1F8D
 
 | | Native Influenza Neuraminidase in Complex with 9-amino-2-deoxy-2,3-dehydro-N-neuraminic Acid | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-AMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, ... | | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | | 登録日 | 2000-06-30 | | 公開日 | 2001-04-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
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1F8E
 | | Native Influenza Neuraminidase in Complex with 4,9-diamino-2-deoxy-2,3-dehydro-N-acetyl-neuraminic Acid | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,9-AMINO-2,4-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, CALCIUM ION, ... | | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | | 登録日 | 2000-06-30 | | 公開日 | 2001-04-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
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2V6Q
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2VTY
 | | Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain swapped dimer | | 分子名称: | PROTEIN F1 | | 著者 | Kvansakul, M, Yang, H, Fairlie, W.D, Czabotar, P.E, Fischer, S.F, Perugini, M.A, Huang, D.C.S, Colman, P.M. | | 登録日 | 2008-05-19 | | 公開日 | 2008-06-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Vaccinia Virus Anti-Apoptotic F1L is a Novel Bcl-2-Like Domain-Swapped Dimer that Binds a Highly Selective Subset of Bh3-Containing Death Ligands.
Cell Death Differ., 15, 2008
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2WH6
 | | Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain | | 分子名称: | BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ... | | 著者 | Kvansakul, M, Huang, D.C.S, Colman, P.M. | | 登録日 | 2009-05-01 | | 公開日 | 2010-05-26 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
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2WBF
 | | Crystal Structure Analysis of SERA5E from plasmodium falciparum with loop 690-700 ordered | | 分子名称: | CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Smith, B.J, Malby, R.L, Colman, P.M, Clarke, O.B. | | 登録日 | 2009-02-27 | | 公開日 | 2009-03-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
J. Mol. Biol., 392, 2009
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1L7H
 | | Crystal structure of R292K mutant influenza virus neuraminidase in complex with BCX-1812 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, ... | | 著者 | Smith, B.J, McKimm-Breshkin, J.L, McDonald, M, Fernley, R.T, Varghese, J.N, Colman, P.M. | | 登録日 | 2002-03-15 | | 公開日 | 2002-05-29 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
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1F8B
 | | Native Influenza Virus Neuraminidase in Complex with NEU5AC2EN | | 分子名称: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | | 登録日 | 2000-06-30 | | 公開日 | 2001-04-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase.
Protein Sci., 10, 2001
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4D2M
 | | Vaccinia Virus F1L bound to Bim BH3 | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, BCL-2-LIKE PROTEIN 11, CHLORIDE ION, ... | | 著者 | Kvansakul, M, Colman, P.M. | | 登録日 | 2014-05-12 | | 公開日 | 2014-06-04 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Insight Into Bh3-Domain Binding of Vaccinia Virus Anti-Apoptotic F1L.
J.Virol., 88, 2014
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4BDU
 | | Bax BH3-in-Groove dimer (GFP) | | 分子名称: | GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX | | 著者 | Czabotar, P.E, Colman, P.M. | | 登録日 | 2012-10-08 | | 公開日 | 2013-02-13 | | 最終更新日 | 2019-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.998 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4C5D
 | | Crystal structure of Bcl-xL in complex with benzoylurea compound (42) | | 分子名称: | (R)-3-(4-BROMOBENZYLTHIO)-2-(3-(3-((2,4-DIFLUOROPHENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ... | | 著者 | Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2013-09-11 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
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5WDD
 | | Crystal structure of chicken BOK | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2-related ovarian killer protein | | 著者 | Cowan, A.D, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-07-04 | | 公開日 | 2018-02-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | | 主引用文献 | Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
Cell, 173, 2018
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4BD8
 | | Bax domain swapped dimer induced by BimBH3 with CHAPS | | 分子名称: | 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD7
 | | Bax domain swapped dimer induced by octylmaltoside | | 分子名称: | APOPTOSIS REGULATOR BAX, CHLORIDE ION, PRASEODYMIUM ION | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD2
 | | Bax domain swapped dimer in complex with BidBH3 | | 分子名称: | APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-04 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD6
 | | Bax domain swapped dimer in complex with BaxBH3 | | 分子名称: | APOPTOSIS REGULATOR BAX | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4D2L
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4C52
 | | Crystal structure of Bcl-xL in complex with benzoylurea compound (39b) | | 分子名称: | (R)-2-(3-(3-((2,4-DIFLUOROPENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)-3-(ISOBUTYLTHIO) PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ... | | 著者 | Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2013-09-10 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
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1PHS
 | | THE THREE-DIMENSIONAL STRUCTURE OF THE SEED STORAGE PROTEIN PHASEOLIN AT 3 ANGSTROMS RESOLUTION | | 分子名称: | PHASEOLIN, BETA-TYPE PRECURSOR | | 著者 | Lawrence, M.C, Suzuki, E, Varghese, J.N, Davis, P.C, Vandonkelaar, A, Tulloch, P.A, Colman, P.M. | | 登録日 | 1990-03-21 | | 公開日 | 1990-10-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.
EMBO J., 9, 1990
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1NMA
 | | N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE-ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB NC10, N9 NEURAMINIDASE, ... | | 著者 | Tulip, W.R, Varghese, J.N, Colman, P.M. | | 登録日 | 1994-05-06 | | 公開日 | 1995-09-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data.
Biochemistry, 33, 1994
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1NMC
 | | COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE, ... | | 著者 | Malby, R.L, Mccoy, A.J, Kortt, A.A, Hudson, P.J, Colman, P.M. | | 登録日 | 1997-12-21 | | 公開日 | 1998-09-23 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Three-dimensional structures of single-chain Fv-neuraminidase complexes.
J.Mol.Biol., 279, 1998
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1L7G
 | | Crystal structure of E119G mutant influenza virus neuraminidase in complex with BCX-1812 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, ... | | 著者 | Smith, B.J, McKimm-Breshkin, J.L, McDonald, M, Fernley, R.T, Varghese, J.N, Colman, P.M. | | 登録日 | 2002-03-15 | | 公開日 | 2002-05-29 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
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1NAL
 | | THE THREE-DIMENSIONAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM ESCHERICHIA COLI | | 分子名称: | N-ACETYLNEURAMINATE LYASE, SULFATE ION | | 著者 | Izard, T, Lawrence, M.C, Malby, R.L, Lilley, G.G, Colman, P.M. | | 登録日 | 1994-02-28 | | 公開日 | 1995-09-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli.
Structure, 2, 1994
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1NN2
 | | THREE-DIMENSIONAL STRUCTURE OF THE NEURAMINIDASE OF INFLUENZA VIRUS A(SLASH)TOKYO(SLASH)3(SLASH)67 AT 2.2 ANGSTROMS RESOLUTION | | 分子名称: | 2-acetamido-2-deoxy-4-O-sulfo-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Varghese, J.N, Colman, P.M. | | 登録日 | 1991-03-28 | | 公開日 | 1992-07-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution.
J.Mol.Biol., 221, 1991
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