5A62
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![BU of 5a62 by Molmil](/molmil-images/mine/5a62) | Hydrolytic potential of the ammonia-oxidizing Thaumarchaeon Nitrososphaera gargenis - crystal structure and activity profiles of carboxylesterases linked to their metabolic function | Descriptor: | ACETATE ION, PUTATIVE ALPHA/BETA HYDROLASE FOLD PROTEIN | Authors: | Chow, J, Kaljunen, H, Nittinger, E, Spieck, E, Rarey, M, Mueller-Dieckmann, J, Streit, W.R. | Deposit date: | 2015-06-24 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Hydrolytic Potential of the Ammonia-Oxidizing Thaumarchaeon Nitrososphaera Gargenis - Crystal Structure and Activity Profiles of Carboxylesterases Linked to Their Metabolic Function To be Published
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4FBL
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![BU of 4fbl by Molmil](/molmil-images/mine/4fbl) | LipS and LipT, two metagenome-derived lipolytic enzymes increase the diversity of known lipase and esterase families | Descriptor: | CHLORIDE ION, LipS lipolytic enzyme, SPERMIDINE | Authors: | Chow, J, Krauss, U, Dall Antonia, Y, Fersini, F, Schmeisser, C, Schmidt, M, Menyes, I, Bornscheuer, U, Lauinger, B, Bongen, P, Pietruszka, J, Eckstein, M, Thum, O, Liese, A, Mueller-Dieckmann, J, Jaeger, K.-E, Kovacic, F, Streit, W.R, Structural Proteomics in Europe (SPINE) | Deposit date: | 2012-05-23 | Release date: | 2012-10-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The Metagenome-Derived Enzymes LipS and LipT Increase the Diversity of Known Lipases. Plos One, 7, 2012
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4FBM
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![BU of 4fbm by Molmil](/molmil-images/mine/4fbm) | LipS and LipT, two metagenome-derived lipolytic enzymes increase the diversity of known lipase and esterase families | Descriptor: | BROMIDE ION, LipS lipolytic enzyme | Authors: | Chow, J, Krauss, U, Dall Antonia, Y, Fersini, F, Schmeisser, C, Schmidt, M, Menyes, I, Bornscheuer, U, Lauinger, B, Bongen, P, Pietruszka, J, Eckstein, M, Thum, O, Liese, A, Mueller-Dieckmann, J, Jaeger, K.-E, Kovavic, F, Streit, W.R, Structural Proteomics in Europe (SPINE) | Deposit date: | 2012-05-23 | Release date: | 2012-10-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Metagenome-Derived Enzymes LipS and LipT Increase the Diversity of Known Lipases. Plos One, 7, 2012
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8VDW
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![BU of 8vdw by Molmil](/molmil-images/mine/8vdw) | |
8VCW
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![BU of 8vcw by Molmil](/molmil-images/mine/8vcw) | X-Ray Crystal Structure of the biotin synthase from B. obeum | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Biotin synthase, ... | Authors: | Lachowicz, J.C, Grove, T.L. | Deposit date: | 2023-12-14 | Release date: | 2024-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion. J.Am.Chem.Soc., 146, 2024
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3S4P
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![BU of 3s4p by Molmil](/molmil-images/mine/3s4p) | Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(2-phenylethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') | Authors: | Szychowski, J, Kondo, J, Zahr, O, Auclair, K, Westhof, E, Hanessian, S, Keillor, J.W. | Deposit date: | 2011-05-20 | Release date: | 2011-09-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues Chemmedchem, 6, 2011
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4H9V
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![BU of 4h9v by Molmil](/molmil-images/mine/4h9v) | Structure of Geobacillus kaustophilus lactonase, mutant E101G/R230C with Zn2+ | Descriptor: | FE (III) ION, HYDROXIDE ION, Phosphotriesterase, ... | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-25 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (1.971 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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4H9T
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![BU of 4h9t by Molmil](/molmil-images/mine/4h9t) | Structure of Geobacillus kaustophilus lactonase, mutant E101N with bound N-butyryl-DL-homoserine lactone | Descriptor: | FE (III) ION, MANGANESE (II) ION, N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide, ... | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-24 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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7PZJ
