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PDB: 136 件

1BAM
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STRUCTURE OF RESTRICTION ENDONUCLEASE BAMHI PHASED AT 1.95 ANGSTROMS RESOLUTION BY MAD ANALYSIS
分子名称: ENDONUCLEASE BamH I
著者Aggarwal, A.K, Newman, M.
登録日1994-12-28
公開日1995-02-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of restriction endonuclease bamhi phased at 1.95 A resolution by MAD analysis.
Structure, 2, 1994
7M7V
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BU of 7m7v by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with Compound 6
分子名称: 5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-[(2-oxa-6-azaspiro[3.4]octan-6-yl)methyl]-1-benzofuran-3-carboxamide, Polyketide synthase Pks13
著者Aggarwal, A, Sacchettini, J.C.
登録日2021-03-29
公開日2022-02-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J.Med.Chem., 65, 2022
2F03
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BU of 2f03 by Molmil
Crystal structure of tetrameric restriction endonuclease SfiI in complex with cognate DNA (partial bound form)
分子名称: CALCIUM ION, DNA (5'-D(*AP*AP*TP*AP*GP*GP*CP*CP*TP*TP*GP*TP*TP*GP*GP*CP*CP*AP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*G*TP*GP*GP*CP*CP*AP*AP*CP*AP*AP*GP*GP*CP*CP*TP*AP*TP*T)-3'), ...
著者Aggarwal, A.K, Vanamee, E.S, Viadiu, H
登録日2005-11-11
公開日2007-01-16
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA.
Embo J., 24, 2005
1BHM
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BU of 1bhm by Molmil
RESTRICTION ENDONUCLEASE BAMHI COMPLEX WITH DNA
分子名称: DNA (5'-D(*TP*AP*TP*GP*GP*AP*TP*CP*CP*AP*TP*A)-3'), PROTEIN (BAMHI (E.C.3.1.21.4))
著者Aggarwal, A.K, Newman, M.
登録日1995-07-12
公開日1995-07-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding.
Science, 269, 1995
2EZV
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BU of 2ezv by Molmil
Crystal structure of tetrameric restriction endonuclease SfiI bound to cognate DNA.
分子名称: 5'-D(*AP*GP*GP*CP*CP*TP*TP*GP*TP*TP*GP*GP*CP*CP*A)-3', 5'-D(*TP*GP*GP*CP*CP*AP*AP*CP*AP*AP*GP*GP*CP*CP*T)-3', CALCIUM ION, ...
著者Aggarwal, A.K, Vanamee, E.S, Viadiu, H.
登録日2005-11-10
公開日2006-01-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA
Embo J., 24, 2005
2R5Z
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BU of 2r5z by Molmil
Structure of Scr/Exd complex bound to a DNA sequence derived from the fkh gene
分子名称: DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DAP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DTP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ...
著者Aggarwal, A.K, Passner, J.M, Jain, R.
登録日2007-09-04
公開日2008-02-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Functional specificity of a Hox protein mediated by the recognition of minor groove structure
Cell(Cambridge,Mass.), 131, 2007
2R5Y
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Structure of Scr/Exd complex bound to a consensus Hox-Exd site
分子名称: DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DTP*DGP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DCP*DAP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ...
著者Aggarwal, A.K, Passner, J.M, Jain, R.
登録日2007-09-04
公開日2008-02-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Functional specificity of a Hox protein mediated by the recognition of minor groove structure
Cell(Cambridge,Mass.), 131, 2007
2OR1
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BU of 2or1 by Molmil
RECOGNITION OF A DNA OPERATOR BY THE REPRESSOR OF PHAGE 434. A VIEW AT HIGH RESOLUTION
分子名称: 434 REPRESSOR, DNA (5'-D(*AP*AP*GP*TP*AP*CP*AP*AP*AP*CP*TP*TP*TP*CP*TP*TP*G P*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*CP*AP*AP*GP*AP*AP*AP*GP*TP*TP*TP*GP*T P*AP*CP*T)-3')
著者Aggarwal, A.K, Rodgers, D.W, Drottar, M, Ptashne, M, Harrison, S.C.
登録日1989-09-05
公開日1989-09-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Recognition of a DNA operator by the repressor of phage 434: a view at high resolution.
