3GIF
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![BU of 3gif by Molmil](/molmil-images/mine/3gif) | Crystal structure of DesKC_H188E in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Sensor histidine kinase desK | Authors: | Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. | Deposit date: | 2009-03-05 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
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1RAL
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![BU of 1ral by Molmil](/molmil-images/mine/1ral) | THREE-DIMENSIONAL STRUCTURE OF RAT LIVER 3ALPHA-HYDROXYSTEROID(SLASH)DIHYDRODIOL DEHYDROGENASE: A MEMBER OF THE ALDO-KETO REDUCTASE SUPERFAMILY | Descriptor: | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Authors: | Hoog, S.S, Pawlowski, J.E, Alzari, P.M, Penning, T.M, Lewis, M. | Deposit date: | 1994-02-04 | Release date: | 1994-04-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc.Natl.Acad.Sci.USA, 91, 1994
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5M06
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![BU of 5m06 by Molmil](/molmil-images/mine/5m06) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Serine/threonine-protein kinase PknI | Authors: | Wagner, T, Lisa, M.N, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2016-10-03 | Release date: | 2017-01-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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1B7B
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![BU of 1b7b by Molmil](/molmil-images/mine/1b7b) | Carbamate kinase from Enterococcus faecalis | Descriptor: | CARBAMATE KINASE, SULFATE ION | Authors: | Marina, A, Alzari, P.M, Bravo, J, Uriarte, M, Barcelona, B, Fita, I, Rubio, V. | Deposit date: | 1999-01-20 | Release date: | 2000-01-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine. Protein Sci., 8, 1999
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3GIE
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![BU of 3gie by Molmil](/molmil-images/mine/3gie) | Crystal structure of DesKC_H188E in complex with AMP-PCP | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor histidine kinase desK | Authors: | Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. | Deposit date: | 2009-03-05 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
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1N47
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![BU of 1n47 by Molmil](/molmil-images/mine/1n47) | Isolectin B4 from Vicia villosa in complex with the Tn antigen | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, CALCIUM ION, Isolectin B4, ... | Authors: | Babino, A, Tello, D, Rojas, A, Bay, S, Osinaga, E, Alzari, P.M. | Deposit date: | 2002-10-30 | Release date: | 2003-02-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of a plant lectin in complex with the Tn antigen FEBS Lett., 536, 2003
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2WZV
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![BU of 2wzv by Molmil](/molmil-images/mine/2wzv) | Crystal structure of the FMN-dependent nitroreductase NfnB from Mycobacterium smegmatis | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, NFNB PROTEIN, ... | Authors: | Bellinzoni, M, Manina, G, Riccardi, G, Alzari, P.M. | Deposit date: | 2009-12-03 | Release date: | 2010-07-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Biological and Structural Characterization of the Mycobacterium Smegmatis Nitroreductase Nfnb, and its Role in Benzothiazinone Resistance Mol.Microbiol., 77, 2010
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1HHP
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![BU of 1hhp by Molmil](/molmil-images/mine/1hhp) | |
2WZW
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![BU of 2wzw by Molmil](/molmil-images/mine/2wzw) | Crystal structure of the FMN-dependent nitroreductase NfnB from Mycobacterium smegmatis in complex with NADPH | Descriptor: | FLAVIN MONONUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NFNB PROTEIN, ... | Authors: | Bellinzoni, M, Manina, G, Riccardi, G, Alzari, P.M. | Deposit date: | 2009-12-03 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Biological and Structural Characterization of the Mycobacterium Smegmatis Nitroreductase Nfnb, and its Role in Benzothiazinone Resistance Mol.Microbiol., 77, 2010
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2FHR
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![BU of 2fhr by Molmil](/molmil-images/mine/2fhr) | Trypanosoma Rangeli Sialidase In Complex With 2,3- Difluorosialic Acid (Covalent Intermediate) | Descriptor: | 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, GLYCEROL, SULFATE ION, ... | Authors: | Amaya, M.F, Alzari, P.M, Buschiazzo, A. | Deposit date: | 2005-12-26 | Release date: | 2006-01-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase. J.Biol.Chem., 281, 2006
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4CJ2
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![BU of 4cj2 by Molmil](/molmil-images/mine/4cj2) | Crystal structure of HEWL in complex with affitin H4 | Descriptor: | AFFITIN H4, GLYCEROL, LYSOZYME C | Authors: | Correa, A, Pacheco, S, Mechaly, A.E, Obal, G, Behar, G, Mouratou, B, Oppezzo, P, Alzari, P.M, Pecorari, F. | Deposit date: | 2013-12-18 | Release date: | 2014-05-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins) Plos One, 9, 2014
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4CJ1
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![BU of 4cj1 by Molmil](/molmil-images/mine/4cj1) | Crystal structure of CelD in complex with affitin H3 | Descriptor: | CALCIUM ION, ENDOGLUCANASE D, GLYCEROL, ... | Authors: | Correa, A, Pacheco, S, Mechaly, A.E, Obal, G, Behar, G, Mouratou, B, Oppezzo, P, Alzari, P.M, Pecorari, F. | Deposit date: | 2013-12-18 | Release date: | 2014-05-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins) Plos One, 9, 2014
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4CJ0
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![BU of 4cj0 by Molmil](/molmil-images/mine/4cj0) | Crystal structure of CelD in complex with affitin E12 | Descriptor: | CALCIUM ION, E12 AFFITIN, ENDOGLUCANASE D, ... | Authors: | Correa, A, Pacheco, S, Mechaly, A.E, Obal, G, Behar, G, Mouratou, B, Oppezzo, P, Alzari, P.M, Pecorari, F. | Deposit date: | 2013-12-18 | Release date: | 2014-05-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins) Plos One, 9, 2014
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1N1Y
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![BU of 1n1y by Molmil](/molmil-images/mine/1n1y) | Trypanosoma rangeli sialidase in complex with sialic acid | Descriptor: | N-acetyl-alpha-neuraminic acid, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-21 | Release date: | 2003-01-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The high resolution structures of free and inhibitor-bound
Trypanosoma rangeli sialidase and its comparison with T.