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![BU of 7pzj by Molmil](/molmil-images/mine/7pzj) | Structure of a bacteroidetal polyethylene terephthalate (PET) esterase | Descriptor: | Lipase, POTASSIUM ION | Authors: | Zang, H, Dierkes, R, Perez-Garcia, P, Weigert, S, Sternagel, S, Hallam, S.J, Applegate, V, Schumacher, J, Schott, T, Pleiss, J, Almeida, A, Hoecker, B, Smits, S.H, Schmitz, R.A, Chow, J, Streit, W.R. | Deposit date: | 2021-10-12 | Release date: | 2022-03-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity. Front Microbiol, 12, 2021
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3OJG
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![BU of 3ojg by Molmil](/molmil-images/mine/3ojg) | Structure of an inactive lactonase from Geobacillus kaustophilus with bound N-butyryl-DL-homoserine lactone | Descriptor: | FE (III) ION, N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide, Phosphotriesterase, ... | Authors: | Xue, B, Chow, J.Y, Tung, A, Robinson, R.C. | Deposit date: | 2010-08-22 | Release date: | 2010-10-27 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily J.Biol.Chem., 285, 2010
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4H9X
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![BU of 4h9x by Molmil](/molmil-images/mine/4h9x) | Structure of Geobacillus kaustophilus lactonase, mutant E101G/R230C/D266N with Zn2+ and bound N-butyryl-DL-homoserine lactone | Descriptor: | FE (III) ION, HYDROXIDE ION, N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide, ... | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-25 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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4H9Y
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![BU of 4h9y by Molmil](/molmil-images/mine/4h9y) | Structure of Geobacillus kaustophilus lactonase, mutant E101N with Zn2+ | Descriptor: | FE (III) ION, HYDROXIDE ION, Phosphotriesterase, ... | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-25 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (2.085 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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4HA0
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![BU of 4ha0 by Molmil](/molmil-images/mine/4ha0) | Structure of Geobacillus kaustophilus lactonase, mutant R230D with Zn2+ | Descriptor: | FE (III) ION, HYDROXIDE ION, Phosphotriesterase, ... | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-25 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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4H9U
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![BU of 4h9u by Molmil](/molmil-images/mine/4h9u) | Structure of Geobacillus kaustophilus lactonase, wild-type with Zn2+ | Descriptor: | FE (III) ION, HYDROXIDE ION, Phosphotriesterase, ... | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-25 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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4H9Z
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![BU of 4h9z by Molmil](/molmil-images/mine/4h9z) | Structure of Geobacillus kaustophilus lactonase, mutant E101N with Mn2+ | Descriptor: | FE (III) ION, MANGANESE (II) ION, Phosphotriesterase | Authors: | Xue, B, Chow, J.Y, Yew, W.S, Robinson, R.C. | Deposit date: | 2012-09-25 | Release date: | 2012-11-07 | Last modified: | 2013-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural evidence of a productive active site architecture for an evolved quorum-quenching GKL lactonase. Biochemistry, 52, 2013
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7N7I
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![BU of 7n7i by Molmil](/molmil-images/mine/7n7i) | X-ray crystal structure of Viperin-like enzyme from Trichoderma virens | Descriptor: | IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, URIDINE 5'-TRIPHOSPHATE, ... | Authors: | Grove, T.L, Almo, S.C, Bonanno, J.B, Lachowicz, J.C, Gizzi, A.G. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life. Biochemistry, 60, 2021
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7N7H
