Rnase R bound to a 30S degradation intermediate (state II) | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | Deposit date: | 2023-02-01 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.73 Å) | Cite: | Structural basis of ribosomal 30S subunit degradation by RNase R. Nature, 626, 2024
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