6A7E
 
 | | Human dihydrofolate reductase complexed with NADPH and BT2 | | Descriptor: | 5-(4-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Vanichtanankul, J, Tarnchompoo, B, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. | | Deposit date: | 2018-07-02 | | Release date: | 2019-04-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
ACS Med Chem Lett, 9, 2018
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6A7C
 | | Human dihydrofolate reductase complexed with NADPH and BT1 | | Descriptor: | 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Vanichtanankul, J, Tarnchompoo, B, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. | | Deposit date: | 2018-07-02 | | Release date: | 2019-04-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
ACS Med Chem Lett, 9, 2018
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5T76
 | | A fragment of a human tRNA synthetase | | Descriptor: | Alanine--tRNA ligase, cytoplasmic | | Authors: | Sun, L, Schimmel, P. | | Deposit date: | 2016-09-02 | | Release date: | 2016-11-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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6SQJ
 | | Crystal structure of glycoprotein D of Equine Herpesvirus Type 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein D, ... | | Authors: | Kremling, V, Loll, B, Azab, W, Osterrieder, N, Dahmani, I, Chiantia, P, Wahl, M. | | Deposit date: | 2019-09-04 | | Release date: | 2020-09-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.245 Å) | | Cite: | Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I.
Front Microbiol, 14, 2023
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6TM8
 | | Crystal structure of glycoprotein D of Equine Herpesvirus Type 4 | | Descriptor: | Envelope glycoprotein D, GLYCEROL | | Authors: | Kremling, V, Loll, B, Osterrieder, N, Wahl, M, Dahmani, I, Chiantia, P, Azab, W. | | Deposit date: | 2019-12-03 | | Release date: | 2020-11-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I.
Front Microbiol, 14, 2023
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2LW7
 | | NMR solution structure of human HisRS splice variant | | Descriptor: | Histidine--tRNA ligase, cytoplasmic | | Authors: | Ye, F, Wei, Z, Wu, J, Schimmel, P, Zhang, M. | | Deposit date: | 2012-07-24 | | Release date: | 2013-09-04 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of human HisRS splice variant
To be Published
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6UZV
 | | The structure of a red shifted photosystem I complex | | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | | Authors: | Toporik, H, Williams, D, Chiu, P.L, Mazor, Y. | | Deposit date: | 2019-11-15 | | Release date: | 2020-09-16 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The structure of a red-shifted photosystem I reveals a red site in the core antenna.
Nat Commun, 11, 2020
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7E8P
 | | Crystal structure of a Flavin-dependent Monooxygenase HadA wild type complexed with reduced FAD and 4-nitrophenol | | Descriptor: | Chlorophenol monooxygenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, P-NITROPHENOL | | Authors: | Pimviriyakul, P, Jaruwat, A, Chitnumsub, P, Chaiyen, P. | | Deposit date: | 2021-03-02 | | Release date: | 2021-07-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into a flavin-dependent dehalogenase HadA explain catalysis and substrate inhibition via quadruple pi-stacking.
J.Biol.Chem., 297, 2021
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7E8Q
 | | Crystal structure of a Flavin-dependent Monooxygenase HadA F441V mutant complexed with reduced FAD and 4-nitrophenol | | Descriptor: | Chlorophenol monooxygenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, P-NITROPHENOL | | Authors: | Pimviriyakul, P, Jaruwat, A, Chitnumsub, P, Chaiyen, P. | | Deposit date: | 2021-03-02 | | Release date: | 2021-07-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into a flavin-dependent dehalogenase HadA explain catalysis and substrate inhibition via quadruple pi-stacking.
J.Biol.Chem., 297, 2021
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5URF
 | | The structure of human bocavirus 1 | | Descriptor: | viral protein 3 | | Authors: | Mietzsch, M, Kailasan, S, Garrison, J, Ilyas, M, Chipman, P, Kandola, K, Jansen, M, Spear, J, Sousa, D, McKenna, R, Soderlund-Venermo, M, Baker, T, Agbandje-McKenna, M. | | Deposit date: | 2017-02-10 | | Release date: | 2017-03-29 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
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2N0C
 | | NMR structure of Neuromedin C in 10% TFE | | Descriptor: | Neuromedin C (NMC) | | Authors: | Adrover, M, Sanchis, P, Vilanova, B, Pauwels, K, Martorell, G, Perez, J. | | Deposit date: | 2015-03-05 | | Release date: | 2015-10-21 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism.
RSC ADV, 5, 2015
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2N0B
 | | NMR structure of Neuromedin C in aqueous solution | | Descriptor: | Neuromedin C (NMC) | | Authors: | Adrover, M, Sanchis, P, Vilanova, B, Pauwels, K, Martorell, G, Perez, J. | | Deposit date: | 2015-03-05 | | Release date: | 2015-10-14 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism.
RSC ADV, 5, 2015
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2N0F
 | | NMR structure of Neuromedin C in 60% TFE | | Descriptor: | Neuromedin C (NMC) | | Authors: | Adrover, M, Sanchis, P, Vilanova, B, Pauwels, K, Martorell, G, Perez, J. | | Deposit date: | 2015-03-05 | | Release date: | 2015-10-21 | | Last modified: | 2024-11-27 | | Method: | SOLUTION NMR | | Cite: | Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism.
RSC ADV, 5, 2015
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2N0G
 | | NMR structure of Neuromedin C in 90% TFE | | Descriptor: | Neuromedin C (NMC) | | Authors: | Adrover, M, Sanchis, P, Vilanova, B, Pauwels, K, Martorell, G, Perez, J. | | Deposit date: | 2015-03-05 | | Release date: | 2015-10-21 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism.