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![BU of 7n7h by Molmil](/molmil-images/mine/7n7h) | X-ray crystal structure of Viperin-like enzyme from Nematostella vectensis | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, ... | Authors: | Grove, T.L, Almo, S.C, Bonanno, J.B, Lachowicz, J.C, Gizzi, A.G. | Deposit date: | 2021-06-10 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life. Biochemistry, 60, 2021
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8VPO
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![BU of 8vpo by Molmil](/molmil-images/mine/8vpo) | X-Ray Crystal Structure of TigE from Paramaledivibacter caminithermalis | Descriptor: | GLYCEROL, IRON/SULFUR CLUSTER, Radical SAM core domain-containing protein | Authors: | Grove, T.L, Lachowicz, J.C, Zizola, C. | Deposit date: | 2024-01-16 | Release date: | 2024-02-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases. Acs Chem.Biol., 19, 2024
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2PUW
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![BU of 2puw by Molmil](/molmil-images/mine/2puw) | The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, CHLORIDE ION, isomerase domain of glutamine-fructose-6-phosphate transaminase (isomerizing) | Authors: | Raczynska, J, Olchowy, J, Milewski, S, Rypniewski, W. | Deposit date: | 2007-05-09 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.151 Å) | Cite: | The Crystal and Solution Studies of Glucosamine-6-phosphate Synthase from Candida albicans J.Mol.Biol., 372, 2007
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2PUV
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![BU of 2puv by Molmil](/molmil-images/mine/2puv) | The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans | Descriptor: | 5-AMINO-5-DEOXY-1-O-PHOSPHONO-D-MANNITOL, ACETATE ION, SODIUM ION, ... | Authors: | Raczynska, J, Olchowy, J, Milewski, S, Rypniewski, W. | Deposit date: | 2007-05-09 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Crystal and Solution Studies of Glucosamine-6-phosphate Synthase from Candida albicans J.Mol.Biol., 372, 2007
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2POC
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![BU of 2poc by Molmil](/molmil-images/mine/2poc) | The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, ACETATE ION, SODIUM ION, ... | Authors: | Raczynska, J, Olchowy, J, Milewski, S, Rypniewski, W. | Deposit date: | 2007-04-26 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal and Solution Studies of Glucosamine-6-phosphate Synthase from Candida albicans J.Mol.Biol., 372, 2007
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2PUT
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![BU of 2put by Molmil](/molmil-images/mine/2put) | The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans | Descriptor: | ACETATE ION, FRUCTOSE -6-PHOSPHATE, SODIUM ION, ... | Authors: | Raczynska, J, Olchowy, J, Milewski, S, Rypniewski, W. | Deposit date: | 2007-05-09 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Crystal and Solution Studies of Glucosamine-6-phosphate Synthase from Candida albicans J.Mol.Biol., 372, 2007
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3TTI
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![BU of 3tti by Molmil](/molmil-images/mine/3tti) | Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 10, trans-4-({9-[(3S)-tetrahydrofuran-3-yl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl}amino)cyclohexanol | Authors: | Plantevin-Krenitsky, V, Nadolny, L, Delgado, M, Ayala, L, Clareen, S, Hilgraf, R, Albers, R, Hegde, S, D'Sidocky, N, Sapienza, J, Wright, J, McCarrick, M, Bahmanyar, S, Chamberlain, P, Delker, S.L, Muir, J, Giegel, D, Xu, L, Celeridad, M, Lachowitzer, J, Bennett, B, Moghaddam, M, Khatsenko, O, Katz, J, Fan, R, Bai, A, Tang, Y, Shirley, M.A, Benish, B, Bodine, T, Blease, K, Raymon, H, Cathers, B.E, Satoh, Y. | Deposit date: | 2011-09-14 | Release date: | 2012-02-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg.Med.Chem.Lett., 22, 2012
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2PWT
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![BU of 2pwt by Molmil](/molmil-images/mine/2pwt) | Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group | Descriptor: | 22-mer of the ribosomal decoding site, DOUBLY FUNCTIONALIZED PAROMOMYCIN PM-II-162 | Authors: | Kondo, J, Pachamuthu, K, Francois, B, Szychowski, J, Hanessian, S, Westhof, E. | Deposit date: | 2007-05-13 | Release date: | 2007-09-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity Chemmedchem, 2, 2007
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