7BL4
 
 | | in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | Authors: | Hilal, T, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2021-01-18 | | Release date: | 2021-05-12 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.
Mol.Cell, 81, 2021
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7ZN7
 | | Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD | | Descriptor: | B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... | | Authors: | Lauer, S, Spahn, C.M.T, Schwefel, D. | | Deposit date: | 2022-04-20 | | Release date: | 2022-11-09 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
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7ZNN
 | | Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 | | Descriptor: | B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... | | Authors: | Lauer, S, Spahn, C.M.T, Schwefel, D. | | Deposit date: | 2022-04-21 | | Release date: | 2022-11-09 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
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8AZW
 | | Cryo-EM structure of the plant 60S subunit | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Smirnova, J, Loerke, J, Kleinau, G, Schmidt, A, Buerger, J, Meyer, E.H, Mielke, T, Scheerer, P, Bock, R, Spahn, C.M.T, Zoschke, R. | | Deposit date: | 2022-09-06 | | Release date: | 2023-06-07 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.14 Å) | | Cite: | Structure of the actively translating plant 80S ribosome at 2.2 angstrom resolution.
Nat.Plants, 9, 2023
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3RGW
 | | Crystal structure at 1.5 A resolution of an H2-reduced, O2-tolerant hydrogenase from Ralstonia eutropha unmasks a novel iron-sulfur cluster | | Descriptor: | FE3-S4 CLUSTER, FE4-S3 CLUSTER, IRON/SULFUR CLUSTER, ... | | Authors: | Scheerer, P, Fritsch, J, Frielingsdorf, S, Kroschinsky, S, Friedrich, B, Lenz, O, Spahn, C.M.T. | | Deposit date: | 2011-04-10 | | Release date: | 2011-10-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre.
Nature, 479, 2011
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5AJ0
 | | Cryo electron microscopy of actively translating human polysomes (POST state). | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. | | Deposit date: | 2015-02-19 | | Release date: | 2015-05-20 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural Snapshots of Actively Translating Human Ribosomes
Cell(Cambridge,Mass.), 161, 2015
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8RQ2
 | | Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation III | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C. | | Deposit date: | 2024-01-17 | | Release date: | 2024-05-22 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
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8RQ0
 | | Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation II | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C. | | Deposit date: | 2024-01-17 | | Release date: | 2024-05-22 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
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8RPY
 | | Escherichia coli 50S subunit in complex with the antimicrobial peptide Api137 | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 137, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C. | | Deposit date: | 2024-01-17 | | Release date: | 2024-05-22 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
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8RPZ
 | | Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation I | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, Apidaecins type 88, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C. | | Deposit date: | 2024-01-17 | | Release date: | 2024-05-22 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
Nat Commun, 15, 2024
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3J0P
 | | Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1 | | Descriptor: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10a, ... | | Authors: | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | | Deposit date: | 2011-10-06 | | Release date: | 2011-11-16 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (10.6 Å) | | Cite: | Structure and dynamics of the Mammalian ribosomal pretranslocation complex.
Mol.Cell, 44, 2011
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2ORW
 | | Thermotoga maritima thymidine kinase 1 like enzyme in complex with TP4A | | Descriptor: | MAGNESIUM ION, P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ... | | Authors: | Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A. | | Deposit date: | 2007-02-04 | | Release date: | 2007-03-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
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7N2V
 | | Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1) | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-29 | | Release date: | 2021-07-14 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N30
 | | Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-30 | | Release date: | 2021-07-14 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N2C
 | | Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-28 | | Release date: | 2021-07-14 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N1P
 | | Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, S.K, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-28 | | Release date: | 2021-07-14 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.33 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N31
 | | Elongating 70S ribosome complex in a post-translocation (POST) conformation | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-31 | | Release date: | 2021-07-14 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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7N2U
 | | Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | | Deposit date: | 2021-05-29 | | Release date: | 2021-07-14 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
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1AXM
 | | HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR | | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR | | Authors: | DiGabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A. | | Deposit date: | 1997-10-16 | | Release date: | 1998-04-22 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
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8AUV
 | | Cryo-EM structure of the plant 40S subunit | | Descriptor: | 18S rRNA, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Smirnova, J, Loerke, J, Kleinau, G, Schmidt, A, Buerger, J, Meyer, E.H, Mielke, T, Scheerer, P, Bock, R, Spahn, C.M.T, Zoschke, R. | | Deposit date: | 2022-08-25 | | Release date: | 2023-06-07 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | Structure of the actively translating plant 80S ribosome at 2.2 angstrom resolution.
Nat.Plants, 9, 2023
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1YSH
 | | Localization and dynamic behavior of ribosomal protein L30e | | Descriptor: | 40S RIBOSOMAL PROTEIN S13, RNA (101-MER), RNA (28-MER), ... | | Authors: | Halic, M, Becker, T, Frank, J, Spahn, C.M, Beckmann, R. | | Deposit date: | 2005-02-08 | | Release date: | 2005-07-05 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Localization and dynamic behavior of ribosomal protein L30e
Nat.Struct.Mol.Biol., 12, 2005
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1P62
 | | Structure of human dCK complexed with gemcitabine and ADP-MG | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, GEMCITABINE, ... | | Authors: | Sabini, E, Ort, S, Monnerjahn, C, Konrad, M, Lavie, A. | | Deposit date: | 2003-04-28 | | Release date: | 2003-07-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Nat.Struct.Biol., 10, 2003
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3J0L
 | | Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1 | | Descriptor: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10, ... | | Authors: | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | | Deposit date: | 2011-10-04 | | Release date: | 2011-11-16 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9.8 Å) | | Cite: | Structure and dynamics of the Mammalian ribosomal pretranslocation complex.
Mol.Cell, 44, 2011
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9H3Y
 | | 50S subunit precursor 50S_(L16)- | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, 5S ribosomal RNA, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-10-17 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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9HAL
 | | Pooled 50S subunit d126_(L29)-/(L22)- precursor states supplemented with Api137 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L3, Large ribosomal subunit protein bL17, ... | | Authors: | Lauer, S, Nikolay, R, Spahn, C.M.T. | | Deposit date: | 2024-11-04 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (4.49 Å) | | Cite: | The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.
Nat Commun, 16, 2025
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