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PDB: 28 results

1AWO
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THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES
Descriptor: ABL TYROSINE KINASE
Authors:Cowburn, D.
Deposit date:1997-10-03
Release date:1998-01-28
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
Structure, 3, 1995
1JEG
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BU of 1jeg by Molmil
Solution structure of the SH3 domain from C-terminal Src Kinase complexed with a peptide from the tyrosine phosphatase PEP
Descriptor: HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE 70Z-PEP, TYROSINE-PROTEIN KINASE CSK
Authors:Ghose, R, Shekhtman, A, Goger, M.J, Ji, H, Cowburn, D.
Deposit date:2001-06-17
Release date:2001-10-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A novel, specific interaction involving the Csk SH3 domain and its natural ligand.
Nat.Struct.Biol., 8, 2001
7SGT
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BU of 7sgt by Molmil
Domain III (EDIII) of the POWV E glycoprotein
Descriptor: Envelope protein E
Authors:Harris, R, Cahill, S.M, Cowburn, D.
Deposit date:2021-10-07
Release date:2022-05-18
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice.
Plos Pathog., 18, 2022
5TVZ
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BU of 5tvz by Molmil
Solution NMR structure of Saccharomyces cerevisiae Pom152 Ig-like repeat, residues 718-820
Descriptor: Nucleoporin POM152
Authors:Dutta, K, Sampathkumar, P, Cowburn, D, Almo, S.C, Rout, M.P, Fernandez-Martinez, J.
Deposit date:2016-11-10
Release date:2017-02-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.
Structure, 25, 2017
6AX5
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BU of 6ax5 by Molmil
RPT1 region of INI1/SNF5/SMARCB1_HUMAN - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.
Descriptor: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Authors:Girvin, M.E, Cahill, S.M, Harris, R, Cowburn, D, Spira, M, Wu, X, Prakash, R, Bernowitz, M, Almo, S.C, Kalpana, G.V.
Deposit date:2017-09-06
Release date:2017-10-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.
Nat Commun, 12, 2021
6DSL
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BU of 6dsl by Molmil
Consensus engineered intein (Cat) with atypical split site
Descriptor: Consensus engineered intein CatC, Consensus engineered intein CatN
Authors:Sekar, G, Stevens, A.J, Muir, T.W, Cowburn, D.
Deposit date:2018-06-14
Release date:2018-09-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:An Atypical Mechanism of Split Intein Molecular Recognition and Folding.
J. Am. Chem. Soc., 140, 2018
4HDI
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BU of 4hdi by Molmil
Crystal Structure of 3E5 IgG3 FAB from mus musculus
Descriptor: Ig heavy chain V region RF, Ig gamma-3 chain C region, Kappa light chain variable region, ...
Authors:Janda, A, Eryilmaz, E, Kim, J, Cordero, R.J.B, Cowburn, D, Casadevall, A.
Deposit date:2012-10-02
Release date:2013-04-17
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.449 Å)
Cite:Global structures of IgG isotypes expressing identical variable regions.
Mol.Immunol., 56, 2013
1Z66
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BU of 1z66 by Molmil
NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)
Descriptor: Major envelope protein E
Authors:Mukherjee, M, Dutta, K, White, M.A, Cowburn, D, Fox, R.O.
Deposit date:2005-03-21
Release date:2006-03-28
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition.
Protein Sci., 15, 2006
1XBH
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A BETA-HAIRPIN MIMIC FROM FCERI-ALPHA-CYCLO(L-262)
Descriptor: PROTEIN (CYCLO(L-262))
Authors:Mcdonnell, J.M, Fushman, D, Cahill, S.M, Sutton, B.J, Cowburn, D.
Deposit date:1999-02-17
Release date:1999-02-21
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Solution Structures of FceRI Alpha-Chain Mimics: A Beta-Hairpin Peptide and Its Retroenantiomer
J.Am.Chem.Soc., 119, 1997
2L6E
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BU of 2l6e by Molmil
NMR Structure of the monomeric mutant C-terminal domain of HIV-1 Capsid in complex with stapled peptide Inhibitor
Descriptor: Capsid protein p24, NYAD-13 stapled peptide inhibitor
Authors:Bhattacharya, S, Zhang, H, Debnath, A.K, Cowburn, D.
Deposit date:2010-11-18
Release date:2010-12-29
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid.
J.Biol.Chem., 283, 2008
1G84
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THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE
Descriptor: IMMUNOGLOBULIN E
Authors:McDonnell, J.M, Cowburn, D, Gould, H.J, Sutton, B.J, Calvert, R, Beavil, R.E, Beavil, A.J, Henry, A.J.
Deposit date:2000-11-16
Release date:2001-05-16
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
Nat.Struct.Biol., 8, 2001
2GG1
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BU of 2gg1 by Molmil
NMR solution structure of domain III of the E-protein of tick-borne Langat flavivirus (includes RDC restraints)
Descriptor: Genome polyprotein
Authors:Mukherjee, M, Dutta, K, White, M.A, Cowburn, D, Fox, R.O.
Deposit date:2006-03-23
Release date:2006-04-25
Last modified:2023-11-29
Method:SOLUTION NMR
Cite:NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition.
