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PDB: 6 件
8TY1
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BU of 8ty1 by Molmil
Cryo-EM structure of coagulation factor VIII bound to NB2E9
分子名称: Coagulation factor VIII, NB2E9 heavy chain, NB2E9 light chain, ...
著者Childers, K.C, Spiegel, P.C.
登録日2023-08-24
公開日2023-09-13
最終更新日2024-09-25
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain.
J.Thromb.Haemost., 22, 2024
8G6I
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Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VIII chimera from human and pig, NB33 heavy chain, ...
著者Childers, K.C, Davulcu, O, Haynes, R.M, Lollar, P, Doering, C.B, Coxon, C.H, Spiegel, P.C.
登録日2023-02-15
公開日2023-05-24
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (4.23 Å)
主引用文献Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor.
Blood, 142, 2023
7K66
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Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2A9 heavy chain, ...
著者Childers, K.C, Gish, J, Jarvis, L, Peters, S, Garrels, C, Smith, I.W, Spencer, H.T, Spiegel, P.C.
登録日2020-09-18
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.92 Å)
主引用文献Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.
Blood, 137, 2021
9D5D
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Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A
分子名称: Factor VIIIa light chain
著者Avery, N.G, Childers, K.C, Spiegel, P.C.
登録日2024-08-13
公開日2024-09-04
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces
To Be Published
7S0P
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Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine
分子名称: Coagulation factor VIII, PHOSPHOSERINE
著者Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C.
登録日2021-08-30
公開日2021-10-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Front Mol Biosci, 9, 2022
7KBT
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Factor VIII in complex with the anti-C2 domain antibody, G99
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Ronayne, E.K, Gish, J, Wilson, C, Peters, S, Spencer, H.T, Spiegel, P.C, Childers, K.C.
登録日2020-10-02
公開日2020-11-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.15 Å)
主引用文献Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor
Front Immunol, 12, 2021

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件を2024-10-09に公開中

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