6DHH
| RT XFEL structure of Photosystem II 400 microseconds after the second illumination at 2.2 Angstrom resolution | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | Kern, J, Chatterjee, R, Young, I.D, Fuller, F.D, Lassalle, L, Ibrahim, M, Gul, S, Fransson, T, Brewster, A.S, Alonso-Mori, R, Hussein, R, Zhang, M, Douthit, L, de Lichtenberg, C, Cheah, M.H, Shevela, D, Wersig, J, Seufert, I, Sokaras, D, Pastor, E, Weninger, C, Kroll, T, Sierra, R.G, Aller, P, Butryn, A, Orville, A.M, Liang, M, Batyuk, A, Koglin, J.E, Carbajo, S, Boutet, S, Moriarty, N.W, Holton, J.M, Dobbek, H, Adams, P.D, Bergmann, U, Sauter, N.K, Zouni, A, Messinger, J, Yano, J, Yachandra, V.K. | 登録日 | 2018-05-20 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of the intermediates of Kok's photosynthetic water oxidation clock. Nature, 563, 2018
|
|
4F4Y
| Y-family DNA polymerase chimera Dbh-Dpo4-Dbh | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*CP*AP*CP*TP*GP*AP*TP*CP*GP*GP*GP*CP*CP*C)-3'), ... | 著者 | Pata, J.D, Wilson, R.C. | 登録日 | 2012-05-11 | 公開日 | 2013-01-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.338 Å) | 主引用文献 | Y-family polymerase conformation is a major determinant of fidelity and translesion specificity. Structure, 21, 2013
|
|
1W5L
| An anti-parallel to parallel switch. | 分子名称: | GENERAL CONTROL PROTEIN GCN4 | 著者 | Yadav, M.K, Leman, L.J, Stout, C.D, Ghadiri, M.R. | 登録日 | 2004-08-07 | 公開日 | 2004-09-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Coiled Coils at the Edge of Configurational Heterogeneity. Structural Analyses of Parallel and Antiparallel Homotetrameric Coiled Coils Reveal Configurational Sensitivity to a Single Solvent-Exposed Amino Acid Substitution. Biochemistry, 45, 2006
|
|
5DM3
| Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, L-glutamine synthetase | 著者 | Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2015-09-07 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP To be published
|
|
2XGK
| Virus like particle of L172W mutant of Minute Virus of Mice - the immunosuppressive strain | 分子名称: | COAT PROTEIN VP2 | 著者 | Plevka, P, Hafenstein, S, Tattersall, P, Cotmore, S, Farr, G, D'Abramo, A, Rossmann, M.G. | 登録日 | 2010-06-04 | 公開日 | 2011-04-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Structure of a Packaging-Defective Mutant of Minute Virus of Mice Indicates that the Genome is Packaged Via a Pore at a 5-Fold Axis. J.Virol., 85, 2011
|
|
3TS7
| CRYSTAL STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE (TARGET EFI-501951) FROM Methylococcus capsulatus | 分子名称: | Geranyltranstransferase, PHOSPHATE ION | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2011-09-12 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
5VQA
| Structure of human TRIP13, ATP-bound form | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Pachytene checkpoint protein 2 homolog | 著者 | Ye, Q, Corbett, K.D. | 登録日 | 2017-05-08 | 公開日 | 2017-06-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J., 36, 2017
|
|
5VSA
| Crystal structure of SsoPox AsA1 mutant (C258L-I261F-W263A) | 分子名称: | Aryldialkylphosphatase, COBALT (II) ION, FE (II) ION, ... | 著者 | Hiblot, J, Gotthard, G, Jacquet, P, Daude, D, Bergonzi, C, Chabriere, E, Elias, M. | 登録日 | 2017-05-11 | 公開日 | 2018-01-10 | 最終更新日 | 2021-08-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase. Sci Rep, 7, 2017
|
|
4O5S
| |
4F4Z
| Y-family DNA polymerase chimera Dpo4-Dpo4-Dbh | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*GP*GP*GP*GP*GP*AP*AP*GP*CP*CP*G)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*CP*CP*CP*GP*GP*CP*TP*TP*CP*CP*CP*CP*CP*T)-3'), ... | 著者 | Pata, J.D, Wilson, R.C. | 登録日 | 2012-05-11 | 公開日 | 2013-01-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.305 Å) | 主引用文献 | Y-family polymerase conformation is a major determinant of fidelity and translesion specificity. Structure, 21, 2013
|
|
5VYE
| |
6D4N
| Crystal structure of a Fc fragment of Rhesus macaque (Macaca mulatta) IgG4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment of IgG4 | 著者 | Gohain, N, Tolbert, W.D, Pazgier, M. | 登録日 | 2018-04-18 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses. Mabs, 11, 2019
|
|
