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PDB: 227 件
2CM8
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Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
分子名称: 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, MAGNESIUM ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
著者Ala, P.J, Gonneville, L, Hillman, M.C, Becker-Pasha, M, Wei, M, Reid, B.G, Klabe, R, Yue, E.W, Wayland, B, Douty, B, Combs, A.P, Polam, P, Wasserman, Z, Bower, M, Burn, T.C, Hollis, G.F, Wynn, R.
登録日2006-05-04
公開日2006-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CNG
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Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
分子名称: GLYCEROL, MAGNESIUM ION, N-{(1S)-2-{4-[(5R)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[5-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOL-2-YL]ETHYL}-2,2,2-TRIFLUOROACETAMIDE, ...
著者Ala, P.J, Gonneville, L, Hillman, M, Becker-Pasha, M, Yue, E.W, Douty, B, Wayland, B, Polam, P, Crawley, M.L, McLaughlin, E, Sparks, R.B, Glass, B, Takvorian, A, Combs, A.P, Burn, T.C, Hollis, G.F, Wynn, R.
登録日2006-05-21
公開日2006-09-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
1QBT
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HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
分子名称: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE]
著者Ala, P, Chang, C.-H.
登録日1997-04-25
公開日1997-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997
1QBU
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HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
分子名称: HIV-1 PROTEASE, [4R--(1ALPHA,5ALPHA,7BETA)]-3-[(CYCLOPROPHYLMETHYL)HEXAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPIN] METHYL-2-THIAZOLYLBENZAMIDE
著者Ala, P, Chang, C.-H.
登録日1997-04-25
公開日1997-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997
2CM2
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BU of 2cm2 by Molmil
Structure of Protein Tyrosine Phosphatase 1B (P212121)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
著者Ala, P.J, Gonneville, L, Hillman, M.C, Becker-Pasha, M, Wei, M, Reid, B.G, Klabe, R, Yue, E.W, Wayland, B, Douty, B, Combs, A.P, Polam, P, Wasserman, Z, Bower, M, Burn, T.C, Hollis, G.F, Wynn, R.
登録日2006-05-04
公開日2006-08-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CM3
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Structure of Protein Tyrosine Phosphatase 1B (C2)
分子名称: CALCIUM ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
著者Ala, P.J, Gonneville, L, Hillman, M.C, Becker-Pasha, M, Wei, M, Reid, B.G, Klabe, R, Yue, E.W, Wayland, B, Douty, B, Combs, A.P, Polam, P, Wasserman, Z, Bower, M, Burn, T.C, Hollis, G.F, Wynn, R.
登録日2006-05-04
公開日2006-08-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for Inhibition of Protein-Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics.
J.Biol.Chem., 281, 2006
2CNH
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Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B
分子名称: CALCIUM ION, N-[(1S)-1-(1H-BENZIMIDAZOL-2-YL)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}ETHYL]-4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-SULFONAMIDE, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
著者Ala, P.J, Gonneville, L, Hillman, M, Becker-Pasha, M, Yue, E.W, Douty, B, Wayland, B, Polam, P, Crawley, M.L, McLaughlin, E, Sparks, R.B, Glass, B, Takvorian, A, Combs, A.P, Burn, T.C, Hollis, G.F, Wynn, R.
登録日2006-05-21
公開日2006-09-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B.
J.Biol.Chem., 281, 2006
4EL8
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BU of 4el8 by Molmil
The unliganded structure of C.bescii CelA GH48 module
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Glycoside hydrolase family 48, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2012-04-10
公開日2013-03-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Revealing nature's cellulase diversity: the digestion mechanism of Caldicellulosiruptor bescii CelA.
Science, 342, 2013
1QBS
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BU of 1qbs by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
分子名称: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE
著者Ala, P, Chang, C.-H.
登録日1997-04-25
公開日1997-10-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
J.Med.Chem., 39, 1996
5O44
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Crystal structure of unbranched mixed tri-Ubiquitin chain containing K48 and K63 linkages.
分子名称: MAGNESIUM ION, Polyubiquitin-B, SULFATE ION, ...
著者Padala, P, Isupov, M.N, Wiener, R.
登録日2017-05-26
公開日2017-11-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages.
J. Mol. Biol., 429, 2017
6N2C
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BU of 6n2c by Molmil
The Crystal Structure of Caldicellulosiruptor hydrothermalis Tapirin C-terminal domain
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2018-11-12
公開日2018-12-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Comparative Biochemical and Structural Analysis of Novel Cellulose Binding Proteins (Tapirins) from Extremely ThermophilicCaldicellulosiruptorSpecies.
Appl. Environ. Microbiol., 85, 2019
6N2B
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The Crystal Structure of Caldicellulosiruptor kristjanssonii Tapirin C-terminal domain
分子名称: CALCIUM ION, GLYCEROL, Tapirin
著者Alahuhta, P.M, Lunin, V.V.
登録日2018-11-12
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Comparative Biochemical and Structural Analysis of Novel Cellulose Binding Proteins (Tapirins) from Extremely ThermophilicCaldicellulosiruptorSpecies.