Science, 242, 1988
5V3W
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Crystal Structure of the Apo form of Thioesterase domain of Mtb Pks13
分子名称: (2R)-2-{[(2R)-2-{[(2S)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propyl]oxy}propan-1-ol, Polyketide synthase Pks13 (Termination polyketide synthase)
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.723 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V40
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BU of 5v40 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM6
分子名称: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 4-[(dimethylamino)methyl]-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.991 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V3Z
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Crystal Structure of the D1607N mutant form of Thioesterase domain of Mtb Pks13
分子名称: PENTAETHYLENE GLYCOL, Polyketide synthase Pks13 (Termination polyketide synthase), SULFATE ION
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.881 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V42
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BU of 5v42 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM3
分子名称: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-2-phenyl-4-(pyrrolidin-1-ylmethyl)-1-benzofuran-3-carboxylate
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.987 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V3Y
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BU of 5v3y by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM16
分子名称: 2-(4-hydroxyphenyl)-~{N}-methyl-5-oxidanyl-4-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxamide, Polyketide synthase Pks13 (Termination polyketide synthase), SULFATE ION
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V41
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BU of 5v41 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM5
分子名称: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-4-(morpholin-4-ylmethyl)-2-phenyl-1-benzofuran-3-carboxylate
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V3X
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BU of 5v3x by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM1
分子名称: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-4-[(4-methylpiperidin-1-yl)methyl]-2-phenyl-1-benzofuran-3-carboxylate
著者Aggarwal, A, Sacchettini, J.C.
登録日2017-03-08
公開日2017-07-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.936 Å)
主引用文献Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
6UWA
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BU of 6uwa by Molmil
Mouse PKC C1B and C2 domains
分子名称: CITRIC ACID, LEAD (II) ION, Protein kinase C, ...
著者Aggarwal, A, Mire, J, Sacchettini, J.C, Igumenova, T.
登録日2019-11-04
公開日2020-12-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Mouse PKC C1B and C2 domains
To Be Published
3BJY
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BU of 3bjy by Molmil
Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DAP*DTP*DCP*DCP*DTP*DCP*DCP*DCP*DCP*DTP*DAP*(DOC))-3'), DNA (5'-D(*DTP*DAP*DAP*(P)P*DGP*DTP*DAP*DGP*DGP*DGP*DGP*DAP*DGP*DGP*DAP*DT)-3'), ...
著者Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2007-12-05
公開日2008-10-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase
Structure, 16, 2008
2ALZ
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BU of 2alz by Molmil
Ternary Complex of hPoli with DNA and dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*T)-3', ...
著者Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2005-08-08
公開日2005-10-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Human DNA Polymerase iota Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair.
Structure, 13, 2005
5J18
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BU of 5j18 by Molmil
Solution structure of Ras Binding Domain (RBD) of B-Raf complexed with Rigosertib (Complex I)
分子名称: N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine, Serine/threonine-protein kinase B-raf
著者Dutta, K, Vasquez-Del Carpio, R, Aggarwal, A.K, Reddy, E.P.
登録日2016-03-29
公開日2016-05-04
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell, 165, 2016
7S0T
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BU of 7s0t by Molmil
Structure of DNA polymerase zeta with mismatched DNA
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
著者Malik, R, Ubarretxena, I.B, Aggarwal, A.K.
登録日2021-08-31
公開日2022-03-09
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Cryo-EM structure of translesion DNA synthesis polymerase zeta with a base pair mismatch.
Nat Commun, 13, 2022
5IUD
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BU of 5iud by Molmil
Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer
分子名称: DNA polymerase alpha catalytic subunit, DNA primer, DNA template
著者Coloma, J, Aggarwal, A.K.
登録日2016-03-17
公開日2016-04-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Sci Rep, 6, 2016
3BAM
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BU of 3bam by Molmil
RESTRICTION ENDONUCLEASE BAMHI COMPLEX WITH DNA AND MANGANESE IONS (POST-REACTIVE COMPLEX)
分子名称: DNA (5'-D(*TP*AP*TP*G)-3'), DNA (5'-D(*TP*AP*TP*GP*GP*AP*TP*CP*CP*AP*TP*A)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*AP*TP*A)-3'), ...
著者Viadiu, H, Aggarwal, A.K.
登録日1998-08-19
公開日1999-01-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The role of metals in catalysis by the restriction endonuclease BamHI.
Nat.Struct.Biol., 5, 1998
5WM1
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BU of 5wm1 by Molmil
Structure of the 10S (+)-trans-BP-dG modified Rev1 ternary complex
分子名称: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ...
著者Rechkoblit, O, Kolbanovsky, A, Landes, H, Geacintov, N.E, Aggarwal, A.K.
登録日2017-07-28
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Nat Commun, 8, 2017
5WM8
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BU of 5wm8 by Molmil
Structure of the 10R (+)-cis-BP-dG modified Rev1 ternary complex
分子名称: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ...
著者Rechkoblit, O, Kolbanovsky, A, Landes, H, Geacintov, N.E, Aggarwal, A.K.
登録日2017-07-28
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Nat Commun, 8, 2017
9C3S
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BU of 9c3s by Molmil
Crystal structure of DNA N6-Adenine Methyltransferase M.BceJIV from Burkholderia cenocepacia in complex with duplex DNA substrate containing GTATAC as recognition sequence
分子名称: DNA1, DNA2, Methyltransferase, ...
著者Kottur, J, Quintana-Feliciano, R, Aggarwal, A.K.
登録日2024-06-02
公開日2024-09-11
最終更新日2024-09-18
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation.
Nat Commun, 15, 2024

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