8BRV
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![BU of 8brv by Molmil](/molmil-images/mine/8brv) | Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C complexed with beta3-methionine. | Descriptor: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ... | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | Deposit date: | 2022-11-24 | Release date: | 2023-08-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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8BRU
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![BU of 8bru by Molmil](/molmil-images/mine/8bru) | Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C | Descriptor: | CITRIC ACID, Methionine--tRNA ligase, ZINC ION | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | Deposit date: | 2022-11-24 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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4U5M
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![BU of 4u5m by Molmil](/molmil-images/mine/4u5m) | Structure of a left-handed DNA G-quadruplex | Descriptor: | DNA (28-MER), MAGNESIUM ION, POTASSIUM ION | Authors: | Schmitt, E, Mechulam, Y, Phan, A.T, Brahim, H, Chung, W.J, Lim, K.W. | Deposit date: | 2014-07-25 | Release date: | 2015-02-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of a left-handed DNA G-quadruplex. Proc.Natl.Acad.Sci.USA, 112, 2015
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6Y4B
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![BU of 6y4b by Molmil](/molmil-images/mine/6y4b) | |
6Y3G
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![BU of 6y3g by Molmil](/molmil-images/mine/6y3g) | Crystal structure of phenylalanine tRNA from Escherichia coli | Descriptor: | CALCIUM ION, GLYCEROL, GUANIDINE, ... | Authors: | Bourgeois, G, Mechulam, Y, Schmitt, E. | Deposit date: | 2020-02-18 | Release date: | 2020-12-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis of the interaction between cyclodipeptide synthases and aminoacylated tRNA substrates. Rna, 26, 2020
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5C6F
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![BU of 5c6f by Molmil](/molmil-images/mine/5c6f) | Crystal structures of ferritin mutants reveal side-on binding to diiron and end-on cleavage of oxygen | Descriptor: | Bacterial non-heme ferritin, FE (III) ION, IMIDAZOLE | Authors: | Kim, S, Kim, K.H, Seok, J.H, Park, Y.H, Jung, S.W, Chung, Y.B, Lee, D.B, Lee, J.H, Han, K.R, Cho, A.E, Lee, C, Chung, M.S. | Deposit date: | 2015-06-23 | Release date: | 2016-07-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. J. Mol. Biol., 428, 2016
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4ZTT
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![BU of 4ztt by Molmil](/molmil-images/mine/4ztt) | Crystal structures of ferritin mutants reveal diferric-peroxo intermediates | Descriptor: | Bacterial non-heme ferritin, FE (II) ION, FE (III) ION, ... | Authors: | Kim, S, Park, Y.H, Jung, S.W, Seok, J.H, Chung, Y.B, Lee, D.B, Gowda, G, Lee, J.H, Han, H.R, Cho, A.E, Lee, C, Chung, M.S, Kim, K.H. | Deposit date: | 2015-05-15 | Release date: | 2016-06-15 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. J. Mol. Biol., 428, 2016
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4RCZ
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![BU of 4rcz by Molmil](/molmil-images/mine/4rcz) | Structure of aIF2-gamma D19A variant from Sulfolobus solfataricus bound to GDPNP | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Dubiez, E, Aleksandrov, A, Lazennec-Schurdevin, C, Mechulam, Y, Schmitt, E. | Deposit date: | 2014-09-18 | Release date: | 2015-05-27 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.429 Å) | Cite: | Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2. Nucleic Acids Res., 43, 2015
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4RD6
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![BU of 4rd6 by Molmil](/molmil-images/mine/4rd6) | Structure of aIF2-gamma from Sulfolobus solfataricus bound to GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Translation initiation factor 2 subunit gamma | Authors: | Dubiez, E, Aleksandrov, A, Lazennec-Schurdevin, C, Mechulam, Y, Schmitt, E. | Deposit date: | 2014-09-18 | Release date: | 2015-07-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.944 Å) | Cite: | Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2. Nucleic Acids Res., 43, 2015
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4RD1
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![BU of 4rd1 by Molmil](/molmil-images/mine/4rd1) | Structure of aIF2-gamma H97A variant from Sulfolobus solfataricus bound to GTP | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Dubiez, E, Aleksandrov, A, Lazennec-Schurdevin, C, Mechulam, Y, Schmitt, E. | Deposit date: | 2014-09-18 | Release date: | 2015-05-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2. Nucleic Acids Res., 43, 2015
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4RD3
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![BU of 4rd3 by Molmil](/molmil-images/mine/4rd3) | Structure of aIF2-gamma H97A variant from Sulfolobus solfataricus bound to GDP and Pi | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Dubiez, E, Aleksandrov, A, Lazennec-Schurdevin, C, Mechulam, Y, Schmitt, E. | Deposit date: | 2014-09-18 | Release date: | 2015-05-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2. Nucleic Acids Res., 43, 2015
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6M1T
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![BU of 6m1t by Molmil](/molmil-images/mine/6m1t) | |
6Q6R
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![BU of 6q6r by Molmil](/molmil-images/mine/6q6r) | Recognition of different base tetrads by RHAU: X-ray crystal structure of G4 recognition motif bound to the 3-end tetrad of a DNA G-quadruplex | Descriptor: | ATP-dependent DNA/RNA helicase DHX36, POTASSIUM ION, Parallel stranded DNA G-quadruplex | Authors: | Heddi, B, Cheong, V.V, Schmitt, E, Mechulam, Y, Phan, A.T. | Deposit date: | 2018-12-11 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex. J.Struct.Biol., 209, 2020