Appl. Environ. Microbiol., 85, 2019
6VSP
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BU of 6vsp by Molmil
Structure of Serratia marcescens 2,3-butanediol dehydrogenase mutant Q247A
分子名称: 1,2-ETHANEDIOL, 2,3-butanediol dehydrogenase, ADENOSINE-5'-DIPHOSPHATE, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2020-02-11
公開日2020-12-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Phylogenetics-based identification and characterization of a superior 2,3-butanediol dehydrogenase for Zymomonas mobilis expression.
Biotechnol Biofuels, 13, 2020
6D5C
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Structure of Caldicellulosiruptor danielii GH10 module of glycoside hydrolase WP_045175321
分子名称: 1,2-ETHANEDIOL, FORMIC ACID, GLYCEROL, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2018-04-19
公開日2019-04-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Novel multidomain, multifunctional glycoside hydrolases from highly lignocellulolytic Caldicellulosiruptor species
AIChE J., 2019
5O36
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Japanese encephalitis virus non-structural protein 1' C-terminal domain
分子名称: Japanese encephalitis virus non-structural protein 1' (NS1'),Japanese encephalitis virus non-structural protein 1' (NS1'), N-PROPANOL, SULFATE ION
著者Thanalai, P, Wright, G.S.A, Antonyuk, S.V.
登録日2017-05-23
公開日2018-01-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus.
J. Virol., 92, 2018
6CCI
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BU of 6cci by Molmil
The Crystal Structure of XOAT1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2018-02-07
公開日2019-02-20
最終更新日2020-09-02
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Molecular Mechanism of Polysaccharide Acetylation by the Arabidopsis XylanO-acetyltransferase XOAT1.
Plant Cell, 32, 2020
3F27
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Structure of Sox17 Bound to DNA
分子名称: DNA (5'-D(*DCP*DCP*DAP*DGP*DGP*DAP*DCP*DAP*DAP*DTP*DAP*DGP*DAP*DGP*DAP*DC)-3'), DNA (5'-D(*DGP*DTP*DCP*DTP*DCP*DTP*DAP*DTP*DTP*DGP*DTP*DCP*DCP*DTP*DGP*DG)-3'), Transcription factor SOX-17
著者Palasingam, P, Jauch, R, Ng, C.K.L, Kolatkar, P.R.
登録日2008-10-29
公開日2009-04-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The Structure of Sox17 Bound to DNA Reveals a Conserved Bending Topology but Selective Protein Interaction Platforms
J.Mol.Biol., 388, 2009
2KHJ
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BU of 2khj by Molmil
NMR structure of the domain 6 of the E. coli ribosomal protein S1
分子名称: 30S ribosomal protein S1
著者Salah, P, Bisaglia, M, Aliprandi, P, Uzan, M, Sizun, C, Bontems, F.
登録日2009-04-07
公開日2009-10-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Probing the relationship between Gram-negative and Gram-positive S1 proteins by sequence analysis
Nucleic Acids Res., 37, 2009
2KHI
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BU of 2khi by Molmil
NMR structure of the domain 4 of the E. coli ribosomal protein S1
分子名称: 30S ribosomal protein S1
著者Salah, P, Bisaglia, M, Aliprandi, P, Uzan, M, Sizun, C, Bontems, F.
登録日2009-04-07
公開日2009-10-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Probing the relationship between Gram-negative and Gram-positive S1 proteins by sequence analysis
Nucleic Acids Res., 37, 2009
6XEX
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BU of 6xex by Molmil
Structure of Serratia marcescens 2,3-butanediol dehydrogenase mutant Q247A/V139Q
分子名称: 1,2-ETHANEDIOL, 2,3-butanediol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2020-06-14
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Phylogenetics-based identification and characterization of a superior 2,3-butanediol dehydrogenase for Zymomonas mobilis expression.
Biotechnol Biofuels, 13, 2020
6XEW
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Structure of Serratia marcescens 2,3-butanediol dehydrogenase
分子名称: 2,3-butanediol dehydrogenase, ADENOSINE-5'-DIPHOSPHATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2020-06-14
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Phylogenetics-based identification and characterization of a superior 2,3-butanediol dehydrogenase for Zymomonas mobilis expression.
Biotechnol Biofuels, 13, 2020
5IA7
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Crystal structure of Ubiquitin fold modifier 1 (Ufm1)
分子名称: Ubiquitin-fold modifier 1
著者Padala, P, Oweis, W, Wiener, R.
登録日2016-02-21
公開日2017-03-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence.
Sci Rep, 7, 2017
4XEB
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The structure of P. funicolosum Cel7A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glucanase, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2014-12-23
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Engineering enhanced cellobiohydrolase activity
Nat Commun, 9(1), 2018
5ECU
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The unliganded structure of Caldicellulosiruptor saccharolyticus GH5
分子名称: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2015-10-20
公開日2016-11-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The structure of Caldicellulosiruptor saccharolyticus GH5
To Be Published
5KWK
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The structure of Arabidopsis thaliana FUT1 in complex with GDP
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
著者Alahuhta, P.M, Lunin, V.V.
登録日2016-07-18
公開日2016-09-28
最終更新日2018-05-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural, mutagenic and in silico studies of xyloglucan fucosylation in Arabidopsis thaliana suggest a water-mediated mechanism.
Plant J., 91, 2017

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