3U6B
| Ef-tu (escherichia coli) in complex with nvp-ldi028 | 分子名称: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Palestrant, D.J. | 登録日 | 2011-10-12 | 公開日 | 2012-02-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. J.Med.Chem., 54, 2011
|
|
1I1D
| CRYSTAL STRUCTURE OF YEAST GNA1 BOUND TO COA AND GLNAC-6P | 分子名称: | 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, COENZYME A, GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE, ... | 著者 | Peneff, C, Mengin-Lecreulx, D, Bourne, Y. | 登録日 | 2001-02-01 | 公開日 | 2001-05-16 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase. J.Biol.Chem., 276, 2001
|
|
1I2Z
| E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654 | 分子名称: | 4-(2-THIENYL)-1-(4-METHYLBENZYL)-1H-IMIDAZOLE, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Heerding, D.A, Miller, W.H, Payne, D.J, Janson, C.A, Qiu, X. | 登録日 | 2001-02-12 | 公開日 | 2002-02-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein
reductase (FabI). Bioorg.Med.Chem.Lett., 11, 2001
|
|
5ECE
| Tankyrase 1 with Phthalazinone 1 | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]phenyl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, ACETATE ION, ... | 著者 | Kazmirski, S.L, Johannes, J, Read, J.A, Howard, T, Larsen, N.A, Ferguson, A.D. | 登録日 | 2015-10-20 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
|
|
4ONM
| Crystal structure of human Mms2/Ubc13 - NSC697923 | 分子名称: | 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran, GLYCEROL, Ubiquitin-conjugating enzyme E2 N, ... | 著者 | Hodge, C.D, Edwards, R.A, Glover, J.N.M. | 登録日 | 2014-01-28 | 公開日 | 2015-05-06 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. Acs Chem.Biol., 10, 2015
|
|
4OPI
| Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. | 分子名称: | Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GERANYLGERANYL DIPHOSPHATE | 著者 | McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. | 登録日 | 2014-02-05 | 公開日 | 2014-07-09 | 最終更新日 | 2014-07-23 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. Structure, 22, 2014
|
|
2FUQ
| Crystal Structure of Heparinase II | 分子名称: | FORMIC ACID, PHOSPHATE ION, ZINC ION, ... | 著者 | Shaya, D, Cygler, M. | 登録日 | 2006-01-27 | 公開日 | 2006-04-18 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal Structure of Heparinase II from Pedobacter heparinus and Its Complex with a Disaccharide Product. J.Biol.Chem., 281, 2006
|
|
5L8C
| Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-039 | 分子名称: | 4-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(2-azanyl-2-oxidanylidene-ethyl)benzamide, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... | 著者 | Singh, A.K, Anthonyrajah, E.S, Brown, D.G. | 登録日 | 2016-06-07 | 公開日 | 2018-03-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. J. Med. Chem., 61, 2018
|
|
4ONS
| Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation | 分子名称: | Catenin alpha-2, Catenin beta-1 | 著者 | Pokutta, S, Choi, H.-J, Ahlsen, G, Hansen, S.D, Weis, W.I. | 登録日 | 2014-01-29 | 公開日 | 2014-04-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and Thermodynamic Characterization of Cadherin beta-Catenin alpha-Catenin Complex Formation. J.Biol.Chem., 289, 2014
|
|
4OST
| Crystal structure of the S505C mutant of TAL effector dHax3 | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 | 著者 | Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. | 登録日 | 2014-02-13 | 公開日 | 2014-05-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | Revisiting the TALE repeat Protein Cell, 5, 2014
|
|
3UCA
| Crystal structure of isoprenoid synthase (target EFI-501974) from clostridium perfringens | 分子名称: | Geranyltranstransferase | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2011-10-26 | 公開日 | 2011-11-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3UD0
| |
5VTJ
| Structure of Pin1 WW Domain Sequence 1 Substituted with [S,S]ACPC | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION | 著者 | Mortenson, D.E, Kreitler, D.F, Thomas, N.C, Gellman, S.H, Forest, K.T. | 登録日 | 2017-05-17 | 公開日 | 2018-02-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Evaluation of beta-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure. Chembiochem, 19, 2018
|
|