Protein Sci., 15, 2006
2K6X
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Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1- Induced Compacted Structure
Descriptor: RNA polymerase sigma factor rpoD
Authors:Schwartz, E.C, Shekhtman, A, Dutta, K, Pratt, M.R, Cowburn, D, Darst, S, Muir, T.W.
Deposit date:2008-07-28
Release date:2008-10-28
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Autoregulation of a Group 1 Bacterial Sigma Factor Involves the Formation of a Region 1.1 - Induced Compacted Structure
Chem.Biol., 15, 2008
3EAZ
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BU of 3eaz by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant.
Descriptor: Tyrosine-protein kinase CSK
Authors:Liu, D, Seidel, R.D, Cowburn, D.
Deposit date:2008-08-26
Release date:2009-11-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
3EAC
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BU of 3eac by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form.
Descriptor: Tyrosine-protein kinase CSK
Authors:Liu, D, Seidel, R.D, Cowburn, D.
Deposit date:2008-08-25
Release date:2009-11-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
3BRH
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BU of 3brh by Molmil
Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide
Descriptor: Lck Active Site Peptide, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 22
Authors:Seidel, R.D, Love, J, Piserchio, A, Cowburn, D.
Deposit date:2007-12-21
Release date:2009-02-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases
To be Published
2M0V
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BU of 2m0v by Molmil
Complex structure of C-terminal CFTR peptide and extended PDZ2 domain from NHERF1
Descriptor: C-terminal CFTR peptide, Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S, Ju, J.H, Cowburn, D, Bu, Z.
Deposit date:2012-11-06
Release date:2013-04-24
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
2M0T
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BU of 2m0t by Molmil
Structural characterization of the extended PDZ1 domain from NHERF1
Descriptor: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S, Ju, J.H, Cowburn, D, Bu, Z.
Deposit date:2012-11-06
Release date:2013-04-24
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
2M0U
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BU of 2m0u by Molmil
Complex structure of C-terminal CFTR peptide and extended PDZ1 domain from NHERF1
Descriptor: C-terminal CFTR peptide, Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S, Ju, J.H, Cowburn, D, Bu, Z.
Deposit date:2012-11-06
Release date:2013-04-24
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Ligand-Induced Dynamic Changes in Extended PDZ Domains from NHERF1.
J.Mol.Biol., 425, 2013
2GGR
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BU of 2ggr by Molmil
Solution structure of the C-terminal SH3 domain of c-CrkII
Descriptor: Proto-oncogene C-crk
Authors:Muralidharan, V, Dutta, K, Muir, T.W, Cowburn, D.
Deposit date:2006-03-24
Release date:2006-08-01
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution Structure and Folding Characteristics of the C-Terminal SH3 Domain of c-Crk-II
Biochemistry, 45, 2006
1DDB
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BU of 1ddb by Molmil
STRUCTURE OF MOUSE BID, NMR, 20 STRUCTURES
Descriptor: PROTEIN (BID)
Authors:Mcdonnell, J.M, Fushman, D, Milliman, C, Korsmeyer, S.J, Cowburn, D.
Deposit date:1999-02-19
Release date:1999-08-30
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists.
Cell(Cambridge,Mass.), 96, 1999
2KJD
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BU of 2kjd by Molmil
Solution structure of extended PDZ2 domain from NHERF1 (150-270)
Descriptor: Sodium/hydrogen exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S, Cowburn, D, Bu, Z.
Deposit date:2009-05-27
Release date:2009-12-29
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A dynamic intramolecular conformational switch autoregulates the scaffolding protein NHERF1
To be Published
1AB2
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BU of 1ab2 by Molmil
THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL
Descriptor: C-ABL TYROSINE KINASE SH2 DOMAIN
Authors:Overduin, M, Rios, C.B, Mayer, B.J, Baltimore, D, Cowburn, D.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the src homology 2 domain of c-abl.
Cell(Cambridge,Mass.), 70, 1992
2KRG
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Solution Structure of human sodium/ hydrogen exchange regulatory factor 1(150-358)
Descriptor: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Authors:Bhattacharya, S, Dai, Z, Li, J, Baxter, S, Callaway, D.J.E, Cowburn, D, Bu, Z.
Deposit date:2009-12-17
Release date:2009-12-29
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
J.Biol.Chem., 285, 2010
1AWE
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BU of 1awe by Molmil
HUMAN SOS1 PLECKSTRIN HOMOLOGY (PH) DOMAIN, NMR, 20 STRUCTURES
Descriptor: SOS1
Authors:Zheng, J, Cowburn, D.
Deposit date:1997-10-01
Release date:1998-02-25
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.
J.Biol.Chem., 272, 1997

 

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