2B5B
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![BU of 2b5b by Molmil](/molmil-images/mine/2b5b) | A reptilian defensin with anti-bacterial and anti-viral activity | 分子名称: | Defensin | 著者 | Chattopadhyay, S, Sinha, N.K, Banerjee, S, Roy, D, Chattopadhyay, D, Roy, S. | 登録日 | 2005-09-28 | 公開日 | 2006-06-27 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity. Proteins, 64, 2006
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1Z8Y
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![BU of 1z8y by Molmil](/molmil-images/mine/1z8y) | Mapping the E2 Glycoprotein of Alphaviruses | 分子名称: | Capsid protein C, Spike glycoprotein E1, Spike glycoprotein E2 | 著者 | Mukhopadhyay, S, Zhang, W, Gabler, S, Chipman, P.R, Strauss, E.G, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G. | 登録日 | 2005-03-31 | 公開日 | 2006-02-07 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses. Structure, 14, 2006
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8HMS
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![BU of 8hms by Molmil](/molmil-images/mine/8hms) | Crystal Structure of PKM2 mutant C474S | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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8HMQ
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![BU of 8hmq by Molmil](/molmil-images/mine/8hmq) | Crystal Structure of PKM2 mutant P403A | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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8HMR
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![BU of 8hmr by Molmil](/molmil-images/mine/8hmr) | Crystal Structure of PKM2 mutant L144P | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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8HMU
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![BU of 8hmu by Molmil](/molmil-images/mine/8hmu) | Crystal Structure of PKM2 mutant R516C | 分子名称: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, ... | 著者 | Upadhyay, S, Kumar, A, Patel, A.K. | 登録日 | 2022-12-05 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2 To Be Published
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4FRR
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![BU of 4frr by Molmil](/molmil-images/mine/4frr) | |
2IIR
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![BU of 2iir by Molmil](/molmil-images/mine/2iir) | |
2O97
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![BU of 2o97 by Molmil](/molmil-images/mine/2o97) | Crystal Structure of E. coli HU heterodimer | 分子名称: | CHLORIDE ION, DNA-binding protein HU-alpha, DNA-binding protein HU-beta, ... | 著者 | Guo, F, Adhya, S. | 登録日 | 2006-12-13 | 公開日 | 2007-03-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Spiral structure of Escherichia coli HU{alpha}beta provides foundation for DNA supercoiling. Proc.Natl.Acad.Sci.Usa, 104, 2007
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4YEX
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![BU of 4yex by Molmil](/molmil-images/mine/4yex) | HUaa-19bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YFT
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![BU of 4yft by Molmil](/molmil-images/mine/4yft) | HUab-20bp | 分子名称: | DNA-binding protein HU-alpha, DNA-binding protein HU-beta, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-25 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.914 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YEW
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![BU of 4yew by Molmil](/molmil-images/mine/4yew) | HUab-19bp | 分子名称: | DNA-binding protein HU-alpha, DNA-binding protein HU-beta, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.683 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YEY
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![BU of 4yey by Molmil](/molmil-images/mine/4yey) | HUaa-20bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.354 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YFH
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![BU of 4yfh by Molmil](/molmil-images/mine/4yfh) | HU38-20bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-25 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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4YF0
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![BU of 4yf0 by Molmil](/molmil-images/mine/4yf0) | HU38-19bp | 分子名称: | DNA-binding protein HU-alpha, synthetic DNA strand | 著者 | Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. | 登録日 | 2015-02-24 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
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5K47
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![BU of 5k47 by Molmil](/molmil-images/mine/5k47) | CryoEM structure of the human Polycystin-2/PKD2 TRP channel | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | 著者 | Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2016-05-20 | 公開日 | 2016-08-24 | 最終更新日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Nat. Struct. Mol. Biol., 24, 2017
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4TWK
