3I6O
 
 | | Crystal structure of wild type HIV-1 protease with macrocyclic inhibitor GRL-0216A | | Descriptor: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-1-benzyl-2-hydroxy-3-[(7E)-13-methoxy-1,1-dioxido-3,4,5,6,9,10-hexahydro-2H-11,1,2-benzoxathiazacyclotridecin-2-yl]propyl}carbamate, GLYCEROL, IODIDE ION, ... | | Authors: | Chumanevich, A.A, Wang, Y.-F, Kovalevsky, A.Y, Weber, I.T. | | Deposit date: | 2009-07-07 | | Release date: | 2009-09-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance.
J.Med.Chem., 52, 2009
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3B80
 | | HIV-1 protease mutant I54V complexed with gem-diol-amine intermediate NLLTQI | | Descriptor: | CHLORIDE ION, Protease, SODIUM ION, ... | | Authors: | Chumanevich, A.A, Kovalevsky, A.Y, Weber, I.T. | | Deposit date: | 2007-10-31 | | Release date: | 2007-12-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate.
Biochemistry, 46, 2007
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1S3I
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3AMI
 | | The crystal structure of the M16B metallopeptidase subunit from Sphingomonas sp. A1 | | Descriptor: | zinc peptidase | | Authors: | Maruyama, Y, Chuma, A, Mikami, B, Hashimoto, W, Murata, K. | | Deposit date: | 2010-08-20 | | Release date: | 2011-02-02 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Heterosubunit composition and crystal structures of a novel bacterial M16B metallopeptidase
J.Mol.Biol., 407, 2011
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3AMJ
 | | The crystal structure of the heterodimer of M16B peptidase from Sphingomonas sp. A1 | | Descriptor: | ZINC ION, zinc peptidase active subunit, zinc peptidase inactive subunit | | Authors: | Maruyama, Y, Chuma, A, Mikami, B, Hashimoto, W, Murata, K. | | Deposit date: | 2010-08-20 | | Release date: | 2011-02-09 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Heterosubunit composition and crystal structures of a novel bacterial M16B metallopeptidase
J.Mol.Biol., 407, 2011
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3B7V
 | | HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI | | Descriptor: | CHLORIDE ION, GLYCEROL, Protease, ... | | Authors: | Kovalevsky, A.Y, Chumanevich, A.A, Weber, I.T. | | Deposit date: | 2007-10-31 | | Release date: | 2007-12-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate.
Biochemistry, 46, 2007
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3B1U
 | | Crystal structure of human peptidylarginine deiminase 4 in complex with o-F-amidine | | Descriptor: | 2-{[(2S)-1-amino-5-{[(1Z)-2-fluoroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, CALCIUM ION, Protein-arginine deiminase type-4, ... | | Authors: | Causey, C.P, Jones, J.E, Slack, J.L, Kamei, D, Jones Jr, L.E, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, A.A, Luo, Y, Hashimoto, H, Shimizu, T, Sato, M, Hofseth, L.J, Thompson, P.R. | | Deposit date: | 2011-07-13 | | Release date: | 2011-10-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors
J.Med.Chem., 54, 2011
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3B1T
 | | Crystal structure of human peptidylarginine deiminase 4 in complex with o-Cl-amidine | | Descriptor: | 2-{[(2S)-1-amino-5-{[(1Z)-2-chloroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, CALCIUM ION, Protein-arginine deiminase type-4, ... | | Authors: | Causey, C.P, Jones, J.E, Slack, J.L, Kamei, D, Jones Jr, L.E, Subramanian, V, Knuckley, B, Ebrahimi, P, Chumanevich, A.A, Luo, Y, Hashimoto, H, Shimizu, T, Sato, M, Hofseth, L.J, Thompson, P.R. | | Deposit date: | 2011-07-13 | | Release date: | 2011-10-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors
J.Med.Chem., 54, 2011
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1F6L
 | | VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY | | Descriptor: | ANTI-FERRITIN IMMUNOGLOBULIN LIGHT CHAIN | | Authors: | Nymalm, Y, Kravchuk, Z, Salminen, T, Chumanevich, A.A, Dubnovitsky, A.P, Kankare, J, Pentikainen, O, Lehtonen, J, Arosio, P, Martsev, S, Johnson, M.S. | | Deposit date: | 2000-06-22 | | Release date: | 2002-10-23 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Antiferritin VL homodimer binds human spleen ferritin with high specificity
J.STRUCT.BIOL., 138, 2002
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3GUB
 | | Crystal structure of DAPKL93G complexed with N6-(2-Phenylethyl)adenosine | | Descriptor: | 9-alpha-L-lyxofuranosyl-N-(2-phenylethyl)-9H-purin-6-amine, Death-associated protein kinase 1, SULFATE ION | | Authors: | McNamara, L.K, Schumacher, A.M, Schavocky, J.S, Watterson, D.M, Brunzelle, J.S. | | Deposit date: | 2009-03-29 | | Release date: | 2010-03-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Crystal structures of the DAPK gatekeeper mutant complexed with N6-modified adenosine analogs.
To be Published
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3GU8
 | | Crystal structure of DAPKL93G with N6-cyclopentyladenosine | | Descriptor: | Death-associated protein kinase 1, N6-cyclopentyladenosine | | Authors: | McNamara, L.K, Schumacher, A.M, Schavocky, J.S, Watterson, D.M, Brunzelle, J.S. | | Deposit date: | 2009-03-28 | | Release date: | 2010-03-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of the DAPK gatekeeper mutant with N6-modified adenosine analogs.
To be Published
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