cruzi trans-sialidase J.Mol.Biol., 325, 2003
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1N1T
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![BU of 1n1t by Molmil](/molmil-images/mine/1n1t) | Trypanosoma rangeli sialidase in complex with DANA at 1.6 A | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-20 | Release date: | 2003-01-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T. cruzi
trans-sialidase J.Mol.Biol., 325, 2003
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1N1V
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![BU of 1n1v by Molmil](/molmil-images/mine/1n1v) | Trypanosoma rangeli sialidase in complex with DANA | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-21 | Release date: | 2003-01-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T.
cruzi trans-sialidase J.Mol.Biol., 325, 2003
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1N1S
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![BU of 1n1s by Molmil](/molmil-images/mine/1n1s) | Trypanosoma rangeli sialidase | Descriptor: | SULFATE ION, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-20 | Release date: | 2003-01-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T. cruzi
trans-sialidase J.Mol.Biol., 325, 2003
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2CE3
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![BU of 2ce3 by Molmil](/molmil-images/mine/2ce3) | CRYSTAL STRUCTURE OF THE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 (CLPP1) FROM MYCOBACTERIUM TUBERCULOSIS | Descriptor: | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 | Authors: | Segelke, B, Kim, C.Y, Ortiz-Lombardia, M, Alzari, P.M, Lekin, T. | Deposit date: | 2006-02-03 | Release date: | 2006-02-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights Into the Inter-Ring Plasticity of Caseinolytic Proteases from the X-Ray Structure of Mycobacterium Tuberculosis Clpp1. Acta Crystallogr.,Sect.D, 63, 2007
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2V57
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![BU of 2v57 by Molmil](/molmil-images/mine/2v57) | Crystal structure of the TetR-like transcriptional regulator LfrR from Mycobacterium smegmatis in complex with proflavine | Descriptor: | ISOPROPYL ALCOHOL, PROFLAVIN, SULFATE ION, ... | Authors: | Bellinzoni, M, Buroni, S, Riccardi, G, De Rossi, E, Alzari, P.M. | Deposit date: | 2008-10-02 | Release date: | 2009-10-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Plasticity and Distinct Drug-Binding Modes of Lfrr, a Mycobacterial Efflux Pump Regulator. J.Bacteriol., 191, 2009
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4APB
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![BU of 4apb by Molmil](/molmil-images/mine/4apb) | Crystal structure of Mycobacterium tuberculosis fumarase (Rv1098c) S318C in complex with fumarate | Descriptor: | CALCIUM ION, FUMARATE HYDRATASE CLASS II, FUMARIC ACID | Authors: | Bellinzoni, M, Haouz, A, Mechaly, A.E, Alzari, P.M. | Deposit date: | 2012-03-31 | Release date: | 2012-04-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis. FEBS Lett., 586, 2012
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4A12
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![BU of 4a12 by Molmil](/molmil-images/mine/4a12) | Structure of the global transcription regulator FapR from Staphylococcus aureus in complex with DNA operator | Descriptor: | FAPR PROMOTER, TRANSCRIPTION FACTOR FAPR | Authors: | Albanesi, D, Guerin, M.E, Buschiazzo, A, de Mendoza, D, Alzari, P.M. | Deposit date: | 2011-09-13 | Release date: | 2012-09-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus Aureus. Plos Pathog., 9, 2013
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4BIZ
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![BU of 4biz by Molmil](/molmil-images/mine/4biz) | |
4ADL
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![BU of 4adl by Molmil](/molmil-images/mine/4adl) | Crystal structures of Rv1098c in complex with malate | Descriptor: | (2S)-2-hydroxybutanedioic acid, FUMARATE HYDRATASE CLASS II | Authors: | Mechaly, A.E, Haouz, A, Miras, I, Weber, P, Shepard, W, Cole, S, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2011-12-26 | Release date: | 2012-04-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis. FEBS Lett., 586, 2012
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4ADM
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![BU of 4adm by Molmil](/molmil-images/mine/4adm) | Crystal structure of Rv1098c in complex with meso-tartrate | Descriptor: | FUMARATE HYDRATASE CLASS II, GLYCEROL, S,R MESO-TARTARIC ACID | Authors: | Mechaly, A.E, Haouz, A, Miras, I, Weber, P, Shepard, W, Cole, S, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2011-12-27 | Release date: | 2012-04-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis. FEBS Lett., 586, 2012
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3ZHR
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![BU of 3zhr by Molmil](/molmil-images/mine/3zhr) | Crystal structure of the H747A mutant of the SucA domain of Mycobacterium smegmatis KGD showing the active site lid closed | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Wagner, T, Barilone, N, Bellinzoni, M, Alzari, P.M. | Deposit date: | 2012-12-24 | Release date: | 2013-11-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Dual Conformation of the Post-Decarboxylation Intermediate is Associated with Distinct Enzyme States in Mycobacterial Alpha-Ketoglutarate Decarboxylase (Kgd). Biochem.J., 457, 2014
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