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![BU of 4twk by Molmil](/molmil-images/mine/4twk) | Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Octyl Glucose Neopentyl Glycol, ... | 著者 | Pike, A.C.W, Dong, Y.Y, Tessitore, A, Goubin, S, Strain-Damerell, C, Mukhopadhyay, S, Kupinska, K, Wang, D, Chalk, R, Berridge, G, Grieben, M, Shrestha, L, Ang, J.H, Mackenzie, A, Quigley, A, Bushell, S.R, Shintre, C.A, Faust, B, Chu, A, Dong, L, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P. | 登録日 | 2014-06-30 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1) To Be Published
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2YPT
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![BU of 2ypt by Molmil](/molmil-images/mine/2ypt) | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A | 分子名称: | CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION | 著者 | Pike, A.C.W, Dong, Y.Y, Quigley, A, Dong, L, Savitsky, P, Cooper, C.D.O, Chaikuad, A, Goubin, S, Shrestha, L, Li, Q, Mukhopadhyay, S, Yang, J, Xia, X, Shintre, C.A, Barr, A.J, Berridge, G, Chalk, R, Bray, J.E, von Delft, F, Bullock, A, Bountra, C, Arrowsmith, C.H, Edwards, A, Burgess-Brown, N, Carpenter, E.P. | 登録日 | 2012-11-01 | 公開日 | 2012-12-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | The Structural Basis of Zmpste24-Dependent Laminopathies. Science, 339, 2013
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5LEV
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![BU of 5lev by Molmil](/molmil-images/mine/5lev) | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) | 分子名称: | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, UNKNOWN LIGAND | 著者 | Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-30 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell, 175, 2018
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8FGW
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![BU of 8fgw by Molmil](/molmil-images/mine/8fgw) | Human IFT-A complex structures provide molecular insights into ciliary transport | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ... | 著者 | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | 登録日 | 2022-12-12 | 公開日 | 2023-02-22 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Human IFT-A complex structures provide molecular insights into ciliary transport. Cell Res., 33, 2023
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8FH3
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![BU of 8fh3 by Molmil](/molmil-images/mine/8fh3) | Human IFT-A complex structures provide molecular insights into ciliary transport | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Tubby-related protein 3, ... | 著者 | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | 登録日 | 2022-12-13 | 公開日 | 2023-02-22 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Human IFT-A complex structures provide molecular insights into ciliary transport. Cell Res., 33, 2023
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8HY5
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![BU of 8hy5 by Molmil](/molmil-images/mine/8hy5) | Structure of D-amino acid oxidase mutant R38H | 分子名称: | 1,2-ETHANEDIOL, BENZOIC ACID, D-amino-acid oxidase, ... | 著者 | Khan, S, Upadhyay, S, Dave, U, Kumar, A, Gomes, J. | 登録日 | 2023-01-05 | 公開日 | 2023-01-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase. Int.J.Biol.Macromol., 256, 2023
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5LWN
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![BU of 5lwn by Molmil](/molmil-images/mine/5lwn) | Crystal structure of JAK3 in complex with Compound 5 (FM409) | 分子名称: | (2~{S})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},2~{R})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]propanamide, (~{Z})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},2~{R})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]prop-2-enamide, 1,2-ETHANEDIOL, ... | 著者 | Chaikuad, A, Forster, M, Mukhopadhyay, S, Kupinska, K, Ellis, K, Mahajan, P, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Laufer, S.A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-18 | 公開日 | 2016-10-26 | 最終更新日 | 2016-11-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol, 23, 2016
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6FM9
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![BU of 6fm9 by Molmil](/molmil-images/mine/6fm9) | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 著者 | Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2018-01-30 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell, 175, 2018
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5LWM
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![BU of 5lwm by Molmil](/molmil-images/mine/5lwm) | Crystal structure of JAK3 in complex with Compound 4 (FM381) | 分子名称: | 1,2-ETHANEDIOL, 1-phenylurea, 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{N},~{N}-dimethyl-prop-2-enamide, ... | 著者 | Chaikuad, A, Forster, M, Mukhopadhyay, S, Kupinska, K, Ellis, K, Mahajan, P, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Laufer, S.A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-18 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol, 23, 2016
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