7D5E
 
 | | Left-handed G-quadruplex containing two bulges | | Descriptor: | 2xBulge-LHG4motif, POTASSIUM ION, SODIUM ION, ... | | Authors: | Das, P, Maity, A, Ngo, K.H, Winnerdy, F.R, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | | Deposit date: | 2020-09-25 | | Release date: | 2021-02-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.296 Å) | | Cite: | Bulges in left-handed G-quadruplexes.
Nucleic Acids Res., 49, 2021
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7DFY
 | | Novel motif for left-handed G-quadruplex formation | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2xMotif2, POTASSIUM ION, ... | | Authors: | Das, P, Winnerdy, F.R, Maity, A, Mechulam, Y, Phan, A.T. | | Deposit date: | 2020-11-10 | | Release date: | 2021-09-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | A novel minimal motif for left-handed G-quadruplex formation.
Chem.Commun.(Camb.), 57, 2021
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7D5F
 | | Left-handed G-quadruplex containing 3 bulges | | Descriptor: | 3xBulge-LHG4motif | | Authors: | Winnerdy, F.R, Das, P, Ngo, K.H, Maity, A, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | | Deposit date: | 2020-09-25 | | Release date: | 2021-02-10 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Bulges in left-handed G-quadruplexes.
Nucleic Acids Res., 49, 2021
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6JCE
 | | NMR solution and X-ray crystal structures of a DNA containing both right-and left-handed parallel-stranded G-quadruplexes | | Descriptor: | 29-mer DNA | | Authors: | Winnerdy, F.R, Bakalar, B, Maity, A, Vandana, J.J, Mechulam, Y, Schmitt, E, Phan, A.T. | | Deposit date: | 2019-01-28 | | Release date: | 2019-07-10 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.
Nucleic Acids Res., 47, 2019
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3FZG
 | | Structure of the 16S rRNA methylase ArmA | | Descriptor: | 16S rRNA methylase, S-ADENOSYLMETHIONINE | | Authors: | Schmitt, E, Galimand, M, Panvert, M, Courvalin, P, Mechulam, Y. | | Deposit date: | 2009-01-26 | | Release date: | 2009-08-11 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
J.Mol.Biol., 388, 2009
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3FRI
 | | Structure of the 16S rRNA methylase RmtB, I222 | | Descriptor: | 16S rRNA methylase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Schmitt, E, Galimand, M, Panvert, M, Dupechez, M, Courvalin, P, Mechulam, Y. | | Deposit date: | 2009-01-08 | | Release date: | 2009-08-11 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
J.Mol.Biol., 388, 2009
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3H9B
 | | Structure of a mutant methionyl-tRNA synthetase with modified specificity complexed with azidonorleucine | | Descriptor: | 6-azido-L-norleucine, CITRIC ACID, Methionyl-tRNA synthetase, ... | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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1XTY
 | | Crystal structure of Sulfolobus solfataricus peptidyl-tRNA hydrolase | | Descriptor: | Peptidyl-tRNA hydrolase, SULFATE ION | | Authors: | Fromant, M, Schmitt, E, Mechulam, Y, Lazennec, C, Plateau, P, Blanquet, S. | | Deposit date: | 2004-10-25 | | Release date: | 2005-03-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolase.
Biochemistry, 44, 2005
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3H99
 | | Structure of a mutant methionyl-tRNA synthetase with modified specificity complexed with methionine | | Descriptor: | CITRIC ACID, METHIONINE, Methionyl-tRNA synthetase, ... | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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3H97
 | | Structure of a mutant methionyl-tRNA synthetase with modified specificity | | Descriptor: | CITRIC ACID, Methionyl-tRNA synthetase, ZINC ION | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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3H9C
 | | Structure of methionyl-tRNA synthetase: crystal form 2 | | Descriptor: | CITRIC ACID, Methionyl-tRNA synthetase, ZINC ION | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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1RQG
 | | Methionyl-tRNA synthetase from Pyrococcus abyssi | | Descriptor: | Methionyl-tRNA synthetase, ZINC ION | | Authors: | Crepin, T, Schmitt, E, Blanquet, S, Mechulam, Y. | | Deposit date: | 2003-12-05 | | Release date: | 2004-05-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi.
Biochemistry, 43, 2004
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7YZN
 | | Structure of C-terminally truncated aIF5B from Pyrococcus abyssi complexed with GTP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable translation initiation factor IF-2, ... | | Authors: | Bourgeois, G, Schmitt, E, Mechulam, Y, Coureux, P.D, Kazan, R. | | Deposit date: | 2022-02-21 | | Release date: | 2022-06-29 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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7YYP
 | | Structure of aIF5B from Pyrococcus abyssi complexed with GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, NITRATE ION, Probable translation initiation factor IF-2 | | Authors: | Bourgeois, G, Schmitt, E, Mechulam, Y, Coureux, P.D, Kazan, R. | | Deposit date: | 2022-02-18 | | Release date: | 2022-06-29 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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7ZAI
 | | Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA and aIF1A. | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | Deposit date: | 2022-03-22 | | Release date: | 2022-07-13 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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7ZAG
 | | Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA,mRNA, aIF1A and the C-terminal domain of aIF5B. | | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | Authors: | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | Deposit date: | 2022-03-22 | | Release date: | 2022-08-03 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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7ZAH
 | | Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA, aIF1A and aIF5B | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | Deposit date: | 2022-03-22 | | Release date: | 2022-08-03 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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3B2R
 | | Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil | | Descriptor: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase | | Authors: | Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. | | Deposit date: | 2007-10-19 | | Release date: | 2008-05-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol., 73, 2008
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1FMT
 | | METHIONYL-TRNAFMET FORMYLTRANSFERASE FROM ESCHERICHIA COLI | | Descriptor: | METHIONYL-TRNA FMET FORMYLTRANSFERASE | | Authors: | Schmitt, E, Mechulam, Y. | | Deposit date: | 1997-10-13 | | Release date: | 1998-01-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase.
EMBO J., 15, 1996
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1JKE
 | | D-Tyr tRNATyr deacylase from Escherichia coli | | Descriptor: | D-Tyr-tRNATyr deacylase, ZINC ION | | Authors: | Ferri-Fioni, M.L, Schmitt, E, Soutourina, J, Plateau, P, Mechulam, Y, Blanquet, S. | | Deposit date: | 2001-07-12 | | Release date: | 2002-01-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure of crystalline D-Tyr-tRNA(Tyr) deacylase. A representative of a new class of tRNA-dependent hydrolases.
J.Biol.Chem., 276, 2001
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