7A9I
 
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7A9J
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7RPU
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7RPT
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1AKE
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1E4Y
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8HTI
 | | Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein | | 分子名称: | Consensus Olfactory Receptor OR52c, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | | 登録日 | 2022-12-21 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
Nat Commun, 14, 2023
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9C0Y
 | | Clathrin terminal domain complexed with Pitstop 2c | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... | | 著者 | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | | 登録日 | 2024-05-28 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
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9C0Z
 | | Clathrin terminal domain complexed with pitstop 2d | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | | 著者 | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | | 登録日 | 2024-05-28 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
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8W77
 | | Human Consensus Olfactory Receptor OR52c in apo state, OR52c only | | 分子名称: | Human Consensus Olfactory Receptor OR52c in apo state, receptor only,Soluble cytochrome b562 | | 著者 | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | | 登録日 | 2023-08-30 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
Nat Commun, 14, 2023
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2AAD
 | | THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT | | 分子名称: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 ISOZYME | | 著者 | Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. | | 登録日 | 1992-09-15 | | 公開日 | 1994-01-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant.
Biochemistry, 31, 1992
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2AAE
 | | THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT | | 分子名称: | CALCIUM ION, PHOSPHATE ION, RIBONUCLEASE T1 | | 著者 | Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. | | 登録日 | 1992-09-15 | | 公開日 | 1994-01-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant.
Biochemistry, 31, 1992
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4Z44
 | | F454K Mutant of Tryptophan 7-halogenase PrnA | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Flavin-dependent tryptophan halogenase PrnA, ... | | 著者 | Shepherd, S.A, Karthikeyan, C, Latham, J, Struck, A.-W, Thompson, M.L, Menon, B, Levy, C.W, Leys, D, Micklefield, J. | | 登録日 | 2015-04-01 | | 公開日 | 2016-04-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.204 Å) | | 主引用文献 | Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes.
Chem Sci, 6, 2015
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4YXP
 | | The structure of the folded domain of the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer. | | 分子名称: | ZINC ION, mRNA export factor | | 著者 | Tunnicliffe, R.B, Schacht, M, Levy, C.W, Jowitt, T.A, Sandri-Goldin, R.M, Golovanov, A.P. | | 登録日 | 2015-03-23 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.
Sci Rep, 5, 2015
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4Z43
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8RA0
 | | Crystal structure of CysF | | 分子名称: | AMP-dependent synthetase, CITRATE ANION, TETRAETHYLENE GLYCOL | | 著者 | Levy, C.W. | | 登録日 | 2023-11-30 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Cryptic enzymatic assembly of peptides armed with beta-lactone warheads.
Nat.Chem.Biol., 2024
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6Z1L
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6Z1K
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4KVR
 | | Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant V41Y) | | 分子名称: | Aldehyde decarbonylase, FE (III) ION, HEXANOIC ACID | | 著者 | Levy, C.W, Khara, B, Menon, N, Mansell, D, Das, D, Marsh, E.N.G, Leys, D, Scrutton, N.S. | | 登録日 | 2013-05-23 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase.
Chembiochem, 14, 2013
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4KVS
 | | Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant A134F) | | 分子名称: | Aldehyde decarbonylase, FE (III) ION, HEXANOIC ACID | | 著者 | Levy, C.W, Khara, B, Menon, N, Mansell, D, Das, D, Marsh, E.N.G, Leys, D, Scrutton, N.S. | | 登録日 | 2013-05-23 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase.
Chembiochem, 14, 2013
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5GPG
 | | Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR | | 著者 | Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W. | | 登録日 | 2016-08-02 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Acs Cent.Sci., 2, 2016
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3KOW
 | | Crystal Structure of ornithine 4,5 aminomutase backsoaked complex | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2012-10-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3K8D
 | | Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase in complex with CTP and 2-deoxy-Kdo | | 分子名称: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, 3-deoxy-manno-octulosonate cytidylyltransferase, CYTIDINE-5'-TRIPHOSPHATE, ... | | 著者 | Heyes, D.J, Levy, C.W, Lafite, P, Scrutton, N.S, Leys, D. | | 登録日 | 2009-10-14 | | 公開日 | 2009-11-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases
J.Biol.Chem., 284, 2009
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3K8E
 | | Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase | | 分子名称: | 3-deoxy-manno-octulosonate cytidylyltransferase | | 著者 | Heyes, D.J, Levy, C.W, Lafite, P, Scrutton, N.S, Leys, D. | | 登録日 | 2009-10-14 | | 公開日 | 2009-11-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases
J.Biol.Chem., 284, 2009
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3KOZ
 | | Crystal Structure of ornithine 4,5 aminomutase in complex with ornithine (Anaerobic) | | 分子名称: | (E)-N~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-ornithine, 5'-DEOXYADENOSINE, COBALAMIN, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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