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PDB: 157 件

6TTV
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BU of 6ttv by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 3 (ASI_M3M_138)
分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
6TTW
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BU of 6ttw by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 4 (ASI_M3M_047)
分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-piperidin-4-yl-oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
6TTT
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BU of 6ttt by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 2 (ASI_M3M_140)
分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
6YOQ
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BU of 6yoq by Molmil
Crystal structure of YTHDC1 with compound VVR_DC1_002
分子名称: 6-methyl-~{N}-[2-(methylsulfonylamino)ethyl]-2-oxidanylidene-3~{H}-pyridine-3-carboxamide, SULFATE ION, YTHDC1
著者von Roten, V, Bedi, R.K, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6SW3
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BU of 6sw3 by Molmil
Crystal structure of CREBBP bromodomain L1109W mutant
分子名称: cDNA FLJ57039, highly similar to CREB-binding protein
著者Faessler, C, Bedi, R.K, Wiedmer, L, Caflisch, A.
登録日2019-09-19
公開日2019-10-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of CREBBP bromodomain L1109W mutant
To Be Published
6SXX
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BU of 6sxx by Molmil
Crystal structure of the bromodomain of human CREBBP in complex with ACA007
分子名称: (3~{R})-1-ethanoylpyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, CREBBP
著者Xiang, W, Bedi, R.K, Sledz, P, Caflisch, A.
登録日2019-09-26
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure of the bromodomain of human CREBBP in complex with ACA007
To Be Published
7OGJ
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BU of 7ogj by Molmil
Crystal structure of human METTL1 in complex with SAH
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Nai, F, Bedi, R.K, Caflisch, A.
登録日2021-05-06
公開日2021-05-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Small-Molecule Inhibitors of the m7G-RNA Writer METTL1
Acs Bio Med Chem Au, 2023

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件を2024-10-30に公開中

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