RSC ADV, 5, 2015
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6CBE
 | | Atomic structure of a rationally engineered gene delivery vector, AAV2.5 | | Descriptor: | Capsid protein VP1 | | Authors: | Burg, M, Rosebrough, C, Drouin, L, Bennett, A, Mietzsch, M, Chipman, P, McKenna, R, Sousa, D, Potter, M, Byrne, B, Kozyreva, O.G, Samulski, R.J, Agbandje-McKenna, M. | | Deposit date: | 2018-02-02 | | Release date: | 2018-05-30 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
J. Struct. Biol., 203, 2018
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1K4R
 | | Structure of Dengue Virus | | Descriptor: | MAJOR ENVELOPE PROTEIN E | | Authors: | Kuhn, R.J, Zhang, W, Rossmann, M.G, Pletnev, S.V, Corver, J, Lenches, E, Jones, C.T, Mukhopadhyay, S, Chipman, P.R, Strauss, E.G, Baker, T.S, Strauss, J.H. | | Deposit date: | 2001-10-08 | | Release date: | 2002-03-13 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (24 Å) | | Cite: | Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.
Cell(Cambridge,Mass.), 108, 2002
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1M0F
 | | Structural Studies of Bacteriophage alpha3 Assembly, Cryo-electron microscopy | | Descriptor: | Capsid Protein F, Major Spike Protein G, Scaffolding Protein B, ... | | Authors: | Bernal, R.A, Hafenstein, S, Olson, N.H, Bowman, V.D, Chipman, P.R, Baker, T.S, Fane, B.A, Rossmann, M.G. | | Deposit date: | 2002-06-12 | | Release date: | 2002-12-25 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (16 Å) | | Cite: | Structural Studies of Bacteriophage alpha3 Assembly
J.Mol.Biol., 325, 2003
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1N46
 | | CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC | | Descriptor: | Thyroid hormone receptor Beta-1, [4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PHENYL]-6-AZAURACIL | | Authors: | Dow, R.L, Schneider, S.R, Paight, E.S, Hank, R.F, Chiang, P, Cornelius, P, Lee, E, Newsome, W.P, Swick, A.G, Spitzer, J, Hargrove, D.M, Patterson, T.A, Pandit, J, Chrunyk, B.A, LeMotte, P.K, Danley, D.E, Rosner, M.H, Ammirati, M.J, Simons, S.P, Schulte, G.K, Tate, B.F, DaSilva-Jardine, P. | | Deposit date: | 2002-10-30 | | Release date: | 2003-04-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Discovery of a Novel Series of 6-Azauracil-Based Thyroid Hormone Receptor Ligands:
Potent, TRbeta Subtype-Selective Thyromimetics
Bioorg.Med.Chem.Lett., 13, 2003
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1NA4
 | | The structure of immature Yellow Fever virus particle | | Descriptor: | major envelope protein E | | Authors: | Zhang, Y, Corver, J, Chipman, P.R, Lenches, E, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G. | | Deposit date: | 2002-11-26 | | Release date: | 2003-12-09 | | Last modified: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (25 Å) | | Cite: | Structures of immature flavivirus particles
EMBO J., 22, 2003
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1N80
 | | Bacteriophage T4 baseplate structural protein gp8 | | Descriptor: | CHLORIDE ION, baseplate structural protein gp8 | | Authors: | Leiman, P.G, Shneider, M.M, Kostyuchenko, V.A, Chipman, P.R, Mesyanzhinov, V.V, Rossmann, M.G. | | Deposit date: | 2002-11-18 | | Release date: | 2003-06-10 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structure and location of gene product 8 in the bacteriophage T4 baseplate
J.Mol.Biol., 328, 2003
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1N6G
 | | The structure of immature Dengue-2 prM particles | | Descriptor: | major envelope protein E | | Authors: | Zhang, Y, Corver, J, Chipman, P.R, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G. | | Deposit date: | 2002-11-10 | | Release date: | 2003-06-03 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (16 Å) | | Cite: | Structures of Immature flavivirus particles
EMBO J., 22, 2003
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5T5S
 | | A fragment of a human tRNA synthetase | | Descriptor: | Alanine--tRNA ligase, cytoplasmic | | Authors: | Sun, L, Schimmel, P. | | Deposit date: | 2016-08-31 | | Release date: | 2016-11-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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1N7Z
 | | Structure and location of gene product 8 in the bacteriophage T4 baseplate | | Descriptor: | CHLORIDE ION, baseplate structural protein gp8 | | Authors: | Leiman, P.G, Shneider, M.M, Kostyuchenko, V.A, Chipman, P.R, Mesyanzhinov, V.V, Rossmann, M.G. | | Deposit date: | 2002-11-18 | | Release date: | 2003-06-10 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and location of gene product 8 in the bacteriophage T4 baseplate
J.Mol.Biol., 328, 2003
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3DGA
 | | Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide, ... | | Authors: | Dasgupta, T, Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Nichols, S, Lyons, T.M, Tirado-Rives, J, Jorgensen, W.L, Yuthavong, Y, Anderson, K.S. | | Deposit date: | 2008-06-13 | | Release date: | 2009-01-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
Acs Chem.Biol., 4, 2009
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1M06
 | | Structural Studies of Bacteriophage alpha3 Assembly, X-Ray Crystallography | | Descriptor: | 5'-D(P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR))-3', Capsid Protein, Major spike protein, ... | | Authors: | Bernal, R.A, Hafenstein, S, Olson, N.H, Bowman, V, Chipman, P.R, Baker, T.S, Fane, B.A, Rossmann, M.G. | | Deposit date: | 2002-06-12 | | Release date: | 2002-12-25 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural Studies of Bacteriophage alpha3 Assembly
J.Mol.Biol., 325, 2003
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