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7DFY
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![BU of 7dfy by Molmil](/molmil-images/mine/7dfy) | Novel motif for left-handed G-quadruplex formation | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2xMotif2, POTASSIUM ION, ... | Authors: | Das, P, Winnerdy, F.R, Maity, A, Mechulam, Y, Phan, A.T. | Deposit date: | 2020-11-10 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | A novel minimal motif for left-handed G-quadruplex formation. Chem.Commun.(Camb.), 57, 2021
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5JB3
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![BU of 5jb3 by Molmil](/molmil-images/mine/5jb3) | Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-REMOTE conformation | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Coureux, P.-D, Schmitt, E, Mechulam, Y. | Deposit date: | 2016-04-13 | Release date: | 2016-11-30 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.34 Å) | Cite: | Cryo-EM study of start codon selection during archaeal translation initiation. Nat Commun, 7, 2016
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5JBH
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![BU of 5jbh by Molmil](/molmil-images/mine/5jbh) | Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN conformation | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein SX, 30S ribosomal protein eL41, ... | Authors: | Coureux, P.-D, Schmitt, E, Mechulam, Y. | Deposit date: | 2016-04-13 | Release date: | 2016-12-07 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (5.34 Å) | Cite: | Cryo-EM study of start codon selection during archaeal translation initiation. Nat Commun, 7, 2016
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7YZN
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![BU of 7yzn by Molmil](/molmil-images/mine/7yzn) | Structure of C-terminally truncated aIF5B from Pyrococcus abyssi complexed with GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable translation initiation factor IF-2, ... | Authors: | Bourgeois, G, Schmitt, E, Mechulam, Y, Coureux, P.D, Kazan, R. | Deposit date: | 2022-02-21 | Release date: | 2022-06-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Role of aIF5B in archaeal translation initiation. Nucleic Acids Res., 50, 2022
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6SPO
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![BU of 6spo by Molmil](/molmil-images/mine/6spo) | Structure of the Escherichia coli methionyl-tRNA synthetase complexed with methionine | Descriptor: | CITRIC ACID, GLYCEROL, METHIONINE, ... | Authors: | Nigro, G, Schmitt, E, Mechulam, Y. | Deposit date: | 2019-09-02 | Release date: | 2020-01-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J.Struct.Biol., 209, 2020
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5L4O
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![BU of 5l4o by Molmil](/molmil-images/mine/5l4o) | |
8BFW
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![BU of 8bfw by Molmil](/molmil-images/mine/8bfw) | The structures of Ace2 in complex with bicyclic peptide inhibitor | Descriptor: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-HIS-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | Authors: | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | Deposit date: | 2022-10-27 | Release date: | 2023-10-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2. J.Med.Chem., 66, 2023
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6SPQ
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![BU of 6spq by Molmil](/molmil-images/mine/6spq) | Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298 complexed with methionine | Descriptor: | CITRIC ACID, GLYCEROL, METHIONINE, ... | Authors: | Nigro, G, Schmitt, E, Mechulam, Y. | Deposit date: | 2019-09-02 | Release date: | 2020-01-01 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J.Struct.Biol., 209, 2020
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6SW9
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![BU of 6sw9 by Molmil](/molmil-images/mine/6sw9) | IC2A model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Coureux, P.-D, Mechulam, Y, Schmitt, E. | Deposit date: | 2019-09-20 | Release date: | 2020-02-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation. Commun Biol, 3, 2020
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5MLQ
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![BU of 5mlq by Molmil](/molmil-images/mine/5mlq) | Structure of CDPS from Nocardia brasiliensis | Descriptor: | CDPS, CITRIC ACID | Authors: | Bourgeois, G, Seguin, J, Moutiez, M, Babin, M, Belin, P, Mechulam, Y, Gondry, M, Schmitt, E. | Deposit date: | 2016-12-07 | Release date: | 2018-05-02 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Structural basis for partition of the cyclodipeptide synthases into two subfamilies. J.Struct.Biol., 203, 2018
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8BN1
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![BU of 8bn1 by Molmil](/molmil-images/mine/8bn1) | The structures of Ace2 in complex with bicyclic peptide inhibitor | Descriptor: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-4PH-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2, ... | Authors: | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | Deposit date: | 2022-11-11 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2. J.Med.Chem., 66, 2023
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8B9P
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![BU of 8b9p by Molmil](/molmil-images/mine/8b9p) | ACE2 in complex with bicyclic peptide inhibitor | Descriptor: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-GLY-ARG-GLN-PHE-CYS-HIS-THR-LEU-MET-PRO-ARG-HIS-LEU-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | Authors: | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | Deposit date: | 2022-10-06 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2. J.Med.Chem., 66, 2023
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