9H3S
 
 | | 50S subunit precursor C-CP_YjgA_L22 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, 5S ribosomal RNA, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-10-17 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HA5
 | | Pooled 50S subunit C_L2 precursor states supplemented with Api137 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Apidaecins type 22, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-01 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HAI
 | | Pooled 50S subunit C-CP_L2-L28 precursor states supplemented with Api137 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Apidaecins type 22, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-04 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HAL
 | | Pooled 50S subunit d126_(L29)-/(L22)- precursor states supplemented with Api137 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Large ribosomal subunit protein bL17, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-04 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (4.49 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HA6
 | | mature 50S subunit supplemented with Api137 | | Descriptor: | 23S ribosomal rRNA, 50S ribosomal protein L16, 50S ribosomal protein L3, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-01 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9H3K
 | | 50S subunit precursor d126_(L29)-/(L22)- | | Descriptor: | 23S ribosomal RNA, Large ribosomal subunit protein bL17, Large ribosomal subunit protein bL20, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-10-17 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (6.62 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9H3Z
 | | mature 50S subunit | | Descriptor: | 23S ribosomal rRNA, 50S ribosomal protein L16, 50S ribosomal protein L3, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-10-17 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9H3M
 | | 50S subunit precursor C_(L22)- | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Large ribosomal subunit protein bL17, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-10-17 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (4.41 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HA1
 | | Pooled 50S subunit C_(L22)- precursor states supplemented with Api137 - Canonical PET exit Api137 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Apidaecins type 137, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-01 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HAM
 | | C_(L29)-/(L22)- precursor supplemented with Api137 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Large ribosomal subunit protein bL17, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-04 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (5.06 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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4V68
 | | T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map. | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Schuette, J.-C, Spahn, C.M.T. | | Deposit date: | 2008-12-11 | | Release date: | 2014-07-09 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | GTPase activation of elongation factor EF-Tu by the ribosome during decoding
Embo J., 28, 2009
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6YGB
 | | Crystal structure of the NatC complex bound to CoA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COENZYME A, ... | | Authors: | Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O. | | Deposit date: | 2020-03-27 | | Release date: | 2020-10-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.451 Å) | | Cite: | Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Nat Commun, 11, 2020
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6YGA
 | | Crystal structure of the apo NatC complex | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O. | | Deposit date: | 2020-03-27 | | Release date: | 2020-10-28 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.397 Å) | | Cite: | Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Nat Commun, 11, 2020
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6YGD
 | | Crystal structure of the NatC complex bound to Gag peptide and CoA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COENZYME A, ... | | Authors: | Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O. | | Deposit date: | 2020-03-27 | | Release date: | 2020-10-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.752 Å) | | Cite: | Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Nat Commun, 11, 2020
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1HLY
 | | SOLUTION STRUCTURE OF HONGOTOXIN 1 | | Descriptor: | HONGOTOXIN 1 | | Authors: | Pragl, B, Koschak, A, Trieb, M, Obermair, G, Kaufmann, W.A, Gerster, U, Blanc, E, Hahn, C, Prinz, H, Schutz, G, Darbon, H, Gruber, H.J, Knaus, H.G. | | Deposit date: | 2000-12-04 | | Release date: | 2003-09-30 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The
first high affinity fluorescence probes for voltage-gated K+ channels.
BIOCONJUG.CHEM., 13, 2002
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6GZ4
 | | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | | Deposit date: | 2018-07-03 | | Release date: | 2018-12-05 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.
Cell Rep, 25, 2018
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6GOV
 | | Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX | | Descriptor: | 30S ribosomal protein S10, Antitermination protein N, DNA (I), ... | | Authors: | Loll, B, Krupp, F, Said, N, Huang, Y, Buerger, J, Mielke, T, Spahn, C.M.T, Wahl, M.C. | | Deposit date: | 2018-06-04 | | Release date: | 2019-02-13 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor.
Mol.Cell, 74, 2019
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2ORV
 | | human Thymidine Kinase 1 in complex with TP4A | | Descriptor: | P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ZINC ION | | Authors: | Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A. | | Deposit date: | 2007-02-04 | | Release date: | 2007-03-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
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7ZNN
 | | Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 | | Descriptor: | B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... | | Authors: | Lauer, S, Spahn, C.M.T, Schwefel, D. | | Deposit date: | 2022-04-21 | | Release date: | 2022-11-09 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
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5M1J
 | | Nonstop ribosomal complex bound with Dom34 and Hbs1 | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Hilal, T, Yamamoto, H, Loerke, J, Buerger, J, Mielke, T, Spahn, C.M.T. | | Deposit date: | 2016-10-07 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution.
Nat Commun, 7, 2016
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7ZN7
 | | Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD | | Descriptor: | B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... | | Authors: | Lauer, S, Spahn, C.M.T, Schwefel, D. | | Deposit date: | 2022-04-20 | | Release date: | 2022-11-09 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
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2ORW
 | | Thermotoga maritima thymidine kinase 1 like enzyme in complex with TP4A | | Descriptor: | MAGNESIUM ION, P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ... | | Authors: | Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A. | | Deposit date: | 2007-02-04 | | Release date: | 2007-03-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
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5AJ0
 | | Cryo electron microscopy of actively translating human polysomes (POST state). | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. | | Deposit date: | 2015-02-19 | | Release date: | 2015-05-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural Snapshots of Actively Translating Human Ribosomes
Cell(Cambridge,Mass.), 161, 2015
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6GZ5
 | | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | | Deposit date: | 2018-07-03 | | Release date: | 2018-12-05 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.
Cell Rep, 25, 2018
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8RQ2
 | | Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation III | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C. | | Deposit date: | 2024-01-17 | | Release date: | 2024-05-22 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
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